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2. Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: implications for the treatment of posttraumatic stress disorder
- Creator:
- Wang, H.-N., Peng, Y., Tan, Q.-R., Chen, Y.-C., Zhang, R.-G., Qiao, Y.-T., Wang, H.-H., Liu, L., Kuang, F., Wang, B.-R., and Zhang, Z.-J.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, úzkost, anxiety, PTSD, quetiapine, cognitive impairment, ERK, 14, and 612
- Language:
- English
- Description:
- The purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy., H.-N. Wang ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
3. Rizikové faktory pre vznik posttraumatickej stresovej poruchy po pôrode: prehľadový článok
- Creator:
- Kotríková Rašmanová, Miroslava, Kaščáková, Natália, Hašto, Jozef, and Tavel, Peter
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- posttraumatic stress disorder, PTSD, childbirth, trauma, risk factors, posttraumatická stresová porucha, PTSP, pôrod, and rizikové faktory
- Language:
- Czech
- Description:
- Zhrnutie. Cieľom tohto prehľadového článku je popísať objektívne pôrodnícke a populačné faktory, ktoré sa podieľajú na vzniku posttraumatickej stresovej poruchy (PTSP) po pôrode, a tiež spôsoby, akými sa vzájomne ovplyvňujú so subjektívnymi faktormi, s cieľom identifikovať ženy, u ktorých je zvýšené riziko rozvoja symptómov PTSP po pôrode. Výsledky. Výskyt PTSP 4 až 6 týždňov po pôrode sa odhaduje na 5,77 % v celkovej populácii žien po pôrode a na 12,64 % v rizikovej subpopulácii. Pôrodnícke faktory sa javia byť do značnej miery mediované emocionálnou podporou rodiacej ženy zo strany zdravotníckeho personálu, ako aj prítomnosťou a podporou sprevádzajúcej osoby. Subjektívne vnímanie pôrodu rodiacimi ženami a miera kontroly, ktorú počas pôrodu pociťujú, patria medzi najsilnejšie faktory, ktoré ovplyvňujú riziko vzniku PTSP po pôrode. Včasná intervencia v podobe poskytovania dostatočných informácií a emocionálnej podpory počas pôrodu, ako aj v období po pôrode a rôzne formy sociálnej podpory znižujú riziko vzniku chronickej formy PTSP. Limity. Vzhľadom na špecifiká pôrodných systémov sa môže miera výskytu PTSP a zastúpenie rizikových faktorov v českom a slovenskom prostredí líšiť od výskytu a zastúpenia v krajinách, z ktorých pochádzajú zdroje zahrnuté v tomto prehľadovom článku. and Objectives. The aim of this article is to describe objective obstetric and population factors for the development of post-traumatic stress disorder (PTSD) after childbirth, the ways in which they interact with subjective factors, in order to identify those women who are at an increased risk of developing PTSD symptoms after delivery. Methods. The Web of Science database was used to search the literature. The keywords “posttraumatic stress disorder”, “PTSD”, “childbirth”, “trauma” and “risk factors” were entered. Out of 79 resulting articles in English, 48 articles dealing with the topic of postpartum PTSD were selected, of which 29 directly dealt with the identification and description of risk factors for the development of postpartum PTSD. Additional relevant literature has been obtained through the study of these articles. Results. The incidence of PTSD at 4-6 weeks after childbirth is estimated at 5.77% in the total population of postpartum women, and in the at-risk subpopulation, the estimate is 12.64%. Obstetric factors appear to be largely mediated by the emotional support of birthing woman from medical staff as well as by the presence and support of the accompanying person. Subjective perception of childbirth by the women giving birth, and the degree of control they feel during the birth process are among strongest factors which influence the risk of developing PTSD after childbirth. Early intervention in the form of providing comprehensive information and emotional support during childbirth, as well as in the postpartum period, and various forms of social support reduce the risk of developing a chronic form of PTSD. Study limitations. Due to the specifics of childbirth systems across geographies, the incidence rate of PTSD and the representation of risk factors in the Czech and Slovak environments can differ from the incidence and representation of those countries included in the resources for this review article.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public