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29102. Pfeffer A.: Zentral- und Westpaläarktische Borken- und Kernkäfer (Coleoptera: Scolytidae, Platypodidae)
- Creator:
- Švácha, P.
- Type:
- article, model:article, and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29103. Ph pozitivní akutní lymfoblastická leukemie dospělých
- Creator:
- Folber, František, Létalová, Eva, and Doubek, Michael
- Type:
- model:article, article, Text, přehledy, and TEXT
- Subject:
- lidé, lidé středního věku, dospělí, staří, akutní lymfatická leukemie--diagnóza--patofyziologie--terapie, filadelfský chromozom, buňky dřeně kostní--cytologie--patologie, cytogenetické vyšetření--metody, diagnostické techniky molekulární--metody, transplantace kmenových buněk, homologní transplantace, protokoly antitumorózní kombinované chemoterapie--škodlivé účinky--terapeutické užití, cytostatické látky--škodlivé účinky--terapeutické užití, asparaginasa--škodlivé účinky--terapeutické užití, radioterapie adjuvantní, protein-tyrosinkinasy--antagonisté a inhibitory--škodlivé účinky--terapeutické užití, monoklonální protilátky--terapeutické užití, prognóza, and léčba
- Language:
- Czech and English
- Description:
- Akutní lymfoblastická leukemie dospělých s pozitivitou filadelfského chromozomu a fúzního genu BCR/ABL je agresivní hematoonkologické onemocnění, typické pro pacienty vyššího věku. Léčba spočívá v podávání chemoterapie a inhibitoru tyrozinkinázy. Maximálního efektu lze dosáhnout pomocí alogenní transplantace krvetvorných buněk, tu je však schopna podstoupit jen malá část pacientů. V případě relapsu je prognóza onemocnění extrémně nepříznivá., Philadelphia chromosome positive adult acute lymphoblastic leukemia with BCR/ABL fusion gene is an aggressive hematological malignancy most common in the elderly. Both chemotherapy and a tyrosine kinase inhibitor are engaged in the treatment. The best outcome can eventually be achieved using allogeneic hematopoietic stem cell transplantation. However, only a minority of patients can undergo such intensive therapy. Disease relapse is associated with an extremely dismal prognosis., František Folber, Eva Létalová, Michael Doubek, and Lit.: 23
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29104. Phaenoglyphis "versus" Hemicrisis, and the description of a new sculptured species of Charipinae (Hymenoptera: Figitidae)
- Creator:
- Pujade-Villar, Juli and Paretas-martínez, Jordi
- Type:
- article, model:article, and TEXT
- Subject:
- Hymenoptera, Figitidae, Charipinae, Phaenoglyphis, Hemicrisis, new species, and Andorra
- Language:
- English
- Description:
- After comparing the morphology of the genus Hemicrisis Förster, 1869 and Phaenoglyphis Förster, 1869, and examining the sculpturing in this genus, the synonymy between Hemicrisis and Phaenoglyphis is re-established. The specific status of Phaenoglyphis pubicollis (Thomson, 1877) comb. n. is re-established and differentiated from Phaenoglyphis ruficornis (Förster, 1869) comb. n. A new species of Charipinae, Phaenoglyphis evenhuisi sp. n. is described from Andorra. It is characterized by the presence of sculpture on the mesonotum, a character only shared with P. pubicollis. Some illustrations are provided. Notes on all the sculptured Charipinae are provided as well as a key to the genera of Alloxystini.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29105. Phalacrotophora beuki (Diptera: Phoridae), a parasitoid of ladybird pupae (Coleoptera: Coccinellidae)
- Creator:
- Durska, Ewa, Ceryngier, Piotr, and Disney, R. Henry L.
- Type:
- article, model:article, and TEXT
- Subject:
- Phalacrotophora beuki, P. berolinensis, P. delageae, Phoridae, Anatis ocellata, Coccinellidae, and dipteran parasitoid
- Language:
- English
- Description:
- In the years 1998-2000, parasitization of the pupae of various ladybird species by scuttle flies of the genus Phalacrotophora was studied in central Poland. Altogether, 12 ladybird species were found to be parasitized by these flies, and one of them, Anatis ocellata (L.), proved to be a host of P. beuki Disney, a species whose biology had not previously been described. Our studies showed that P. beuki can limit the numbers of A. ocellata. In its typical habitat, i.e. Scots pine forests, 35-40% of this ladybird were parasitized by P. beuki. In other habitats, however, where A. ocellata occurred sporadically, P. beuki was not recorded from A. ocellata or other ladybird pupae. P. beuki was described from a single female collected in Holland. The present paper describes the hitherto unknown male, which is very similar to the males of P. berolinensis Schmitz and P. delageae Disney. The feature that reliably separates the males of these three species (a detail of the hypopygium) is described. This feature enabled the recognition in the collection of the Cambridge University Museum of Zoology of a male of P. beuki from Germany, previously assigned to P. berolinensis.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29106. Pharmacogenetic analysis of captopril effects on blood pressure: possible role of the Ednrb (endothelin receptor type B) candidate gene
- Creator:
- Josef Zicha, Zdena Dobešová, Václav Zídek, Šilhavý, J., Miroslava Šimáková, Petr Mlejnek, Ivana Vaněčková, Jaroslav Kuneš, and Michal Pravenec
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, krevní tlak, genetika, blood pressure, genetics, captopril, Ednrb gene, spontaneously hypertensive rat, 14, and 612
- Language:
- English
- Description:
- The objective of the current study was to search for genetic determinants associated with antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitor captopril. Linkage and correlation analyses of captopril-induced effects on blood pressure (BP) with renal transc riptome were performed in the BXH/HXB recombinant inbred (RI) strains derived from spontaneously hypertensive rat (SHR) and Brown Norway (BN-Lx) progenitors. Variability of blood pressure lowering effects of captopril among RI strains was continuous suggesting a polygenic mode of inheritance. Linkage analysis of captopril- induced BP effects revealed a significant quantitative trait locus (QTL) on chromosome 15. This QTL colocalized with cis regulated expression QTL (eQTL) for the Ednrb (endothelin receptor type B) gene in the kidney (SHR allele was associated with increased renal expression) and renal expression of Ednrb correlated with captopril-induced BP effects. These results suggest that blood pressure lowering effects of ACE inhibitor captopril may be modulated by the variants at the Ednrb locus., J. Zicha ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
29107. Pharmacokinetics of boldine in control and Mrp2-deficient rats
- Creator:
- Cermanova, J., Prasnicka, A., Dolezelova, E., Rozkydalova, L., Hroch, M., Chládek, A., Tomsik, P., Kloeting, I., and Micuda, S.
