In this investigation, a new algorithm is developed for the updating of a neural network. It is concentrated in a fuzzy transition between the recursive least square and extended Kalman filter algorithms with the purpose to get a bounded gain such that a satisfactory modeling could be maintained. The advised algorithm has the advantage compared with the mentioned methods that it eludes the excessive increasing or decreasing of its gain. The gain of the recommended algorithm is uniformly stable and its convergence is found. The new algorithm is employed for the modeling of two synthetic examples.
There are many problems of groundwater flow in a disrupted rock massifs that should be modelled using numerical models. It can be done via "standard approaches'' such as increase of the permeability of the porous medium to account the fracture system (or double-porosity models), or discrete stochastic fracture network models. Both of these approaches appear to have their constraints and limitations, which make them unsuitable for the large-scale long-time hydrogeological calculations. In the article, a new approach to the modelling of groudwater flow in fractured porous medium, which combines the above-mentioned models, is described. This article presents the mathematical formulation and demonstration of numerical results obtained by this new approach. The approach considers three substantial types of objects within a structure of modelled massif important for the groudwater flow - small stochastic fractures, large deterministic fractures, and lines of intersection of the large fractures. The systems of stochastic fractures are represented by blocks of porous medium with suitably set hydraulic conductivity. The large fractures are represented as polygons placed in 3D space and their intersections are represented by lines. Thus flow in 3D porous medium, flow in 2D and 1D fracture systems, and communication among these three systems are modelled together.
Multimedia social networks (MSNs) provide great convenience to users, while privacy leaks issues are becoming prominent. The studies on relationship-based access control have been widely used in social networks. However, with the dynamic development of social networks and rapid growth of user information, the access control does not completely meet the current system's need. In this paper, an attribute-based access control model called ABAC{MSN is proposed for MSNs. This model comprehensively considers user attributes, environment attributes and resource attributes, not only including relationships among users. In this model, users can set multimedia usage control policies based on three categories of user-defined attributes. A formal theoretical model is established, which includes constraint rules, data ow rules, policy conflict resolution mechanism, and applied to CyVOD.net, a multimedia social-network-platform prototype systems. The deployment and application denote that this method effectively and exibly addresses use-case scenarios of multi-attribute-based media access control, and improves the access security of social media platforms and resources.
The aim of the present work was to study the effect of 3- mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid (CMTI), an efficient aldose reductase inhibitor, on sorbitol accumulation in selected organs of streptozotocin-induced diabetic rats in vivo . In addition, the effect of CMTI on aldose reductase back reaction and on sorbitol dehydrogenase was determined. The model of experimental diabetes in male Wistar rats induced by streptozotocin was used. Experimental diabetes was induced by triple intraperitoneal doses of streptozotocin on three consecutive days. In diabetic rats, significant elevation of sorbitol concentration in the sciatic nerve and eye lenses was recorded. CMTI administered intragastrically (50 mg/kg/day) for five consecutive days significantly inhibited sorbitol accumulation in the sciatic nerve, yet it was without effect in eye lenses of diabetic animals. For aldose reductase back reaction, the substrate affinity of glycerol to aldose reductase was one order lower than that of glyceraldehyde in forward reaction. In addition, the back reaction was much slower, characterized by Vmax value of about 30 times lower than that of the forward reaction. Inhibition of aldose reductase by CMTI was characterized by closely related IC50 values in submicromolar range for both forward and back reactions. No significant inhibition of the second enzyme of the polyol pathway, sorbitol dehydrogenase, by 100 μM CMTI was recorded (I=0.9±2.7 %, n=3). To conclude, the presented results showed the ability of CMTI to affect the polyol pathway in diabetic rats in vivo and represent thus a further step in a complex preclinical evaluation of CMTI as a potential agent for treatment of chronic diabetic complications., M. Soltesova Prnova, J. Ballekova, A. Gajdosikova, A. Gajdosik, M. Stefek., and Obsahuje bibliografii
This paper presents idea flow, development and construction of an anthropomorphic hand which is intended to be used mainly in prosthetics. Fundamental results of simulations and optimization of grasp are shown. The prototype has been manufactured and the principal functionality of finger mechanism (drive three axes by one string) has been tested. A new mechanical principle has been developed which is based again on an idea of using less actuators then joints with keeping adaptability and functionality of the mechanism. and Obsahuje seznam literatury
In this paper, we propose a client-server based framework that alleviates the dissemination of XSS worms from the OSN. The framework initially creates the views corresponding to retrieved request on the server-side. Such views indicate that which part of the generated web page on the server can be accessed by user depending on the generated Access Control List (ACL). Secondly, JavaScript attack vectors are retrieved from the HTTP response by referring the blacklist repository of attack vectors. Finally, injection of sanitization primitives will be done on the client-side in place of extracted JavaScript attack vectors. The framework will perform the sanitization on such attack vectors strictly in a context-aware manner. The experimental testing of our framework has performed on the two platforms of open source OSN-based web applications. The observed detection rate of JavaScript attack vectors was effective and acceptable as compared to other existing XSS defensive methodologies. The proposed framework has optimized the method of auto-context-aware sanitization in contrast to other existing approaches and hence incurs a low and acceptable performance overhead.
