Příspěvek přináší shrnutí poznatků o raně středověkém pohřbívání v aglomeraci hradiště v Libici nad Cidlinou. Díky soustavnému, více než jedno století trvajícímu zájmu archeologie máme k dispozici poměrně ucelený obraz vývoje významného raně středověkého centra. Rozlišení tří hlavních chronologických horizontů umožňuje sledovat v kontextu pohřebišť i dynamiku vývoje celé lokality. Na základě srovnání jednotlivých pohřebišť se autor pokouší o vymezení sociotopografie celé aglomerace hradiště a zároveň poukazuje na limity tohoto poznání založeného pouze na archeologických pramenech. and This paper provides a summary of knowledge relating to Early Medieval burial within the agglomeration of the fortified enclosure at Libice nad Cidlinou. Thanks to consistent interest on the part of archaeology for more than a century, a relatively complete picture is now available of the development of this important Early Medieval centre. The discernment of three main chronological horizons makes it possible to trace the development dynamic of the entire site in the context of the cemeteries. On the basis of a comparison of the individual cemeteries the author attempts to define the sociotopography of the whole enclosure agglomeration, and at the same time show the limits of this understanding based purely on the archaeological material.
Kontinuální tvorba výpotků jakékoliv etiologie zásadním způsobem ovlivňuje kvalitu života nemocných. Akumulace tekutiny v pleurální dutině postupně komprimuje plicní parenchym. Prvním příznakem bývá progrese námahové dušnosti, později se přidává i klidová dušnost. S nárůstem výpotku dochází ke kompresi plicního parenchymu s rozvojem plicní atelektázy. Nemocný je ohrožen vznikem zánětového onemocnění plic v nevzdušném plicním parenchymu. U diagnózy maligního onemocnění je riziko zánětových komplikací výrazně vyšší vzhledem k předchozí chemoterapii či radioterapii, která zásadním způsobem snižuje imunitu. Opakovaná tvorba výpotku se výrazně podílí na rozvoji terminálního stavu nádorové kachexie. Efektivní metodou léčby je chemická pleurodéza, která se užívá u vybraného spektra nemocných. Principem je navození aseptické pleuritidy. Nejefektivnější cestou aplikace léčiva je videotorakoskopie. V souboru bylo 47 nemocných, 29 (61,7 %) mužů a 18 (38,3 %) žen, s cytologicky prokázaným recidivujícím maligním pleurálním výpotkem. Věkové rozmezí 42–80 let, Ø věk 65 let. Cílem práce bylo objektivizovat průběh celkových a lokálních zánětových změn po talkáži. Efekt léčby nebyl ovlivněn základním typem nádorového onemocnění. U obou skupin nebyly významně odlišné pooperační komplikace, což dokládá bezpečnost zvolené metody a podporuje správně zvolený algoritmus léčby., Continuous pleural effusion production of any aetiology can significantly affect the quality of patients life. Chronic effusion accumulation in the pleural cavity can lead to lung parenchyma compression. The first symptom of this entity is a progressive exertional dyspnea, which can later turn in dyspnea at rest. With the increase of the pleural effusion volume, pulmonary atelectasis can develop due to chronic parenchycha compression. The patient is at risk of inflamatory complications from the territory of non-ventilated parenchyma. Patients with a diagnosis of malignant disease have this risk considerably higher due to their previous chemotherapy or radiation, which substantially affect the immunity system. Repeated pleural effusion formation can significantly take part in the development of the terminal status of cancer cachexia. An effective method of palliative treatment is a chemical pleurodesis, which is used in selected patients. The principle is inducing aseptic inflammation. The most effective way of application is via videothoracoscopy. In a group of 47 patients, there were 29 (61.7 %) men and 18 (38.3 %) women with cytologically diagnosed recurrent malignant pleural. The age ranged between 42 and 80 with average age of 65 years. The aim was to assess the course of local and systemic inflammatory changes after talc application. The effect of treatment was not influenced by the type of malignancy . In both groups there was no significant difference in postoperative complications. This proves the safety of the selected procedure and also supports the correctness of the chosen algorithm of treatment., Petr Habal, Nedal Omran, Karolina Jankovičová, Kateřina Kondělková, Jan Krejsek, Jiří Manďák, and Literatura
Mikrosvět elementárních částic, atomů a procesů odehrávajících se mezi nimi je plný podivností. Částice může projít naráz dvěma různými štěrbinami, fotony mohou být navzájem provázané na obrovské vzdálenosti, kočka (alespoň ona pověstná Schrödingerova) může být zároveň živá i mrtvá... Může pozoruhodný kvantový svqt dovolit i stav, kdy by nějaká látka bya sočasně pevná a supratekutá? A mohou kvantové supratekuté systémy pomoci osvětlit jeden z posledních nevyřešených problémů klasické fyziky - turoblenci? Vědci, včetně českých, intenzivné hledají odpovědi. and Jana Olivová.
