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472. Pentastome assemblages of the Nile crocodile, Crocodylus niloticus Laurenti (Reptilia: Crocodylidae), in the Kruger National Park, South Africa

Creator:
Junker, Kerstin, Calitz, Frikkie, Govender, Danny, Boris Ronal'dovič Krasnov, and Boomker, Joop
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
parazitologie, parasitology, Alofia, Leiperia, Sebekia, Pentastomida, abundance, prevalence, species richness, crocodilians, 2, and 59
Language:
English
Description:
Thirty-two specimens of the Nile crocodile, Crocodylus niloticus Laurenti (Reptilia: Crocodylidae), from the Kruger National Park, South Africa, and its vicinity were examined for pentastomid parasites during 1995 to 1999 and 2010 to 2011. Pentastomid parasites occurred throughout the year and were widespread in the study area with an overall prevalence of 97% and an overall mean abundance of 23.4 (0-81). Pentastome assemblages comprised six species in three sebekid genera: Alofia nilotici Riley et Huchzermeyer, 1995, A. simpsoni Riley, 1994, Leiperia cincinnalis Sambon, 1922, Sebekia cesarisi Giglioli in Sambon, 1922, S. minor (Wedl, 1861) and S. okavangoensis Riley et Huchzermeyer, 1995. The possible influence of host age, gender and geographic location (river system) on pentastome prevalence, abundance and species richness was investigated. Generally, neither host age, gender nor locality did affect infracommunities, likely because all hosts examined were adult or subadult and displayed comparable foraging behaviour, resulting in similar exposure pathways to fish intermediate hosts. Additionally, the longevity of pentastomids would contribute to accumulative infections as hosts mature. Structuring of pentastome assemblages was observed in as far as S. minor was the dominant species based on overall prevalence and abundance, followed by the equally common species S. cesarisi and L. cincinnalis. With an overall prevalence ranging from 34% to 41% and relatively low abundances, A. nilotici, A. simpsoni and S. okavangoensis form the rarer component of pentastome communities., Kerstin Junker, Frikkie Calitz, Danny Govender, Boris R. Krasnov, Joop Boomker., and Obsahuje bibliografii
Rights:
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473. Perinatal hypoxic-ischemic damage: overview and current treatment possibilities

Creator:
Frajewicki, Ari, Laštůvka, Zdeněk, Borbélyová, Veronika, Khan, Sami, Jandová, Kateřina, Janišová, Kateřina, Otáhal, Jakub, Mysliveček, Jaromír, and Riljak, Vladimír
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
hypoxia, hypoxic-ischemic encephalopathy, immature brain, and treatment
Language:
English
Description:
Neonatal hypoxic-ischemic encephalopathy is a disorder with heterogeneous manifestation due to asphyxia during perinatal period. It affects approximately 3-12 children per 1000 live births and cause death of 1 million neonates worldwide per year. Besides, motor disabilities, seizures, impaired muscle tone and epilepsy are few of the consequences of hypoxic-ischemic encephalopathy. Despite an extensive research effort regarding various treatment strategies, therapeutic hypothermia with intensive care unit supportive treatment remains the only approved method for neonates who have suffered from moderate to severe hypoxicischemic encephalopathy. However, these protocols are only partially effective given that many infants still suffer from severe brain damage. Thus, further research to systematically test promising neuroprotective treatments in combination with hypothermia is essential. In this review, we discussed the pathophysiology of hypoxic-ischemic encephalopathy and delved into different promising treatment modalities, such as melatonin and erythropoietin. However, preclinical studies and clinical trials are still needed to further elucidate the mechanisms of action of these modalities.
Rights:
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474. Peroxisome proliferator-activated receptor γ in white and brown adipocyte regulation and differentiation

Creator:
Wu, Hui, Li, Xiaohua, and Shen, Chunyan
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
fyziologie, physiology, differentiation regulation, PPARγ, adipocytes, white adipose tissue, brown adipose tissue, 14, and 612
Language:
English
Description:
In as early as 1997, the World Health Organization officially recognized obesity as a chronic disease. The current epidemic of obesity and overweightness has aroused great interest in the study of adipose tissue formation. The transcription factor peroxisome proliferator-activated receptor γ (PPARγ) binds to the target gene promoter regulatory sequences, acting as a key factor in regulating the differentiation of preadipocytes in the adipose tissue, and plays an important role in regulating the adipocyte metabolism. A further understanding of the structure and expression characteristics of PPARγ, in addition to its mechanisms of action in adipocyte differentiation, may be applied to control obesity and prevent obesity-related diseases. In this article, recent studies investigating the effect of regulating PPARγ on adipocyte differentiation are reviewed. In particular, the structural characteristics, expression patterns, and molecular mechanisms of PPARγ function in adipocyte differentiation are considered., Hui Wu, Xiaohua Li, Chunyan Shen., and Obsahuje bibliografii
Rights:
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476. Pharmacological stimulation of Wnt/beta-catenin signaling pathway attenuates the course of thioacetamide-induced acute liver failure

