Induced pluripotent stem cells (iPSC) are undifferentiated cells capable of unlimited self-renewal. By introducing specific transcription factors, any somatic (fully differentiated) cell of the mammalian body can be changed (reprogrammed) into iPSC. The iPSCs are very similar to embryonic stem cells in their molecular and functional properties. By using specific factors, iPSCs can be differentiated into each of the about 200 cell types in the human body. The big advantage of iPSCs is the availability of somatic cells (isolation from blood or skin biopsy). Creation of "tailor made" iPSCs for each patient would allow transplantation of own cells and avoid problems with finding an immunologically compatible donor. and Kateřina Vodičková Kepková, Petr Vodička, Jan Motlík.
Pro hloubavého čtenáře jsou v hlavní části článku shromážděna v historické posloupnosti fakta k zamyšlení se nad výše položenou otázku. V roce 2016 uplyne 170 roků od jednoho z nejvýznamněších činů lidského intelektu v historii nebeské mechaniky - objevu planety Neptun. Udál se za neobvyklých a částečně i dramatických okolností na různých mistech Evropy. Proběhl zásluhou úspěšného propojení matematicky obtížných a časově náročných výpočtů ve Francii, Anglii a krátkého pozorování v Německu., The discovery of planet Neptune is one of the greatest events in the history of celestian mechanics. Le Verrier and simultaneously Adam applied inverse perturbation theory to the problem of Uranus, whose irregularities in motion could be used for determination of the orbit and mass of a yet unknown planet. These very complicated computations were successfully finished in summer 1846. Neptune was discovered by Johann Galle using le Verrier‘s predictions in September of the same year proving that the mathematical methods and numerical calculations were not fundamentally flawed. Therefore, dicovery of Neptune cannot be considered as accidental., and Vladimír Štefl.
The recently announced results from the ICEP2 experiment are intepreted as an indirect observation of inflation gravitational waves. In this article we briefly discuss the cosmic inflation hypothesis, what is the B-mode, how it was measured, and why the polarization of the cosmic microwave background radiation can reveal how strong gravitational waves were present in the universe during this early epoch., Tomáš Ledvinka., and Obsahuje seznam literatury
In the existential sentences of Slavonic languages we can find some interesting deviations from the basic type of Indo-European sentences, ie. "Nominative + concordant Verb", for instance Genitive of negation; in some, especially South Slavonic languages there are examples of the main nominal part of positive existential sentence (ie. name of the existing entity) in Genitive or even (as in Slovenian povsod jo je) in Accusative. These deviations can be of interest for the study of the development of Indo-European syntax, as Miklosich and Potebnya already in the 19th century observed. Relevant in this aspect also is the opposition between autosemantic (existential or possessive) esse and (zero or non zero) copula. This phenomena are here studied from the standpoint of the general opposition between polymorphic and monomorphic structures of the syntactical system.