The notion of a bilattice was introduced by Shulman. A bilattice is a subspace analogue for a lattice. In this work the definition of hyperreflexivity for bilattices is given and studied. We give some general results concerning this notion. To a given lattice L we can construct the bilattice \sum {_L}. Similarly, having a bilattice Σ we may consider the lattice \mathcal{L}_\Sigma . In this paper we study the relationship between hyperreflexivity of subspace lattices and of their associated bilattices. Some examples of hyperreflexive or not hyperreflexive bilattices are given., Kamila Kliś-Garlicka., and Obsahuje seznam literatury
Hyperhomocysteinemia has been suggested to induce hypertension due to its role in endothelial dysfunction. However, it remains controversial whether homocysteine and hypertension are truly causally related or merely loosely associated. To test the hypothesis that hyperhomocysteinemia occurs in spontaneously hypertensive rats (SHR) we measured plasma levels of homocysteine in 10 male adult SHR and in 10 normotensive controls using ion exchange chromatography. In addition, plasma concentrations of the 22 most common amino acids were measured to explore the relation of homocysteine with amino acid metabolism. Plasma levels of homocysteine were significantly lower in SHR (4.1±0.1 μmol/l) than in controls (7.2±0.3 μmol/l) (p<0.00001). The amounts of aminobutyric acid, alanine, citrulline and valine were also decreased, whereas we found increased levels of aspartate, glutamate, glutamine, histidine and ornithine. Thus, contrary to our hypothesis, hypertension in SHR occurs despite low plasma levels of homocysteine. We provide a new hypothesis whereby reduced conversion of arginine to citrulline is related to increased ornithine levels, but decreased bioavailability of nitric oxide, resulting in impaired blood vessel relaxation and hypertension. In conclusion, our findings do not necessarily exclude that homocysteine and hypertension might be pathophysiologically connected, but corroborate the notion that hypertension can arise due to mechanisms independent of high homocysteine levels., D. Kondziella, H. Zetterberg, E. Haugen, M. Fu., and Obsahuje bibliografii a bibliografické odkazy
With the increasing prevalence of obesity and especially abdominal obesity, a simple clinical tool is needed that identifies the cardiometabolic risk for cardiovascular disease and type 2 diabetes. The aim of our study was to evaluate a broad spectrum of metabolic variables and IMT in subjects with and without hypertriglyceridemic waist (HTGW) and compare it with the harmonized definition of metabolic syndrome (MS) with both a higher (MS- I) and lower waist circumference (MS -II) for Europids. We enrolled 607 asymptomatic dyslipidemic subjects (295 men and 312 women) into our cross -sectional study. The subjects with HTGW had an atherogenic lipid profile (significantly higher triglycerides, AIP, non -HDL -C, lower HDL -C and ApoA -1, and the women also higher TC and ApoB), increased markers of insulin resistance (insulin, HOMA, C -peptide, proinsulin), inflammation (hsCRP), thrombosis (fibrinogen, PAI -1), SBP and DBP, and lower adiponectin (p<0.05 -0.001 for all). These risk factors were entirely similar in HTGW, MS- I and MS -II. Age -adjusted IMT was significantly higher only in the women with HTGW but this significance disappeared after further adjustment for TC, SBP, and smoking. Our results support the routine use of HTGW as a simple and inexpensive screening tool to detect subjects at increased cardiometabolic risk in clinical practice., H. Vaverková, D. Karásek, D. Novotný, M. Halenka, J. Orság, L. Slavík., and Obsahuje bibliografii
The appearance of variations in the protein profile of Ostertagia ostertagi (Stiles, 1892) infective larvae (L3), which were induced by hypobiosis triggering factors, was evaluated by means of SDS-PAGE and densitometric analysts. Area integration analyses of their protein profiles was carried out between 66 and 77 kDa. Important quantitative variations were identified in the protein levels of the induced larvae, where a 5.25 fold increase compared to the control was observed. Two 75.4 and 70 kDa protein bands were found which exceeded the control profile by 4.5 and 44 fold, respectively. This fact suggests that the changes brought about in the process of hypobiosis induction are restricted. This work demonstrates changes at a molecular level corresponding with biological changes induced by conditions causing O. ostertagi hypobiosis.
Hypoechinorhynchus robustus sp. n. is described from Notolabrus parilus (Richardson) (Labridae) from Pt Peron, Western Australia. It has a proboscis with 30 hooks arranged in ten longitudinal rows: 5 rows of a small apical spine, a large anterior hook and a small posterior spine, 5 rows of a large anterior hook, a middle spine and a posterior spine. The new species is distinguished from other species of the genus by having a set of 5 small apical spines anterior to the large hooks on the proboscis, by having lemnisci that barely exlend beyond the proboscis receptacle and testes which are more adjacent than tandem. II. robustus also has robust trunk spines anteriorly. Re-examination of Hypoechinorhynchus alaeopis Yamaguti, 1939 (type species) revealed trunk spines that had been overlooked previously. The Hypoechinorhynchidae is made a junior synonym of Arhythmacanthidae because there is considerable overlap between the two family diagnoses, particularly in that both families have a proboscis armature that changes abruptly from small basal spines to large apical (or subapical if present) hooks. The genus Hypoechinorhynchus is placed in the subfamily Arhythmacanthinae because it has trunk spines and a spherical proboscis with few hooks (relative to other arhythmacanthid genera). It is also proposed that Ileterosentis magellanicus (Szidat, 1950) be returned to the genus Hypoechinorhynchus since it was transferred to Heterosentis primarily because it had trunk spines. The other hypoechinorhynchid genus contained only Bolborhynchoides exiguus (Achmerov el Dombrowskaja-Achmcrova, 1941) Achmerov, 1959 and is relegated to incertae sedis.
