We assessed the effect of the previously uncovered gap junctio n protein alpha 8 (Gja8) mutation present in spontaneously hypertensive rat - dominant cataract (SHR - Dca ) strain on blood pressure, metabolic profile, and heart and renal transcriptomes. Adult, standard chow-fed male rats of SHR and SHR - Dca strains were used. We found a significant, consistent 10-15 mmHg decrease in both systolic and diastolic blood pressures in SHR - Dca compared with SHR (P<0.01 and P<0.05 , respectively; repeated measures analysis of variance (ANOVA)). With immunohistochemistry, we were able to localize Gja8 in heart, kidney, aorta, liver, and lungs, mostly in endothelium; with no differences in expression between strains. SHR - Dca rats showed decreased body weight, high-density lipoprotein cholesterol concentrations and basa l insulin sensitivity in muscle. There were 21 transc ripts common to the sets of 303 transcripts in kidney and 487 in heart showing >1.2-fold difference in expression between SHR and SHR - Dca. Tumor necrosis factor was the most significant upstream regulato r and glial cell-derived neurotrophic factor family ligand-receptor interactions was the common enriched and downregulated canonical pathway both in heart and kidney of SHR - Dca. The connexin 50 mutation L7Q lowers blood pressure in the SHR - Dca strain, decr eases high-density lipoprotein cholesterol, and leads to substantial transcriptome changes in heart and kidney., O. Šeda, F. Liška, M. Pravenec, Z. Vernerová, L. Kazdová, D. Křenová, V. Zídek, L. Šedová, M. Krupková, V. Křen., and Obsahuje bibliografii
It has been argued that consciousness is not possible without peripheral self-consciousness; i.e., without an implicit awareness of oneself as the subject of one’s mental state. My purpose is to undermine this view. I contend that a subject’s first-personal access to her conscious mental states and an awareness of them as hers, along with a particular approach to consciousness according to which a subject cannot be unconsciously conscious of things motivate the view that consciousness is not possible without self-consciousness. In order to undermine this view I argue that not all conscious states are accompanied by a sense of mineness. I also reject the reasons for endorsing an approach to consciousness according to which a subject cannot be unconsciously conscious of things. Then I critically examine Kriegel’s arguments for the dependence of consciousness on self-consciousness based on the first-personal access a subject has to her conscious mental states and discuss the difficulties involved., To bylo argumentoval, že vědomí není možné bez periferního self-vědomí; tj. bez implicitní informovanosti o sobě jako o předmětu duševního stavu. Mým cílem je podkopat tento názor. Tvrdím, že první osobní přístup subjektu k jejím vědomým duševním stavům a jejich povědomí o nich, spolu s konkrétním přístupem k vědomí, podle něhož subjekt nemůže být podvědomě vědomi věcí, motivuje názor, že vědomí není možné bez sebe. -vědomí. Abych podcenil tento názor, argumentuji, že ne všechny vědomé stavy jsou doprovázeny smyslem pro jemnost. Odmítám také důvody pro podporu přístupu k vědomí, podle něhož subjekt nemůže nevědomě uvědomovat věci. Pak kriticky zkoumám Krieglovy argumenty pro závislost vědomí na sebevědomí založeném na prvním osobním přístupu subjektu k jejím vědomým duševním stavům a projednávaným problémům., and Sinem Elkatip Hatipoğlu
This paper focuses on the consensual security rights over the objects of intellectual property in the Czech Republic. The paper is based on the national report presented for the purpose of XX. Congress of the International Academy of Comparative Law (Japan, Fukuoka, 22-28 July 2018). In the first part of the paper, the authors describe the system of the intellectual property protection and explain the basic principles of the core sstems of IP protection: copyrights, patents, trademarks and industrial designs. in the next part the authors define three most common methods of the security rights over the intangible assets: a pledge, transfer of a right as a security, and a prohibition of the alienation or the encumbrance of assets. The paper subsequently deals with the following issues: typical structure of the security transaction, mechanisms of evaluating the IP rights used as collateral, and requirements needed for the effectiveness of security rights. With this regard the authors distinguish between the effects of the security rights over non-registered rights such as copyright or unregistered designs, and security rights over registered trademarks, granted patents or registered industrial designs. Special attention is paid to the security rights over the business enterprise. The final part of the paper is aimed at the statistical analysis. The authors describe how frequent is the use of the consensual security rights in Czech legal practice and what are the usual costs related to the secured transactions over the intellectual property., Pavel Koukal, Helena Pullmannová., and Obsahuje bibliografické odkazy
The simultaneous problem of consensus and trajectory tracking of linear multi-agent systems is considered in this paper, where the dynamics of each agent is represented by a single-input single-output linear system. In order to solve this problem, a distributed control strategy is proposed in this work, where the trajectory and the formation of the agents are achieved asymptotically even in the presence of switching communication topologies and smooth formation changes, and ensuring the closed-loop stability of the multi-agent system. Moreover, the structure and dimension of the representation of the agent dynamics are not restricted to be the same, as usually assumed in the literature. A simulation example is provided in order to illustrate the main results.