The optimal and reliable performance of doubly fed induction generator is essential for the efficient and optimal operation of wind energy conversion systems. This paper considers the nonlinear dynamic of a DFIG linked to a power grid and presents a new robust model predictive control technique of active and reactive power by the use of the linear matrix inequality in DFIG-based WECS. The control law is obtained through the LMI-based model predictive control that allows considering both economic and tracking factors by optimization of an objective function, constraints on control signal and states of system and effects of nonlinearities, generator parameter uncertainties and external disturbances. Robust stability in the face of bounded disturbances and generator uncertainty is shown using Lyapunov technique. Numerical simulations show that the proposed control method is able to meet the desired specification in active and reactive power control in the presence of varieties of wind speed and pitch angle.
The development of smartphones, specifically their cameras, and imaging technologies has enabled their use as sensors/measurement tools. Here we aimed to evaluate the applicability of a fast and noninvasive method for the estimation of total chlorophyll (Chl), Chl a, Chl b, and carotenoids (Car) content of soybean plants using a smartphone camera. Single leaf disc images were obtained using a smartphone camera. Subsequently, for the same leaf discs, a Chl meter was used to obtain the relative index of Chl and the photosynthetic pigments were then determined using a classic method. The RGB, HSB and CIELab color models were extracted from the smartphone images and correlated to Chl values obtained using a Chl meter and by a standard laboratory protocol. The smartphone camera was sensitive enough to capture successfully a broad range of Chl and Car contents seen in soybean leaves. Although there was a variation between color models, some of the proposed regressions (e.g., the S and b index from HSB and Lab color models and NRI [RGB model]) were very close to the Chl meter values. Based on our findings, smartphones can be used for rapid and accurate estimation of soybean and Car contents in soybean leaves., J. P. G. Rigon, S. Capuani, D. M. Fernandes, T. M. Guimarães., and Obsahuje bibliografii
Endothelin B (ETB) receptors present in abundance the central nervous system (CNS) have been shown to have significant implications in its development and neurogenesis. We have targeted ETB receptors stimulation using a highly specific agonist, IRL-1620, to treat CNS disorders. In a rat model of cerebral ischemia intravenous administration IRL-1620 significantly reduced infarct volume and improved neurological and motor functions compared to control. This improvement, in part, is due to an increase in neuroregeneration. We also investigated the role of IRL-1620 in animal models of Alzheimer’s disease (AD). IRL-1620 improved learning and memory, reduced oxidative stress and increased VEGF and NGF in Aβ treated rats. IRL-1620 also improved learning and memory in an aged APP/PS1 transgenic mouse model of AD. These promising findings prompted us to initiate human studies. Successful chemistry, manufacturing and control along with mice, rat and dog toxicological studies led to completion of a human Phase I study in healthy volunteers. We found that a dose of 0.6 μg/kg of IRL-1620 can be safely administered, three times every four hours, without any adverse effect. A Phase II clinical study with IRL-1620 has been initiated in patients with cerebral ischemia and mild to moderate AD., A. Gulati, M. G. Hornick, S. Briyal, M. S. Lavhale., and Seznam literatury
In passing remarks, some commentators have noted that for Nagel, physicalism is true. It has even been argued that Nagel seeks to find the best path to follow to achieve future physicalism. I advance these observations by adding that for Nagel, we should discuss the consciousness problem not in terms of physical and mental issues but in terms of our desire to include consciousness in an objective/scientific account, and we can achieve this only by revising our self-conception, i.e., folk psychology, to develop a more detached view of experience. Through the project of objective phenomenology, Nagel aims to achieve some sort of objective, detached, and scientific explanation of the subjective nature of experience. This project seeks to make the truth of physicalism intelligible and consciousness more amenable to scientific study, potentially raising an even broader concept than the one physicalism originally proposes.