The objective of our study was to assess the influence of mechanical ventilation on healthy body organs. Fifteen piglets (aged 6 weeks, 19-27 kg) were anesthetized, instrumented, and divided into three groups: Group A - spontaneously breathing, group B - mechanically ventilated with tidal volume 6 ml/kg, and group C - ventilated with tidal volume 10 ml/kg for 12 hours. The parameters of lung, heart, liver and kidney functions neurohumoral regulation and systemic inflammatory reaction were recorded initially (time-1) and after 12 hours (time-12) of mechanical ventilation. At the onset of experiment (time-1) the levels of soluble adhesive molecules were higher (CAM; P<0.01), glomerular filtration index and free water clearance were lower (P<0.05) in both ventilated groups than in group A. Right ventricle myocardial performance index was higher (RIMP; P<0.05) in group C when compared with group A. Levels of CAM (P<0.05) and creatinine clearance (P<0.01) were higher, free water clearance was lower (P<0.05) in group C when compared to group B. At time-12 the RIMP (P<0.05) and levels of CAM were increased (P<0.01), creatinine clearance was decreased (P<0.05) in both ventilated groups compared to the same parameter at time-1. Ventilation index was higher (P<0.05), and hypoxemic index was lower (P<0.01) in group C when compared to group B. In conclusion, this study showed that mechanical ventilation induced changes compatible with early inflammatory response in healthy animals. Higher tidal volumes had detrimental effect on ventilatory parameters, reduced myocardial performance and potentiated adverse reaction of other organs., J. Kobr ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
The aim of this study is to evaluate the results of total hip arthroplasty in patients with Parkinson's disease during a period of five years, focusing on the assessment of the risks and benefits of surgery. During this period we performed total hip arthroplasty in 14 patients (15 hips) with Parkinson's disease. Patients were evaluated by subjective symptoms and objective findings, with a focus on the use of support while walking and walking distance, severity of Parkinson's disease before surgery and at the time of the last follow-up. During the postoperative period, the following parameters were assessed: length of ICU stay, mobilization, complications, the total duration of hospitalization and follow-up care after discharge. Of the 11 patients (12 hips) followed-up 1-5 years with an average of 3 years after operation 8 cases showed progression of neurological disability. 5 patients (6 hips) showed an increased dependence on the use of support when walking and reduced distance that the patient was able to walk. Subjectively, 10 hip joints were completely painless and 2 patients complained of only occasional mild pain in the operated hip. Complications that were encountered were urinary tract infection (5 patients), cognitive impairment (3 patients) and pressure ulcer (2 patients). We did not observe any infection or dislocation of the prosthesis. Three patients fell and fractured the femur and 3 patients in our cohort died during follow up. Implantation of total replacement is possible with judicious indication after careful evaluation of neurological finding in patients with minimal or mild functional impairment of the locomotor system. Prerequisite for a good result is precise surgical technique and optimal implant position with balanced tension of the muscles and other soft tissues around the hip. and PG. Mathew, P. Sponer, T. Kucera, M. Grinac, J. Knízek
