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12. Stárnoucí muž z pohledu endokrinologa

Creator:
Stárka, Luboslav
Type:
model:article, article, Text, přehledy, and TEXT
Subject:
stárnutí, muži, androgeny--KREV--NEDOSTATEK, dehydroepiandrosteron--KREV--NEDOSTATEK, testosteron--KREV--NEDOSTATEK, příznaky a symptomy, hormonální substituční terapie, lidé, dospělí, lidé středního věku, staří, and mužské pohlaví
Language:
Czech and English
Description:
Je podán stručný souhrn nejdůležitějších endokrinních změn, které provázejí stárnutí u muže. Klíčovou je osa hypotalamus-hypofýza-testes, jejíž snížená výkonnost vede k relativnímu poklesu androgenů. Také snížený potenciál sekrece růstového hormonu je snížením androgenního zásobení ještě dále oslabován a podobně je tomu i u melatoninu. Specialni roli hraje nadledvinová kůra, která zásobuje organismus glukokortikoidy v podstatě ve stejné míře jako v období reprodukčního optima, ale nadledvinové androgeny, zejména dehydroepiandrosteron se svou pestrou škálou příznivých účinku na metabolismus, vykazují výrazný pokles s narůstajícím věkem. Suplementace chybějícími hormony je schopna v pozoruhodné míře zmírnit známky a symptomy endokrinosenescence., There is a brief summary of the most important endocrine changes going with man's ageing here. The essential is the hypotalamus - pituitary gland - testes axis, the decreased capacity of which leads to the relative androgens loss. The lowered potential of growth hormone secretion is also further impaired by lowered androgens supply and similar situation is with melatonine. Special role has adrenal cortex, which supplies the organism with glucocorticoids basically at the same extent as in the reproduction optimum period, but adrenal cortex androgens, especially dehydroepiandrosterone with its wide range of positive effects on the metabolism show significant decrease with ageing. The supplementation with missing hormones is able to moderate the signs and the symptoms of endocrinosenescence at noticeable extent., Luboslav Stárka, Lit: 30, and Souhrn: eng
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

13. The steroid spectrum during and after quitting smoking

Creator:
Jandikova, H., Michaela Dušková, Kateřina Šimůnková, Racz, B., Hill, M., Eva Králíková, Karel Vondra, and Luboslav Stárka
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, muži, odvykání kouření, predikce, testosteron, men, smoking cessation, prediction, testosterone, SHBG, 14, and 612
Language:
English
Description:
Addiction to tobacco results in an imbalance of endocrine homeostasis in both sexes. This can also have impacts on fertility problems. The male reproductive system is less susceptible than that of females, with a worsening spermiogram in smokers, the most cited effect in the literature. However, the literature is inconsistent as to the effects of smoking on steroid hormone levels in men, and there is very little data on the effects of quitting smoking in men. In this study we followed 76 men before quitting smoking, and then after 6, 12, and 24 weeks and 1 year of abstinence. We measured basic anthropomorphic data and steroid hormone levels along with steroid neuroactive metabolites using GC-MS. We demonstrate lower androgen levels in men who smoke, and these changes worsened after quitting smoking. There was a drop in SHBG already in the first week of non-smoking, and levels continued to remain low. Male smokers have lower androgen levels compared to non-smokers. The lower the initial level of androgen, the lower the likelihood of success in quitting smoking. Changes in steroid hormones proved to be a promising marker for the prediction of success in quitting smoking., H. Jandikova, M. Duskova, K. Simunkova, B. Racz, M. Hill, E. Kralikova, K. Vondra, L. Starka., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public