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1492. Treatment with cholecalciferol leads to increase of selected semen parameters in young infertile males: results of a 6-month interventional study
- Creator:
- Bartl, Igor, Ondrušová, Miroslava, Kužma, Martin, Jackuliak, Peter, Gažová, Andrea, Kyselovič, Ján, and Payer, Juraj
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- fyziologie člověka, lékařství, vitamin D, human physiology, medicine, Vitamin D receptor, Infertility, Male health, 14, and 612
- Language:
- English
- Description:
- High incidence of infertility along with low vitamin D levels was detected in otherwise healthy young men. The aim is to observe the effect of vitamin D supplementation on semen parameters as assessed by semen analysis in infertile men. In total, 45 men (mean age 36.6 years) in consecutive order were included, of whom 34 finished the study. Subjects were supplemented by vitamin D (cholecalciferol) 2500 IU/day. Vitamin D levels were assessed by HPLC. Semen analysis was performed strictly following 2010 WHO guidelines. Study periods were baseline and month 6. During follow-up, 20 %, 7.4 %, 22 % and 0.7 % increase in serum vitamin D levels, progressive sperm motility, sperm concentration and sperm morphology, respectively, were observed (all p<0.05). At follow-up end, 9 patients (26 %) reached normal sperm parameters of whom 2 fertilized their partner. There was no correlation between vitamin D and semen parameters observed. This study proves that vitamin D supplementation is possibly a modulator of sperm parameters in vitamin D deficient, otherwise healthy men. Although a direct relationship between vitamin D and sperm parameters was not observed obtaining adequate vitamin D levels could likely play a role in the male factor of infertility., Igor Bartl, Miroslava Ondrušová, Martin Kužma, Peter Jackuliak, Andrea Gažová, Ján Kyselovič, Juraj Payer., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1493. Treatment with coenzyme Q10, ω-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis
- Creator:
- Kucharská, Jarmila, Poništ, Silvester, Vančová, Oľga, Gvozdjáková, Anna, Uličná, Oľga, Slovák, Lukáš, Taghdisiesfejir, Mohsen, and Bauerová, Katarína
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- artritida, koenzym Q10, arthritis, coenzyme Q10, omega-3-polyunsaturated fatty acids, mitochondrial bioenergetics, skeletal muscle, 14, and 612
- Language:
- English
- Description:
- Rheumatoid arthritis (RA) and its animal model adjuvant arthritis (AA) are inflammatory diseases characterized by chronic inflammation, systemic oxidative stress and disturbed mitochondrial bioenergetics of skeletal muscle. The present study aimed to evaluate the effects of coenzyme Q10 - CoQ10 (100 mg/kg b.w.), omega-3-polyunsaturated fatty acids - ω-3-PUFA (400 mg/kg b.w.) and their combined treatment in AA on impaired skeletal muscle mitochondrial bioenergetics, inflammation and changes in levels CoQ9 and CoQ10 in plasma. Markers of inflammation (C-reactive protein, monocytechemotactic protein-1), antioxidant capacity of plasma, respiratory chain parameters of skeletal muscle mitochondria and concentrations of CoQ9 and CoQ10 in plasma and in muscle tissue were estimated. Treatment of the arthritic rats with CoQ10, ω-3-PUFA alone and in combination partially reduced markers of inflammation and increased antioxidant capacity of plasma, significantly increased concentrations of coenzyme Q in mitochondria and improved mitochondrial function in the skeletal muscle. Combined treatment has similar effect on the mitochondrial function as monotherapies; however, it has affected inflammation and antioxidant status more intensively than monotherapies. Long-term supplementary administration of coenzyme Q10 and ω-3-PUFA and especially their combination is able to restore the impaired mitochondrial bioenergetics and antioxidant status in AA., Jarmila Kucharská, Silvester Poništ, Oľga Vančová, Anna Gvozdjáková, Oľga Uličná, Lukáš Slovák, Mohsen Taghdisiesfejir, Katarína Bauerová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1494. TRH test in patients with diabetes mellitus type 1 and/or autoimmune thyroiditis. Changes in the pituitary-thyroid axis, reverse T3, prolactin and growth hormone levels
- Creator:
- Orlická, Eliška, Karel Vondra, Martin Hill, Jelena Skibová, Ivan Šterzl, and Václav Zamrazil
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, 14, and 612
- Language:
- English
- Description:
- E. Orlická, K. Vondra, M. Hill, J. Skibová, I. Šterzl, V. Zamrazil.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1495. TRH-like peptides
- Creator:
- Radovan Bílek, Marie Bičíková, and Libor Šafařík
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, peptidy, endokrinologie, peptids, endocrinology, TRH, TRH-like peptides, extrahypothalamic occurrence, biological function, 14, and 612
- Language:
- English
- Description:
