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1. Response of human HTB140 melanoma cells to conventional radiation and hadrons

Creator:
Ristić-Fira, A., Todorović, D., Žakula, J., Keta, O., Cirrone, P., Cuttone, G., and Petrović, I.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, protony, přežití, protons, survival, carbon ions, HTB140 melanoma, proliferation, 14, and 612
Language:
English
Description:
Conventional radiotherapy with X- and γ-rays is one of the common and effective treatments of cancer. High energy hadrons, i.e., charged particles like protons and 12C ions, due to their specific physics and radiobiological advantages are increasingly used. In this study, effectiveness of different radiation types is evaluated on the radio-resistant human HTB140 melanoma cells. The cells were irradiated with γ-rays, the 62 MeV protons at the Bragg peak and in the middle of the spread-out Bragg peak (SOBP), as well as with the 62 MeV/u 12 C ions. The doses ranged from 2 to 24 Gy. Cell survival and proliferation were assessed 7 days after irradiation, whereas apoptosis was evaluated after 48 h. The acquired results confirmed the high radio-resistance of cells, showing better effectiveness of protons than γ-rays. The best efficiency was obtained with 12C ions due to higher linear energy transfer. All analyzed radiation qualities reduced cell proliferation. The highest proliferation was detected for 12C ions because of their large killing capacity followed by small induction of reparable lesions. This enabled unharmed cells to preserve proliferative activity. Irradiations with protons and 12C ions revealed similar moderate pro-apoptotic ability that is in agreement with the level of cellular radio-resistance., A. Ristić-Fira ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Synchrofázotron Akademie věd SSSR na energie do 10 BeV

Creator:
Veksler, Vladimir Iosifovič, Jefremov, D. B., Minc, A. L., Vejsbejn, M. M., Vodopjanov, F. A., Gašev, M. A., Zejdlic, A. I., Ivanov, P. P., Kolomenskij, A. A., Komar, J. G., Malyšev, I. F., Monoszon, A., Něvjažskij, I. Ch., Petuchov, V. A., Rubčinskij, S. M., Sinělnikov, K. D., Stolov, A. M., and Veselka, Josef
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
Akademie věd SSSR, referáty, protony, urychlovače, jaderná fyzika, reports, protons, accelerators, nuclear physics, fyzika částic, synchrofázotron, lineární urychlovače, historie fyziky, history of physics, 6, and 53
Language:
Czech and Russian
Description:
V. J. Veksler, D. B. Jefremov, A. L. Minc, M. M. Vejsbejn, F. A. Vodopjanov, M. A. Gašev, A. I. Zejdlic, P. P. Ivanov, A. A. Kolomenskij, J. G. Komar, I. F. Malyšev, A. Monoszon, I. Ch. Něvjažskij, V. A. Petuchov, M. S. Rabinovič, S. M. Rubčinskij, K. D. Sinělnikov, A. M. Stolov ; volně přeložil Josef Veselka., Referát přednesený na Všesvazové konferenci o fyzice částic vysokých energií, Moskva 1956, Obsahuje: referát, který byl otištěn v časopise Atomnaja eněrgija [1(4), 67 (1956)] i český překlad uveřejněný v Pokrocích matematiky, fyziky a astronomie [2(1), 67 (1957)], and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public