Creator:
Koblihová, Eva, Mrázová, Iveta, Vaňourková, Zdenka, Maxová, Hana, Kikerlová, Soňa, Husková, Zuzana, Ryska, Miroslav, Froněk, Jiří, and Vernerová, Zdenka
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
acute liver failure, thioacetamide, and Wnt/β-catenin signaling pathway
Language:
English
Description:
Acute liver failure (ALF) is known for extremely high mortality rate, the result of widespread damage of hepatocytes. Orthotopic liver transplantation is the only effective therapy but its application is limited by the scarcity of donor organs. Given the importance in the liver biology of Wnt/β-catenin signaling pathway, we hypothesized that its stimulation could enhance hepatocyte regeneration and attenuate the course of thioacetamide (TAA)-induced ALF in Lewis rats. Chronic treatment with Wnt agonist was started either immediately after hepatotoxic insult (“early treatment”) or when signs of ALF had developed (“late treatment”). Only 23 % of untreated Lewis rats survived till the end of experiment. They showed marked increases in plasma alanine aminotransferase (ALT) activity and bilirubin and ammonia (NH3) levels; plasma albumin decreased significantly. “Early” and “late” Wnt agonist treatment raised the final survival rate to 69 % and 63 %, respectively, and normalized ALT, NH3, bilirubin and albumin levels. In conclusion, the results show that treatment with Wnt agonist attenuates the course of TAA-induced ALF in Lewis rats, both with treatment initiated immediately after hepatotoxic insult and in the phase when ALF has already developed. Thus, the pharmacological stimulation of Wnt/β-catenin signaling pathway can present a new approach to ALF treatment.
Rights:
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477. Pharmacological suppression of endogenous glucocorticoid synthesis attenuated blood pressure and heart rate response to acute restraint in Wistar rats

Creator:
Bencze, Michal, Vavřínová, Anna, Zicha, Josef, and Behuliak, Michal
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
stress, adrenalectomy, metyrapone, aminoglutethimide, corticosterone, blood pressure, and heart rate
Language:
English
Description:
Glucocorticoids (GCS) are known to modulate cardiovascular response during stress conditions. The present study was aimed to test the hypothesis that permissive and/or stimulating effect of GCs is essential for the maintenance of peripheral vascular resistance and for the adequate response of cardiovascular system to stressor exposure. The effects of acute pharmacological adrenalectomy (PhADX) on humoral and cardiovascular parameters were studied in adult Wistar rats under the basal conditions and during the acute restraint stress. Acute PhADX was performed by the administration of metyrapone and aminoglutethimide (100 mg/kg s.c. of each drug) resulting in a suppression of endogenous glucocorticoid synthesis. Blood pressure (BP), heart rate (HR) and core body temperature were measured using radiotelemetry. BP responses to administration of vasoactive agents were determined in pentobarbital-anesthetized animals. PhADX considerably attenuated stress-induced increase of BP, HR and core body temperature. PhADX did not abolish BP and HR lowering effects of ganglionic blocker pentolinium indicating preserved sympathetic function in PhADX rats. BP response to exogenous norepinephrine administration was attenuated in PhADX rats, suggesting reduced sensitivity of cardiovascular system. Suppression of corticosterone synthesis by PhADX increased basal plasma levels of ACTH, aldosterone and plasma renin activity in unstressed animals but there was no further increase of these hormones following stressor exposure. In conclusion, PhADX attenuated stress-induced rise of blood pressure, heart rate and core body temperature indicating an important permissive and/or stimulating role of glucocorticoids in the maintenance of the adequate response of cardiovascular system and thermoregulation to several stimuli including acute exposure to stressor.
Rights:
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478. Phenotypic pattern over centric fusion clinal variation in the water-hyacinth grasshopper, Cornops aquaticum (Orthoptera: Acrididae)

