Molecular pathways of endoplasmic reticulum dysfunctions: possible cause of cell death in the nervous system

Title:

Molecular pathways of endoplasmic reticulum dysfunctions: possible cause of cell death in the nervous system

Creator:

Ján Lehotský, Peter Kaplán, Eva Babušíková, Anna Strapková, and Murín, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:32cefc1f-1919-4979-8ac7-9d47744a2868
uuid:32cefc1f-1919-4979-8ac7-9d47744a2868
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, neurony, neurons, endoplasmic reticulum, calcium store, damage, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

This review summarizes recent information on the role of calcium in the process of neuronal injury with special attention to the role of calcium stores in the endoplasmic reticulum (ER). Experimental results present evidence that ER is the site of complex processes such as calcium storage, synthesis and folding of proteins and cell response to stress. ER function is impaired in many acute and chronic diseases of the brain which in turn induce calcium store depletion and conserved stress responses. Understanding the mechanisms leading to ER dysfunction may lead to recognition of neuronal protection strategies., J. Lehotský, P. Kaplán, E. Babušíková, A. Strapková, R. Murín., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:3

Harvested from:

CDK

Metadata only:

false