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1733. Vznik a význam snů ve zdraví i chorobě

Creator:
Antonín Wiesner
Publisher:
Nákladem J. Otty
Format:
print and 33 s.
Type:
model:monograph and TEXT
Subject:
Patologie. Klinická medicína, Psychopatologie, sny, psychoanalytické aspekty, snová symbolika, výklad snů, dreams, psychoanalytical aspects, dream symbolism, dream interpretation, 616.8-009.836.15, 159.963.38, (0.062), 14, 17, 616, and 159.97
Language:
Czech
Description:
napsal Antonín Wiesner. and KČSN
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1735. What is the role of neurotransmitter systems in cortical seizures?

Creator:
Pavel Mareš and Hana Kubová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, neurofyziologie, epileptologie, farmakologie, neurophysiology, epileptology, pharmacology, cortical epileptic afterdischarges, GABA, glutamate, immature rats, 14, and 612
Language:
English
Description:
Epileptic afterdischarges (ADs) elicited by electrical stimulation of sensorimotor cortical area were used as a model to study the role of neurotransmitter systems in cortical seizures in three age groups of developing rats. Drugs augmenting inhibition mediated by GABAA receptors were found to suppress ADs in all age groups, their activity was usually more marked in younger than in 25-day-old rat pups. Drugs potentiating GABAB receptors exhibit lower efficacy and more complicated developmental profile than GABAA-ergic drugs. Effects of an antagonist of GABAB receptor – marked prolongation of ADs in all three age groups – suggest an important role of GABAB receptors in arrest of cortical seizures. Drugs affecting glutamate receptors exhibit variable effects, usually better expressed in older animals than in 12-day-old ones. No specific role for ionotropic as well as metabotropic glutamate receptors could be predicted. Activation of adenosinergic inhibitory modulatory system also exhibited anticonvulsant action in the present model. All three neurotransmitter systems probably participate in mechanisms of generation, maintenance and arrest of cortical seizures., P. Mareš, H. Kubová., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1736. What is the source of free radicals causing hemolysis in stored blood?

Creator:
Jaroslav Racek, Růžena Herynková, Václav Holeček, Faltysová, J., and Krejčová, I.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, volné radikály, leukocyty, hemolýza, free radicals, leucocytes, hemolysis, 14, and 612
Language:
English
Description:
The quality of stored blood can be deteriorated by hemolysis caused by free radicals. The purpose of this study was to elucidate whether neutrophile leukocytes are the source of free radicals in stored blood as in hemodialyzed patients. Resuspensions with low (LL) or high (HL) leukocyte concentrations were prepared from samples of twenty healthy volunteers. The samples were incubated for 10 days at 4 °C and then for one day at 37 °C. Markers of hemolysis and free radical metabolism were examined before and after incubation in LL and HL samples. In spite of the difference of leukocytes counts in LL and HL resuspensions (p<0.0001), the pre-incubation values of all laboratory parameters were practically identical. In post-storage samples, superoxide dismutase and glutathione peroxidase activities did not differ in either group. Reduced glutathione in erythrocytes and extracellular antioxidant capacity were insignificantly lower in HL resuspensions, but the increase of malondialdehyde was much more pronounced in the HL samples (p<0.0001). The degree of hemolysis, expressed as the extracellular increase of potassium (p<0.001), hemoglobin (p<0.05) and lactate dehydrogenase (p<0.05), was higher in the HL samples. Our results support the hypothesis that leukocytes participate in free radical production in stored blood., J. Racek, R. Herynková, V. Holeček, J. Faltysová, I. Krejčová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1737. When tradition meets innovation five decades of research at the Department of Physiology in Martin

Creator:
Andrea Čalkovská and Kamil Javorka
Format:
print, bez média, and svazek
Type:
article, úvodníky, editorials, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, vědecké instituce a organizace, physiology, scientific institutions and organizations, Martin (Slovensko), Martin (Slovakia), 14, and 612
Language:
English
Description:
Andrea Calkovska, Kamil Javorka.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1738. Whole exome sequencing analysis of ABCC8 and ABCD2 genes associating with clinical course of breast carcinoma

Creator:
Soucek, P., Hlavac, V., Elsnerova, K., Radka Václavíková, Kozevnikovova, R., and Raus, K.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, rakovina prsu, maligní nádorová onemocnění, sekvenování nové generace, terapie, breast cancer, cancer, pain therapy, next generation sequencing, ABC transporter, 14, and 612
Language:
English
Description:
The aim of the present study was to introduce methods for exome sequencing of two ATP-binding cassette (ABC) transporters ABCC8 and ABCD2 recently suggested to play a putative role in breast cancer progression and prognosis of patients. We performed next generation sequencing targeted at analysis of all exons in ABCC8 and ABCD2 genes and surrounding noncoding sequences in blood DNA samples from 24 patients with breast cancer. The revealed alterations were characterized by in silico tools. We then compared the most frequent functionally relevant polymorphism rs757110 in ABCC8 with clinical data of patients. In total, the study identified 113 genetic alterations (>70 % novel ones) in both genes. Of these alterations, 83 were noncoding, 13 synonymous, 10 frameshifts and 7 were missense alterations. Four in silico programs predicted pathogenicity of two polymorphisms and four newly identified alterations. Rs757110 polymorphism in ABCC8 did not significantly associate with clinical data of the patients. In conclusion, exome sequencing identified several functionally relevant alterations in ABCC8 and ABCD2 genes that may further be used for a larger follow-up study aiming to assess their clinical significance., P. Soucek, V. Hlavac, K. Elsnerova, R. Vaclavikova, R. Kozevnikovova, K. Raus., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1739. Why do we have purkinje fibers deep in our heart?

Creator:
Sedmera, D. and Gourdie, R. G.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, srdce, fyziologie, heart, physiology, 14, and 612
Language:
English
Description:
Purkinje fibers were the first discovered component of the cardiac conduction system. Origin ally described in sheep in 1839 as pale subendocardial cells, they were found to be present, although with different morphology, in all mammalian and avian hearts. Here we review differences in their appearance and extent in different species, summarize the current state of knowledge of their function, and provide an update on markers for these cells. Special emphasis is given to popular model species and human anatomy., D. Sedmera, R. G. Gourdie., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1740. Yet another decennium of the Institute of Physiology: a dynamic interplay of innovative approaches and 60 years of tradition

Creator:
Lucie Kubínová
Format:
print
Type:
article, zprávy, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, Fyziologický ústav (Akademie věd ČR), výročí, anniversaries, 14, and 612
Language:
English
Description:
L. Kubínová. and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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