Creator:
Colombo, Pablo C and Remis, María I
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
rovnokřídlí, Orthoptera, Acrididae, Cornops aquaticum, centric fusions, grasshoppers, chromosomal clines, morphometric effects, 2, and 59
Language:
English
Description:
The water-hyacinth grasshopper, Cornops aquaticum, occurs in freshwater environments in the New World between latitudes 23°N and 35°S. At the southernmost margin of this distribution the populations are polymorphic for three centric fusions (Robertsonian translocations). The frequencies of these chromosome rearrangements increase southwards and the recombination in structural homozygotes and heterozygotes diminishes both along the middle and lower courses of the Paraná River. In the present paper we report a similar cline along the southward flowing Uruguay River. In addition, we report the morphological effects of two of these centric fusion polymorphisms, namely the fusions between chromosomes 2 and 5 of the standard complement (fusion 2/5) and chromosomes 3 and 4 (fusion 3/4) and extend this study to the Uruguay River. There is a strong inverse correlation of fusion frequency with temperature, which indicates that these polymorphisms may be related to increased tolerance of colder climates in this originally tropical species, or some other correlated variable. This study is a further example of chromosomal clines correlated with latitude and is one of a few examples of chromosome polymorphisms associated with phenotypic effects. Finally, it indicates ways of using this species for controlling pests., Pablo C. Colombo, María I. Remis., and Obsahuje bibliografii
Rights:
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479. Plasma levels of adipokines in patients with Alzheimer’s disease: Where is the "breaking point" in Alzheimer’s disease pathogenesis?

Creator:
Vaňková, Markéta, Vacínová, Gabriela, Včelák, Josef, Vejražková, Daniela, Lukášová, Petra, Rusina, Robert, Holmerová, Iva, Jarolímová, Eva, Vaňková, Hana, and Bendlová, Běla
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
Alzheimerova choroba, leptin, Alzheimer's disease, adiponectin, adipsin, bloodbased biomarker, 14, and 612
Language:
English
Description:
Peripheral insulin resistance is associated with decreasing adiponectin and increasing leptin plasma levels, and also with cognitive decline. The effects of adipokines on brain function have been published from both animal and human studies. In particular, the influence of leptin and adiponectin on the development of Alzheimer’s disease (AD) has been extensively investigated. However, the association between adipsin and AD is as yet unknown. In 37 patients with AD and 65 controls that followed the same study protocol, we tested whether adiponectin, leptin, and adipsin could be used as biomarkers in the early stages of AD. In contrast with conclusions of cognition studies in insulin resistant states, our study found a correlation of impaired neuropsychological performance with increasing adiponectin and decreasing leptin in AD patients. Nevertheless, no significant differences between patients and controls were found. AD women had significantly increased adipsin compared to controls, and there was a positive correlation of adipsin with age and disease duration. Although adipokines do not appear to be suitable biomarkers for early AD diagnosis, they certainly play a role in the pathogenesis of AD. Further studies will be needed to explain the cause of the adipokine “breaking point” that leads to the pathogenesis of overt AD., Markéta Vaňková, Gabriela Vacínová, Josef Včelák, Daniela Vejražková, Petra Lukášová, Robert Rusina, Iva Holmerová, Eva Jarolímová, Hana Vaňková, Běla Bendlová., and Obsahuje bibliografii
Rights:
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480. Political party membership and personality characteristics in the Czech republic (2005)

Creator:
Linkov, Václav
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
five-factor model, political preferences, Czech political parties, pětifaktorový model, politické preference, and české politické strany
Language:
Czech
Description:
This paper examines the relationship between Big Five personality dimensions and membership in political parties in the Czech Republic. A total of 194 members from eight major Czech political parties filled out the NEO Five-Factor Inventory to assess the Big Five personality dimensions. The mean scores of the respondents from each party were compared to the scores of a sample of the general Czech population. The members of three right-wing parties scored lower in agreeableness and the members of one left-wing party were higher in agreeableness than the general population, which is consistent with results from other countries. The Greens scored higher in openness than the general population, which is consistent with results from Germany. Members of former governing parties, which had long been out of power, scored lower in neuroticism than the general population. and V článku se zabýváme vztahem mezi osobností a členstvím v českých politických stranách. Sto devadesát čtyři členů osmi hlavních českých politických stran vyplnilo NEO – pětifaktorový osobnostní inventář. Průměrné skóry členů každé strany byly porovnány se skóry vzorku české populace. Členové tří pravicových stran skórovali níže než populace v přívětivosti, členové jedné levicové strany naopak v přívětivosti skórovali výše. To je v souladu se vztahem mezi levicovostí a přívětivostí zjištěným v jiných zemích (např. Itálie). Zelení skórovali výše než populace v otevřenosti, což souhlasí s podobným zjištěním v Německu. Členové dřívějších vládních stran, jejichž vládní angažmá skončilo před dlouhou dobou, skórovali níže v neuroticismu než česká populace.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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