Parkinson's disease (PD) is most commonly manifested by the
presence of motor symptoms. However, non-motor symptoms
occur several years before the onset of motor symptoms
themselves. Hallmarks of dysfunction of the respiratory system are
still outside the main focus of interest, whether by clinicians or
scientists, despite their indisputable contribution to the morbidity
and mortality of patients suffering from PD. In addition, many of
the respiratory symptoms are already present in the early stages
of the disease and efforts to utilize these parameters in the early
diagnosis of PD are now intensifying. Mechanisms that lead to the
development and progression of respiratory symptoms are only
partially understood. This review focuses mainly on the
comparison of respiratory problems observed in clinical studies
with available findings obtained from experimental animal models.
It also explains pathological changes observed in non-neuronal
tissues in subjects with PD.
Respiratory sinus arrhythmia (RSA), i.e. heart rate (HR) variations
during inspiration and expiration, is considered as a noninvasive
index of cardiac vagal control. Mitral valve prolapse (MVP) could
be associated with increased cardiovascular risk; however, the
studies are rare particularly at adolescent age. Therefore, we
aimed to study cardiac vagal control indexed by RSA in adolescent
patients suffering from MVP using short-term heart rate variability
(HRV) analysis. We examined 12 adolescents (girls) with MVP (age
15.9±0.5 years) and 12 age and gender matched controls. Resting
ECG was continuously recorded during 5 minutes. Evaluated HRV
indices were RR interval (ms), rMSSD (ms), pNN50 (%), log HF
(ms2
), peak HF (Hz) and respiratory rate (breaths/min). RR interval
was significantly shortened in MVP group compared to controls
(p=0.004). HRV parameters-rMSSD, pNN50 and log HF were
significantly lower in MVP compared to controls (p=0.017,
p=0.014, p= 0.015 respectively). Our study revealed reduced RSA
magnitude indicating impaired cardiac vagal control in MVP already
at adolescent age that could be crucial for early diagnosis of
cardiovascular risk in MVP.
Ketamine, an N-methyl-D-aspartate antagonist, reduces pain by decreasing central sensitization and pain windup. However, chronic ketamine use can cause tolerance, dependency, impaired consciousness, urinary symptoms, and abdominal pain. This study aimed to investigate the effects of repeated ketamine injections and ketamine readministration after discontinuation in a rat model of neuropathic pain. To induce neuropathic pain, partial sciatic nerve ligation (PSNL) was performed in 15 male Wistar rats, and these animals were divided into three groups: PSNL (control), PSNL + ketamine 5 mg/kg (K5), and PSNL + ketamine 10 mg/kg (K10; n=5 each). Ketamine was injected intraperitoneally daily for 4 weeks, discontinued for 2 weeks, and then readministered for 1 week. Following PSNL, the mechanical withdrawal threshold was determined weekly using the Von Frey. The K10 group showed a significant increase in the mechanical withdrawal threshold, presented here as the target force (in g), at 21 and 28 days compared to the time point before ketamine injection (mean±SE, 276.0±24.0 vs. 21.6±2.7 and 300.0±0.0 vs. 21.6±2.7, respectively; P<0.01) and at 14, 21, and 28 days compared to the control group (108.2±51.2 vs. 2.7±1.3, 276.0±24.0 vs. 2.5±1.5, and 300.0±0.0 vs. 4.0±0.0, respectively; P<0.05). However, in the K10 group, the ketamine effects decreased significantly at 7 days after readministration compared to those after 28 days of repeated injections (P<0.05). In the K10 group, repeated ketamine injections showed a significant increase in antinociceptive effect for >2 weeks, but this ketamine effect decreased after drug readministration.