This paper presents and discusses the results of an experiment testing the validity of the Trace Deletion Hypothesis (Grodzinsky 1989, 2000) in Czech. The Trace Deletion Hypothesis (= TDH) was proposed to account for a receptive syntactic deficit in Broca’s aphasics that involves structures containing transformational operations such as the passive. According to the assumptions of the TDH, in passive constructions Broca’s aphasics fail to assign a semantic θ-role to the derived subject syntactically, so they assign it the Agent θ-role by linear consideration (Default Principle), which results in a structure with two potential Agents. This strategy is supposed to lead to the chance performance of Broca’s aphasics in these structures, as they are forced to guess the distribution of the Agent and the Patient θ-roles. The results of our experiment, however, do not support the TDH-proposal: out of the six tested subjects, only one performed at chance. The error rate for reversible passive structures in Czech was 33.34%, which corresponds to an above-chance performance. Given these results, the validity of the TDH is called into question, also with respect to the development of the generative theory itself., In diesem Artikel werden Ergebnisse eines Experiments präsentiert und diskutiert, in dem die Validität der sogenannten Spurentilgungshypothese (Trace Deletion Hypothesis – Grodzinsky, 1989, 2000) für das Tschechische überprüft wurde. Die Spurentilgungshypothese (= STH) wurde vorgeschlagen, um rezeptive syntaktische Defizite von Strukturen mit Transformationsoperationen (z. B. das Passiv) zu erklären, die bei Patienten mit Broca-Aphasie auftauchen. Beim Verständnis von Passivkonstruktionen misslingt den Broca-Aphasikern laut der STH die Zuordnung der semantischen θ-Rolle zum syntaktisch derivierten Subjekt. Stattdessen stützen sich die Broca-Aphasiker bei der Zuweisung der Agens θ-Rolle auf die lineare Abfolge der Satzglieder (Default Prinzip), was dazu führt, dass die Struktur aus Sicht der Aphasiker zwei potentielle Agens hat. Diese Strategie führt zu einer zufälligen Wahl, da Broca-Aphasiker die Verteilung zwischen den Agens und Patiens θ-Rollen raten müssen. Die Ergebnisse des hier vorgestellten Experiments unterstützen die Gültigkeit der STH-Hypothese nicht: Von sechs getesteten Probanden wies nur ein Proband eine zufällige Verteilung der semantischen Rollen auf. Die Fehlerrate für reversible Passivkonstruktionen im Tschechischen lag bei 33,34 % – dies entspricht einer überzufälligen Leistung der Probanden bezüglich der Zuordnung der semantischen θ-Rollen. Angesichts dieser Resultate muss die Validität der STH-Hypothese in Frage gestellt werden, und zwar auch im Hinblick auf die allgemeine Entwicklung der generativen Theorie., Andrea Hudousková, Eva Flanderková, Barbara Mertins, Kristýna Tomšů., and Obsahuje seznam literatury
a1_Vascular repair in response to injury or stress (often referred to as remodeling) is a common complication of many cardiovascular abnormalities including pulmonary hypertension, systemic hypertension, atherosclerosis, vein graft remodeling and restenosis following balloon dilatation of the coronary artery. It is not surprising that repair and remodeling occurs frequently in the vasculature in that exposure of blood vessels to either excessive hemodynamic stress (e.g. hypertension), noxious blood borne agents (e.g. atherogenic lipids), locally released cytokines, or unusual environmental conditions (e.g. hypoxia), requires readily available mechanisms to counteract these adverse stimuli and to preserve structure and function of the vessel wall. The responses, which were presumably evolutionarily developed to repair an injured tissue, often escape self-limiting control and can result, in the case of blood vessels, in lumen narrowing and obstruction to blood flow. Each cell type (i. e. endothelial cells, smooth muscle cells, and fibroblasts) in the vascular wall plays a specific role in the response to injury. However, while the roles of the endothelial cells and smooth muscle cells (SMC) in vascular remodeling have been extensively studied, relatively little attention has been given to the adventitial fibroblasts. Perhaps this is because the fibroblast is a relatively ill-defined cell which, at least compared to the SMC, exhibits few specific cellular markers. Importantly though, it has been well demonstrated that fibroblasts possess the capacity to express several functions such as migration, rapid proliferation, synthesis of connective tissue components, contraction and cytokine production in response to activation or stimulation., a2_The myriad of responses exhibited by the fibroblasts, especially in response to stimulation, suggest that these cells could play a pivotal role in the repair of injury. This fact has been well documented in the setting of wound healing where a hypoxic environment has been demonstrated to be critical in the cellular responses. As such it is not surprising that fibroblasts may play an important role in the vascular response to hypoxia and/or injury. This paper is intended to provide a brief review of the changes that occur in the adventitial fibroblasts in response to vascular stress (especially hypoxia) and the role the activated fibroblasts might play in hypoxia-mediated pulmonary vascular disease., K. R. Stenmark, D. Bouchey, R. Nemonoff, E. C. Dempsey, M. Das., and Obsahuje bibliografii
Phosphoenolpyruvate carboxylase isolated from Panicům maximum Jacq. leaf presented a hysteretic behaviour that resulted in a kinetical lag in the reaction progress curve. This lag depended on the concentration of etuiyme, total phosphoenolpyruvate (PEP) and total Mg2+. Through an analysis of these dependences it is suggested that the hysteresis is due to an association-dissociation process influenced by union, to one form of the enzyme, of more than one of the three possible ligands; free Mg2+, free PEP or PEP-Mg2+ complex. The partially purified enzyme showed, during steady statě, a Michaelis-Menten kinetics for PEP and Mg2+ (total concentrations) and pH optima between 7.8 and 8.2.