- Type:
- article, model:article, and TEXT
- Subject:
- Boldine, Mrp2, Pharmakokinecits, Elimination, and Bioavailibility
- Language:
- English
- Description:
- The aim of the present study was to describe the currently poorly understood pharmacokinetics (PK) of boldine in control rats (LW, Lewis rats), and Mrp2 transporter-deficient rats (TR-). Animals from the LW and TR- groups underwent a bolus dose study with 10 mg/kg of boldine applied either orally or intravenously in order to evaluate the major PK parameters. The TR- rats demonstrated significantly reduced total clearance with prolonged biological half-life (LW 12±4.6 versus TR - 20±4.4 min), decreased volume of distribution (LW 3.2±0.4 l/kg versus TR- 2.4±0.4 l/kg) and reduced bioavailability (LW 7 % versus TR- 4.5 %). Another set of LW and TR- rats were used for a clearance study with continuous intravenous administration of boldine. The LW rats showed that biliary and renal clearance formed less than 2 % of the total clearance of boldine. The treatment of samples with β-glucuronidase showed at least a 38 % contribution of conjugation reactions to the overall clearance of boldine. The TR- rats demonstrated reduced biliary clearance of boldine and its conjugates, which was partly compensated by their increased renal clearance. In conclusion, this study presents the PK parameters of boldine and shows the importance of the Mrp2 transporter and conjugation reactions in the elimination of the compound.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29108. Pharmacokinetics of leptin in female mice
- Creator:
- Hart, R. A., Dobos, R. C., Agnew, L. L., Tellam, R. L., and McFarlane, J. R.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, leptin, farmakokinetika, eliminace (chemie), pharmacokinetics, elimination, distribution, periphery, 14, and 612
- Language:
- English
- Description:
- Pharmacokinetics of leptin in mammals has received limited attention and only one study has examined more than two time points and this was in ob/ob mice. This study is the first to observe the distribution of leptin over a time course in female mice. A physiologic dose (12 ng) of radiolabelled leptin was injected in adult female mice via the lateral tail vein and tissues were dissected out and measured for radioactivity over a time course up to two hours. Major targets for administered leptin included the liver, kidneys, gastrointestinal tract and the skin while the lungs had high concentrations of administered leptin per gram of tissue. Leptin was also found to enter the lumen of the digestive tract intact from the plasma. Very little of the dose (<1 %) was recovered from the brain at any time. Consequently we confirm that the brain is not a major target for leptin from the periphery, although it may be very sensitive to leptin that does get to the hypothalamus. Several of the major targets (GI tract, skin and lungs) for leptin form the interface for the body with the environment, and given the ability of leptin to modulate immune function, this may represent a priming effect for tissues to respond to damage and infection., R. A. Hart, R. C. Dobos, L. L. Agnew, R. L. Tellam, J. R. McFarlane., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29109. Pharmacological inhibition of eIF2α phosphorylation by integrated stress response inhibitor (ISRIB) ameliorates vascular calcification in rats
- Creator:
- Dong, Jianlong, Jin, Sheng, Guo, Jingjing, Yang, Rui, Tian, Danyang, Xue, Hongmei, Xiao, Lin, Guo, Qi, Wang, Ru, Xu, Meng, Teng, Xu, and Wu, Yuming
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- vascular calcification, endoplasmic reticulum stress, eIF2, aorta, and ISRIB
- Language:
- English
- Description:
- Vascular calcification (VC) is an independent risk factor for cardiovascular events and all-cause mortality with the absence of current treatment. This study aimed to investigate whether eIF2α phosphorylation inhibition could ameliorate VC. VC in rats was induced by administration of vitamin D3 (3×105 IU/kg, intramuscularly) plus nicotine (25 mg/kg, intragastrically). ISRIB (0.25 mg/kg·week), an inhibitor of eIF2α phosphorylation, ameliorated the elevation of calcium deposition and ALP activity in calcified rat aortas, accompanied by amelioration of increased SBP, PP, and PWV. The decreased protein levels of calponin and SM22α, and the increased levels of RUNX2 and BMP2 in calcified aorta were all rescued by ISRIB, while the increased levels of the GRP78, GRP94, and C/EBP homologous proteins in rats with VC were also attenuated. Moreover, ISRIB could prevent the elevation of eIF2α phosphorylation and ATF4, and partially inhibit PERK phosphorylation in the calcified aorta. These results suggested that an eIF2α phosphorylation inhibitor could ameliorate VC pathogenesis by blocking eIF2α/ATF4 signaling, which may provide a new target for VC prevention and treatment.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
29110. Pharmacological potential of endothelin receptors agonists and antagonists
- Creator:
- Patočka, Jiří
- Type:
- model:article and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public