We studied the effects of the overstory canopy cover on ground-dwelling harvestmen communities in European beech forests in the Western Carpathian Mts. We analyzed the differences in species richness, abundance and composition in two tree canopy cover categories (closed and open canopy). Overall, 1765 individuals belonging to 16 species were caught using pitfall traps. Repeated-measures ANOVA revealed that under both closed and open canopies a similar absolute and rarefied species richness and number of individuals (standardized to 100 pitfall trap days) were caught, and that both species richness and abundance were affected by the season (i.e., time of trap replacement); yet the total number of individuals trapped was more than two times greater under the open canopy than under the closed canopy. Despite the subtle differences in the taxonomic composition of the catches under the open and closed canopies revealed by DCA followed by RDA, the composition of ground-dwelling harvestmen assemblages differed under the two canopy covers. The open canopy was more suitable for heliophilic, xerothermic eurytopic harvestmen species typical for open and ecotonal habitats, such as Egaenus convexus (C.L. Koch) and Oligolophus tridens (C.L. Koch) but still suitable for hemihygrophilic Lophopilio palpinalis (Herbst). The closed canopy stands were preferred by shade-tolerant, hygrophilic eurytopic harvestmen species, such as Trogulus sp. Latreille, Dicranolasma scabrum (Herbst) and Platybunus bucephalus (C.L. Koch). Our results highlight the importance of intra-habitat heterogeneity of a harvestmen community., Ľudmila Černecká, Ivan Mihál, Benjamín Jarčuška., and Obsahuje bibliografii
Heat stress has become more common in recent years, limiting wheat production in Huang-Huai-Hai plain in China. To identify the effect of long-term heat stress on wheat production, two heat-resistant (JM44, JM23) and two heat-sensitive (XM26, GC8901) wheat varieties were sown in heat tents and normal conditions, and heat stress (9 to 12℃ higher than control) was imposed for seven days at post-anthesis. All varieties under heat stress exhibited early senescence and reduced grain-filling rate, while the grain-filling period of heat-tolerant varieties was longer than that of the heat-sensitive. Furthermore, long-term heat stress significantly reduced kernel mass, grain number, harvest index, chlorophyll content, maximum quantum yield of PSⅡ photochemistry, effective quantum yield of PSⅡ photochemistry, photosynthetic rate, and transpiration efficiency. In addition, the distribution of dry matter to vegetative organs, catalase activity, and malondialdehyde content increased. These results indicated that the lesser yield reduction of heat-resistant varieties (11-26%) than that of heat-sensitive (16-37%) is due to relatively higher antioxidative and photosynthetic performance and higher assimilation in the grain from vegetative organs.
The Loess Plateau is the main source of water in Yellow River, China. After 1980s, the Yellow river water presented a significant reduction, what caused the decrease of the Yellow river discharge had been debated in academic circles. We proceeded with runoff generation mechanisms to explain this phenomenon. We built saturation excess runoff and infiltration excess runoff generation mechanisms for rainfall–runoff simulation in Jingle sub-basin of Fen River basin on the Loess Plateau, to reveal the influence of land use change on flood processes and studied the changes of model parameters under different underlying conditions. The results showed that the runoff generation mechanism was mainly infiltration-excess overland flow, but the flood events of saturation-excess overland flow had an increasing trend because of land use cover change (the increase of forestland and grassland areas and the reduction of cultivated land). Some of the model parameters had physical significances，such as water storage capacity (WM), infiltration capacity (f), evapotranspiration (CKE), soil permeability coefficient (k) and index of storage capacity distribution curve (n) showed increasing trends, and index of infiltration capacity distribution curve (m) showed a decreasing trend. The above results proved the changes of runoff generation mechanism from the perspective of model parameters in Jingle sub-basin, which can provide a new perspective for understanding the discharge reduction in the Yellow River basin.
