Aged people are the most susceptible group to COVID-19 infection. Immunosenescence characterized by impairment of immune function with inflamm-aging contributes to pathophysiological alterations, among which endocrine and metabolic diseases are not exception. Diabetes, obesity along with impairment of disorders of thyroid functions are the most frequent ones, the common feature of which is failure of immune system including autoimmune processes. In the minireview we discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes. Mentioned is also beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues. Particular attention is devoted to the role of ACE2 protein in the light of its intimate link with renin-angiotensin regulating system.
Cats are important hosts for different zoonotic parasites that can be hazardous to human health. To date, few studies have attempted to identify the factors affecting parasitic infections in shelter animals. This study aims to analyse the presence of endoparasites in shelter cats in Tartu, Estonia, and identify factors affecting endoparasite prevalence and intensity. The risk factors considered were age, location (urban vs rural cats) and time spent in shelter. In total, 290 faecal samples were collected from cats at an animal shelter in 2015-2016 and investigated for endoparasites using the concentration flotation technique. In total, 138 shelter cats (47.6%) were infected with endoparasites and their overall prevalence was: Toxocara cati (36.6%), Cystoisospora spp. (12.4%), Taeniidae gen. sp. (4.1%), Toxoplasma gondii/Hammondia hammondi (3.4%), Eucoleus aerophilus (2.1%), Cryptosporidium spp. (2.1%), Ancylostoma sp. (0.7%) and Giardia sp. (0.7%). Coinfections occurred in 38 cats (13.1%) most frequently of T. cati and Cystoisospora spp. (4.5%), Cystoisospora spp. and T. gondii/H. hammondi (2.1%). Where species identification of cestode and nematode samples was not possible according to morphology, genetic analysis of the mitochondrial cox1 gene was carried out. DNA was successfully analysed for 6 out of 13 samples that required genetic identification, revealing Ancylostoma tubaeforme in one nematode sample and Hydatigera taeniaeformis in five cestode samples. Cats from rural areas had significantly higher endoparasite prevalence than cats from urban areas. Helminth prevalence decreased to some extent due to anthelmintic treatment in cats available for adoption (held ≥15 days in the shelter), whereas the prevalence of infection with protists increased significantly in these animals. It is important to note that the analysis revealed lower infection intensity for quarantine cats (held 1-14 days in the shelter) compared with cats available for adoption. The relatively high prevalence of endoparasites (including zoonotic) in shelter cats ready for adoption suggests that current anthelminthic procedures require improvements.
Heart remodeling occurs as a compensation mechanism for the massive loss of tissue during initial heart failure and the consequent inflammation process. During heart remodeling fibroblasts differentiate to myofibroblasts activate their secretion functions and produce elevated amounts, of extracellular matrix (ECM) proteins, mostly collagen, that form scar tissue and alter the normal degradation of ECM. Scar formation does replace the damaged tissue structurally; however, it impedes the normal contractive function of cardiomyocytes (CMs) and results in longlasting effects after heart failure. Besides CMs and cardiac fibroblasts, endothelial cells (ECs) and circulating endothelial progenitor cells (cEPCs) contribute to heart repair. This review summarizes the current knowledge of EC-CM crosstalk in cardiac fibrosis (CF), the role of cEPCs in heart regeneration and the contribution of Endothelial-mesenchymal transition (EndoMT)., Barbara Šalingová, Zdenko Červenák, Andriana Adamičková, Nikola Chromanicová, Simona Valášková, Andrea Gažová, Ján Kyselovič., and Obsahuje bibliografii
The purpose of the work is to establish the correlation between the change of absolute rotation poles of major tectonic plates based on continuous GNSS stations data. The work investigates 2804 continuous GNSS stations located on Pacific, North American, Eurasian, African, Antarctic, Australian and South American plates during 2002-2021. The components of recent horizontal displacements of continuous GNSS stations have been determined and a map of their distribution pattern has been constructed. The absolute rotation pole in ITRF2014/IGS14 reference frame of the studied tectonic plates has been determined. The obtained values are in good agreement with modern plate models. The definition of average annual rotation poles has been developed and their analysis has been carried out to research the dynamics of their change in time. It has been established that the change in the average annual rotation poles of the North American, African and South American plates occurs synchronously, while their change is asynchronous to the Pacific plate. Simultaneous changes in the average annual rotation poles of Antarctic and African plates were have also been identified.
