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2. The Libechov minipig as a large animal model for preclinical research in Huntington’s disease – thoughts and perspectives

Creator:
Schramke, S., Schubert, R., Frank, F., Wirsig, M., Fels, M., Kemper, N., Schuldenzucker, V., and Reilmann, R.
Format:
print, text, and regular print
Type:
model:article, article, Text, práce podpořená grantem, and TEXT
Subject:
zvířata, zvířata geneticky modifikovaná, prasata, prasata miniaturní, modely u zvířat, preklinické hodnocení léčiv, Huntingtonova nemoc, chov, bydlení zvířat, časové faktory, mozek--anatomie a histologie, velikost orgánu, experimenty na zvířatech, etika výzkumu, and sekvenční homologie
Language:
Czech and English
Description:
Large animal models to explore the safety and tolerability of novel therapeutic approaches for Huntington’s disease (HD) are in exploration to achieve higher translational reliability in future studies. Recently, a Libechov minipig has been established as one new transgenic (Tg) large animal model for HD. We here discuss the advantages and limitations in using this model in HD with regards to breeding, housing, handling, and with respect to homology to humans and ethical considerations. A group of TgHD and wild type (WT) female minipigs (n = 36) was used to gain first evidence about abovementioned aspects. It is concluded that Libechov minipigs may fulfill an important role to bridge the gap between rodents and non‑human primates in the translation to humans. and S. Schramke, R. Schubert, F. Frank, M. Wirsig, M. Fels, N. Kemper, V. Schuldenzucker, R. Reilmann
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public