In Indian agro-ecosystems Rhynocoris marginatus (F.) is one of the most abundant predatory arthropods and feeds on a wide range of insect pests. We investigated the responses of R. marginatus to six species of cotton pests: Spodoptera litura (F.), Sylepta derogata (F.), Pericallia ricini (F.), Mylabris indica (Thunberg), Mylabris pustulata (Thunberg) and Dysdercus cingulatus (F.), in terms of its predatory behaviour (approach and handling times), weight gain, macromolecular profile (content of carbohydrates, proteins, free aminoacids and lipids) and haemocytic profile. We also determined the predator's reliance on kairomones from different species of prey. Larvae of the species of Lepidoptera studied were approached and captured more quickly than adults of the two meloid coleopteran and one heteropteran pest and were more beneficial to the predator in terms of weight gain. Predators had a higher total protein content when reared on larvae of the three lepidopteran species, higher lipid content when reared on adults of the two meloid coleopteran species and a higher carbohydrate content when reared on adults of one heteropteran species. The number of haemocytes was greater in predators reared on larvae of the Lepidoptera studied, followed by those reared on adults of the heteropteran and lowest in those reared on adults of the two meloid coleopterans. Response to kairomones was strongest for S. litura followed by S. derogata and M. pustulata. We conclude that the Lepidoptera studied tended to be, for this predator, superior prey, with S. litura being especially beneficial and the prey species for which R. marginatus has the highest kairomonal preference. Moreover, we propose that R. marginatus may be useful as a biocontrol agent against lepidopteran cotton pests., Kitherian Sahayaraj, Subramanian Muthu Kumar, Annie Enkegaard., and Obsahuje bibliografii
The sustainable production of upland cotton, an economically important fiber crop, is threatened by changing environmental factors including high temperatures and low-soil water content. Both high heat and low-soil water can reduce net photosynthesis resulting in low fiber yields or poor fiber quality. Leaf chlorophyll content has a direct relationship with photosynthetic rate. Understanding how high heat and low-soil water affect chlorophyll content can identify opportunities for breeding improvement that will lead to sustainable fiber yields. A two-year field trial located in Maricopa Arizona measured leaf chlorophyll content, available soil water, ambient air temperatures, and cotton growth measurements collected by a high-clearance tractor equipped with proximal sensors. The results showed that low-soil water significantly increased leaf chlorophyll content, while high temperatures significantly reduced content. Structured equation modeling revealed that cotton may divert available resources to leaf area and chlorophyll content for the production of photosynthates during periods of high temperatures.
Housing regime’ is a term that is used relatively often in (macrosocial) research comparing housing policies and systems. However, there is no generally accepted definition of this term. In this paper I shall first scrutinise previous uses of the concept, starting with a discussion of the most famous regime concept – the welfare regime. The discussion paves the way for a redefinition of a ‘housing regime’: the set of fundamental principles according to which housing provision operates in some defined area (municipality, region, state) at a particular point in time. Such principles are thought to be embodied in the institutional arrangements that relate to housing provision, in the political interventions that address housing issues, and as in the discourses through which housing issues are customarily understood. This definition is compatible with the path-dependence approach that has been adopted here and with the aspects of reality that researchers want to capture using the ‘regime’ concept.
The general status of lampreys (family Petromyzontidae) in Bosnia and Herzegovina was reviewed to determine the species composition and geographical distribution of this group in the region. This paper reviews the available literature to provide a critical analysis of the current status of lamprey species. According to the available data, their status can be considered as indeterminate, largely due to limited published records. While eight species are recorded as present in the region (Eudontomyzon danfordi, E. mariae, E. vladykovi, Lampetra fluviatilis, L. planeri, L. soljani, Lethenteron zanandreai, Petromyzon marinus), only three species (E. vladykovi, L. soljani, P. marinus) are confirmed to occur. Their distribution is recorded in waters of both the Danube and the Adriatic Sea catchments. Given the deficiencies in our understanding of the taxonomic status of some populations and knowledge of the geographical distribution of lampreys inhabiting both catchments, research focused on improving understanding of the phylogenetic, morphological and phenotypic traits of lampreys in Bosnia and Herzegovina is warranted to resolve these uncertainties. Problems related to threats and conservation, and future perspectives for protective management strategies are discussed. This paper provides the context for future biodiversity conservation and management with regard to lamprey species in Bosnia and Herzegovina.