Beerkan infiltration runs could provide an incomplete description of infiltration with reference to either the near steady-state or the transient stages. In particular, the process could still be in the transient stage at the end of the run or some transient infiltration data might be loss. The Wu1 method and the BEST-steady algorithm can be applied to derive soil hydrodynamic parameters even under these circumstances. Therefore, a soil dataset could be developed using two different data analysis methods. The hypothesis that the Wu1 method and BEST-steady yield similar predictions of the soil parameters when they are applied to the same infiltration curve was tested in this investigation. For a sandy-loam soil, BEST-steady yielded higher saturated soil hydraulic conductivity, Ks, microscopic pore radius, λm, and depth of the wetting front at the end of the run, dwf, and lower macroscopic capillary length, λc, as compared with the Wu1 method. Two corresponding means differed by 1.2–1.4 times, depending on the variable, and the differences appeared overall from moderate to relatively appreciable, that is neither too high nor negligible in any circumstance, according to some literature suggestions. Two estimates of Ks were similar (difference by < 25%) when the gravity-driven vertical flow and the lateral capillary components represented the 71–89% of total infiltration. In conclusion, the two methods of data analysis do not generally yield the same predictions of soil hydrodynamic parameters when they are applied to the same infiltration curve. However, it seems possible to establish what are the conditions making the two methods similar.
Regarding the fact that gay men leave less offspring than straight men, it is appropriate to raise a question by which means is male homosexuality maintained in a population and what could eventually be its evolutionary role. The aim of this paper is to summarize theories that try to explain male homosexuality within the framework of evolution. Furthermore, it aims to critically evaluate the results of empirical research that support particular theories or give evidence against them. In the first part, the paper provides a review of knowledge about the genetic and immunological origins of male homosexuality which consequently serves as a theoretical base for the main part of the paper that pursues the five most influential evolutionary theories of male homosexuality. and Homosexuální orientace se vyznačuje trvalou citovou a sexuální náklonností k jedincům stej-ného pohlaví. Vzhledem k tomu, že homosexu-álně orientovaní muži zanechávají méně potom-stva než heterosexuálně orientovaní muži, je na místě si položit otázku, jakými mechanismy je mužská homosexualita v populaci udržována a jaký by případně mohl být její evoluční vý-znam – tedy zda a případně komu (když ne ho-mosexuálnímu jedinci) přináší výhodu ve smy-slu vyššího reprodukčního úspěchu. Cílem této přehledové studie je shrnout teorie, jež se snaží mužskou homosexualitu vysvětlit v evolučním rámci, a kriticky zhodnotit výsledky empiric-kých výzkumů, které podporují jednotlivé teo-rie, či svědčí proti nim. Úvodní část článku po-skytuje přehled poznatků o genetickém a imu-nologickém původu homosexuality u mužů, rovněž však slouží jako teoretický základ pro hlavní část, která se věnuje pěti nejvlivnějším evolučním teoriím mužské homosexuality.
