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Start Over Subject collagenous proteins

2. Protein profiling of human atrial and ventricular musculature: the effect of normoxaemia and hypoxaemia in congenital heart diseases

Creator:
Pelouch, V., Milerová, M., Ošťádal, B., Šamánek, M., and Hučín, B.
Type:
article, model:article, and TEXT
Subject:
protein profiling of cardiac muscle, contractile proteins, collagenous proteins, ATPase of atrial and ventricular myosin, congenital heart disease, tetralogy of Fallot, ventricular septal defect, and atrial septal defect
Language:
English
Description:
Samples of myocardial tissue were obtained during surgical intervention from children operated for different types of congenital heart disease (tetralogy of Fallot, ventricular and atrial septal defect). Sarcoplasmic, contractile and collagenous proteins were isolated by stepwise extraction from the both right ventricular and atrial musculature. It has been found that: a) the concentration of contractile proteins is significantly higher in the ventricles, b) the concentration of collagenous proteins is significantly higher in the atrium, c) the concentration of sarcoplasmic proteins was not different, d) in children with chronic hypoxia the above atrio-ventricular differences persisted. Moreover, the proportion of the soluble collagenous fraction in the atria was significantly increased.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Protein profiling of the myocardium exposed to pressure overload from birth

Creator:
Černohorský, J., Pelouch, V., Milerová, M., and Ošťádal, B.
Type:
article, model:article, and TEXT
Subject:
myocardium, pressure overload, aorta banding, types of collagen, myosin light chains, protein profile, collagenous proteins, and non-collagenous proteins
Language:
English
Description:
Aortic banding induced in 2-day-old (A2) and 6-day-old (A6) male rats increased the left ventricular (LV) weight after 60 days; right ventricular (RV) enlargement occurred in the A2 group only. The concentration of collagenous proteins in the LV was elevated in both experimental groups (more in the A2 rats) at the expenses of sarcoplasmic proteins. Aortic banding also affected the proportion of collagen types (lower collagen I, higher collagen 111, V) and myosin light chains (higher LC1/LC2) in the LV. Similar changes of proteins in the RV were less pronounced.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public