Consensus clustering algorithms are used to improve properties of traditional clustering methods, especially their accuracy and robustness. In this article, we introduce our approach that is based on a refinement of the set of initial partitions and uses differential evolution algorithm in order to find the most valid solution. Properties of the algorithm are demonstrated on four benchmark datasets.
The paper presents an algorithm for the solution of the consensus problem of a {linear }multi-agent system composed of identical agents. The control of the agents is delayed, however, these delays are, in general, not equal in all agents. {The control algorithm design is based on the H∞-control, the results are formulated by means of linear matrix inequalities. The dimension of the resulting convex optimization problem is proportional to the dimension of one agent only but does not depend on the number of agents, hence this problem is computationally tractable. } It is shown that heterogeneity {of the delays in the control loop} can cause a steady error in the synchronization. Magnitude of this error is estimated. The results are illustrated by two examples.
In this paper, the consensus of heterogeneous multi-agent systems (MASs) with uncertain Deny-of-Service (DoS) attack strategies is studied. In our system, all agents are time synchronized and they communicate with each other with a constant sampling period normally. When the system is under attack, all agents use the hold-input mechanism to update the control protocol. By assuming that the attack duration is upper bounded and the occurrence of the attack follows a Markovian jumping process, the closed-loop system in presence of such a kind of random DoS attack is modeled as a Markovian jumping system, and the attack probabilities are allowed to be partially unknown and uncertain. By means of Lyapunov stability theory and Markovian jumping system approach, sufficient conditions are proposed such that the output consensus can be achieved, and the controller gains are determined by solving some matrix inequalities. Finally, a simulation study on the mobile stage vehicles is performed, showing the effectiveness of main results.
In this paper, we consider a multi-agent consensus problem with an active leader and variable interconnection topology. The dynamics of the active leader is given in a general form of linear system. The switching interconnection topology with communication delay among the agents is taken into consideration. A neighbor-based estimator is designed for each agent to obtain the unmeasurable state variables of the dynamic leader, and then a distributed feedback control law is developed to achieve consensus. The feedback parameters are obtained by solving a Riccati equation. By constructing a common Lyapunov function, some sufficient conditions are established to guarantee that each agent can track the active leader by assumption that interconnection topology is undirected and connected. We also point out that some results can be generalized to a class of directed interaction topologies. Moreover, the input-to-state stability (ISS) is obtained for multi-agent system with variable interconnection topology and communication delays in a disturbed environment.
This paper investigates the high-order consensus problem for the multi-agent systems with agent's dynamics described by high-order integrator, and adopts a general consensus algorithm composed of the states' coordination control. Under communication delay, consensus algorithm in usual asynchronously-coupled form just can make the agents achieve a stationary consensus, and sufficient consensus condition is obtained based on frequency-domain analysis. Besides, a predictor-based consensus algorithm is constructed via multiplying the delayed neighboring agents' states by a delay-related compensation part. In our proposed algorithm, a compensating delay is introduced to match the communication delay. Specially, the original high-order consensus is regained when the compensating delay equals to the communication delay, but cannot be achieved if the compensating delay is not equivalent to the communication delay. Moreover, sufficient consensus convergence conditions are also obtained for the agents under our predictor-based algorithm with different compensating delay. Numerical studies for multiple quadrotors illustrate the correctness of our results.
In this paper, a new guidance problem with the impact time constraint for cooperative attack of multiple missiles is investigated, which can be applied to salvo attack of anti-ship missiles. It can be used to guide multiple missiles to hit a stationary target simultaneously at a desirable impact time. The considered impact time control problem can be transformed into a range tracking problem. Then the range tracking problem can be viewed a consensus problem of multi-missile systems. As the application of the distributed consensus controller of multi-agent systems, three distributed protocols are given to solve the cooperative attack problem for the advantages such as reducing cost, improving system efficiency, increasing flexibility and reliability of distributed control. Simulation results demonstrate the performance and feasibility of the given protocols.