The present study investigated cardiac function in hearts of mice with total deficiency of the β1-, β2- and β3-adrenoceptors (TKO) in comparison to wildtype mice (WT). We investigated cardiac morphology and echocardiographic function, measured protein expression of Ca2+-regulatory proteins, SERCA 2a activity, myofibrillar function, and performed running wheel tests. Heart weight and heart-to-body weight ratio were significantly smaller in TKO as compared to WT. This was accompanied by a decrease in the size of the cardiomyocytes in TKO. Heart rate and ejection fraction were significantly diminished in TKO as compared to WT. Protein expressions of SERCA 2a, ryanodine receptor and Na+/Ca2+-exchanger were similar in TKO and WT mice, but phospholamban protein expression was increased. PKAdependent phosphorylation of phospholamban at serine 16 was absent and CaMKII-dependent phosphorylation at threonine 17 was decreased in TKO. All alterations were paralleled by a decrease in SERCA 2a-activity. A similar maximal calciumdependent tension but an increased myofibrillar calciumsensitivity was measured in TKO as compared to WT. We did not observe relevant functional impairments of TKO in running wheel tests. In the absence of β-agonistic stimulation, SERCA 2a activity is mainly regulated by alterations of phospholamban expression and phosphorylation. The decreased SERCA 2a activity following β-adrenoceptor deficiency may be partly compensated by an increased myofibrillar calcium-sensitivity., S. Lee ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
It is clear that Levinas’s critique of the dominance within Western philosophy of the concept of totality in Totality and Infinity was intended as a response to totalitarian-ism, but the extent to which this determines the organization of the book and the way in which this takes place has been largely misconceived. This is because of the failure to take seriously the opening question of whether or not we are duped by morality. The ethical resistance of the face of the Other does not adequately address that question until morality is secured against the challenge issued by a philosophy that equates being with war and that takes place only through the account of the infinite time of fecundity. Fecundity concretized in the family is the site of resistance to the totalitarian tendencies of any state that seeks for the sake of its preservation to legislate procreation. Hence fecundity and Eros are “beyond the face.” This reading draws on the important role given to fecundity in Time and the Other as well as the texts newly available in the first three volumes of Levinas’s Oeuvres.
Tento příspěvek přibližuje, jak se měnily interpretace konceptu totalitarismu od dvacátých let minulého století v příslušném ideologickém kontextu. Autoři vidí v Havelkově úvaze pokus o sociologizující redefinici totalitárního konceptu a komentují ji spíše skepticky. Upozorňují na to, že pokud pomineme čistě ideologická tvrzení, dají se za totalitární v pravém slova smyslu označit pouze dvě období v českých dějinách: německý protektorát (1939–1945) a první roky komunistické nadvlády (1948–1953). Pokud jde o pozdější období československého komunismu (od Stalinovy smrti), autoři navrhují uplatňovat na ně koncept posttotalitarismu, jak jej formuloval Juan J. Linz. To by na jednu stranu umožnilo rozlišovat mezi záměry vládnoucího systému a společenskou realitou, a tím také například pomohlo lépe popsat proměnlivý význam ideologie a mobilizace mas. Na druhou stranu nabízí tento model odlišnou terminologii pro ranou, vrcholnou a pozdní („zmraženou“) etapu posttotalitarismu v období takzvané normalizace. and This article traces the changes in interpretations of the concept of totalitarianism in various ideological contexts since the concept emerged in the 1920s. The authors argue that if one discounts claims of a purely ideological nature, only two periods in twentieth-century Czech history were truly totalitarian: the ‘Protectorate’ (1939–45) and the first few years of Communist rule, that is, from 1948 to 1953. Concerning the post-Stalinist period, the authors suggest that the concept of post-totalitarianism proposed by Juan Linz should be applied. This would make it possible, on the one hand, to distinguish between the goals that the system claimed to be putting into practice, and the reality prevailing in society. It would thus describe, for example, the changing importance of ideology and mass mobilization; on the other hand, the model offers a differentiated terminology for the early, mature, and, ultimately, ‘frozen’ stages of post-totalitarianism during the period of ‘normalization’.