Hlavním cílem článku Hedonismus a eutanazie je ilustrovat komplexní vztahy mezi hédonismem jako teorií welfare a problémem racionality sebeusmrcení, asistovaného sebeusmrcení a eutanazie. Článek je rozdělený na tři části. První část přináší stručný popis hédonismu a vrcholí definicí standardního hédonismu. Druhá část se věnuje problému, zda smrt může v některých (výjimečných) situacích představovat racionálně ospravedlnitelnou volbu. Třetí a konečná část spojuje konsekvencialismus s tradičním hédonismem do standardního utilitarismu a předkládá přímý argument ve prospěch závěru, že asistovaná smrt může být eticky přijatelnou (dokonce povinnou) volbou. Ukazuje však, že hédonismus není adekvátní teorií dobrého života, a proto nakonec etický argument ve prospěch asistované smrti odmítá., The overall aim of the article “Hedonism and Euthanasia” is to illustrate the complex interplay between hedonism as a theory of welfare and the problem of the rationality of suicide, assisted suicide and euthanasia. The article is divided into three parts. In the first part, it provides a succinct description of hedonism culminating in the definition of standard hedonism. The second part deals with the problem of whether death can in some (exceptional) circumstances represent a rationally justifiable choice. The third and final part combines consequentialism with standard hedonism, obtaining standard utilitarianism, and sets forth a straightforward argument for the conclusion that assisted death might be an ethically acceptable (even obligatory) choice. However, hedonism is shown to be an inadequate theory of good life and, consequently, the ethical argument for assisted death is rejected., and David Černý.
An information-theoretic approach was used to evaluate non-native freshwater fish species introduced to insular habitats of Hawaii and Guam comparing successful establishments vs. failures. Since the late 1800s, as many as 81 non-native freshwater fish species have been recorded as introduced to Hawaii and Guam (combined) and 50 (62%) of these are documented as having one or more established populations. We examined eleven independent variables to investigate establishment success by creating 21 a priori logistic regression models ranked using Akaike's Information Criterion adjusted for small sample size. An additional eight post-hoc models were included that comprised the best a priori model and various combinations of individual variables. The best overall model of establishment probability included effects of taxonomic affinity (family membership), prior establishment success on other tropical islands, and hypoxia tolerance. Establishment success in Hawaii and Guam was highest for those species established on many other islands, and according to our best model air-breathing fishes were more likely to become established. Six fish families, each with from three to 18 species introduced to Pacific islands, were highly successful at establishment: Cichlidae (16 established of 18 species introduced), Poeciliidae (seven of eight), Cyprinidae (four of seven), Centrarchidae (four of four), Clariidae (three of three), and Loricariidae (three of four). Those that successfully established include both small and moderately large-bodied taxa, while representing a diverse array of other morphological and life-history traits. Pathways and motives associated with fish introductions in the Pacific have been linked to desires to develop aquaculture, enhance wild stocks of food, sport, and bait fishes, for use as biological control agents, or are linked to the ornamental fish trade. We found that many established species were introduced via multiple pathways (up to eight) and our analyses suggest that the combination of prior establishment success on other tropical islands and presence of non-native fishes in multiple pathways was indicative of high propagule pressure. Our study results and conclusions on Pacific tropical island introductions are in general agreement with previous studies on non-native freshwater fishes in other regions of the world and similar to observations in continental ecosystems and temperate zones.
Many soils and other porous media exhibit dual- or multi-porosity type features. In a previous study (Seki et al., 2022) we presented multimodal water retention and closed-form hydraulic conductivity equations for such media. The objective of this study is to show that the proposed equations are practically useful. Specifically, dual-BC (Brooks and Corey)-CH (common head) (DBC), dual-VG (van Genuchten)-CH (DVC), and KO (Kosugi)1BC2-CH (KBC) models were evaluated for a broad range of soil types. The three models showed good agreement with measured water retention and hydraulic conductivity data over a wide range of pressure heads. Results were obtained by first optimizing water retention parameters and then optimizing the saturated hydraulic conductivity (Ks) and two parameters (p, q) or (p, r) in the general hydraulic conductivity equation. Although conventionally the tortuosity factor p is optimized and (q, r) fixed, sensitivity analyses showed that optimization of two parameters (p + r, qr) is required for the multimodal models. For 20 soils from the UNSODA database, the average R2 for log (hydraulic conductivity) was highest (0.985) for the KBC model with r = 1 and optimization of (Ks, p, q). This result was almost equivalent (0.973) to the DVC model with q = 1 and optimization of (Ks, p, r); both were higher than R2 for the widely used Peters model (0.956) when optimizing (Ks, p, a, ω). The proposed equations are useful for practical applications while mathematically being simple and consistent.