Parkinson's disease (PD), which is the second most common
neurodegenerative disorder after Alzheimer's disease, is firstly
defined after James Parkinson's report. It carries motor
symptoms such as resting tremor, bradykinesia and rigidity of
skeletal muscle and freezing of gait. Furthermore, non-motor
symptoms such as cognitive and behavioral problems, besides
sensory impairments are seen in the patients. However, they
may also suffer from sleep disorders or autonomic dysfunction.
Although there are some medications in order to symptomatic
management, but unfortunately, scientist could not have found
exact approaches to cure this disease. Hence, producing a model
which can express the most pathophysiologic and behavioral
aspects of the disease is a desire. In this paper, we aimed to
describe the different models of Parkinson's disease in brief.