- TRH-like peptides are characterized by substitution of basic amino acid histidine (related to authentic TRH) with neutral or acidic amino acid, like glutamic acid, phenylalanin e, glutamine, tyrosine, leucin, valin, aspartic acid and asparagine. The presence of extrahypothalamic TRH-like peptides was reported in peripheral tissues including gastroin testinal tract, placenta, neural tissues, male reproductive system and certain endocrine tissues. Work deals with the biological function of TRH-like peptides in different parts of organisms where various mechanisms may serve for realisation of biological function of TRH-like peptides as negative feedback to the pituitary exerted by the TRH-like peptides, the role of pEEPam such as fertilization-promoting peptide, the mechanism influencing the proliferative ability of prostatic tissues, the neuroprotective and antidepressant function of TRH-like peptides in brain and the regulation of thyroid status by TRH-like peptides., R. Bílek, M. Bičíková, L. Šafařík., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1496. Tumor necrosis factor α in various tissues of insulin-resistant obese koletsky rats: relations to insulin receptor characteristics
- Creator:
- Hřebíček, A., Rypka, M., Chmela, Z., Veselý, J., Magdaléna Kantorová, and Věroslav Golda
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, tumor necrosis factor α, insulin resistance, insulin receptor protein tyrosine kinase activity, 14, and 612
- Language:
- English
- Description:
- Tumor necrosis factor a (TNFa) was found to be significantly increased in skeletal muscles and retroperitoneal fat of obese insulin-resistant Koletsky rats as compared to control Wistar rats. This increase was accompanied by a depression of insulin receptor protein tyrosine kinase (PTK) activity. Neither the insulin-binding capacity nor insulin receptor affinity were related to this TNFa increase in these tissues. In the liver, no significant changes of TNFa content and only a lowering of insulin-binding capacity were found. It is concluded that an increased TNFa content in muscles and fat (but not in the liver) contributes to insulin resistance by lowering insulin receptor protein tyrosine kinase activity, while other insulin receptor characteristics (insulin-binding capacity and affinity of insulin receptors to the hormone) do not seem to be influenced by this factor., A. Hřebíček, M. Rypka, Z. Chmela, J. Veselý, M. Kantorová, V. Golda., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1497. Twenty-four hour blood pressure profile in subjects with different subtypes of primary aldosteronism
- Creator:
- Tomáš Zelinka and Jiří Widimský
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, krevní tlak, blood pressure, ambulatory blood pressure monitoring, primary aldosteronism, circadian blood pressure variability, 14, and 612
- Language:
- English
- Description:
- The aim of our study was to evaluate the potential differences in blood pressure (BP) profile in subjects with different forms of primary aldosteronism (PA). Simultaneously, we studied the effects of PA treatment on BP curve. We therefore monitored 24-hour ambulatory blood pressure values in 22 subjects with aldosterone-producing adenoma (APA), 22 subjects with idiopathic hyperaldosteronism (IHA) and 33 subjects with essential hypertension (EH) as controls. We found a significantly attenuated nighttime systolic BP decline in the APA group (P=0.02). Patients with IHA had lower nighttime systolic BP values (P=0.01) and also a diastolic BP decline (P=0.02) during the night in comparison with EH. We did not detect any significant differences in BP profile characteristics between APA and IHA. Specific treatment of primary aldosteronism (adrenalectomy, treatment with spironolactone) led to the normalization of the BP curve with a marked BP decline. Our study thus demonstrates a blunted diurnal BP variability in patients with primary aldosteronism the specific treatment of which normalized previously attenuated nocturnal BP fall., T. Zelinka, J. Widimský., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1498. Two-generation diet-induced obesity model producing mice with increased amount of body fat in early adulthood
- Creator:
- Kubandová, J., Dušan Fabián, Burkuš, J., Štefan Čikoš, Soňa Czikková, Mozeš, Š., Šefčíková, Z., and Juraj Koppel
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, obezita, obesity, diet-induced obesity, fat deposits, body weight, 14, and 612
- Language:
- English
- Description:
- The aim of our study was to develop a model producing obese mice in early adulthood (4-6 weeks) based on their over-nutrition during fetal and early postnatal development. The fertilized dams of the parental generation were fed the standard diet supplemented with high-energy nutritional product Ensure Plus during gestation and lactation. De livered weanlings were then fed with standard or supplemented diet and assessed for body fat deposits using EchoMRI at the ti me of early and late adulthood. Maternal over-feeding during th e period before weaning had the most significant effect on obesity development in the filial generation. In weanlings, signific antly higher body fat deposits and average body weight were recorded. Later, further significant increase in percentage of body fat in both male and female mice was observed. Withdrawal of the Ensure Plus supplement caused a decrease in the percentage of body fat in part of the filial generation. In offspring fed the standard diet, higher fat deposits persisted till the time of late adulthood. We conclude that this diet-induced obesity model might be used in exploration of the effects of elevated body fat on physiological functions of various organ systems during juvenile and early adulthood periods of life of a human being., J. Kubandová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1499. Two-phase response of rat pineal melatonin to lethal whole-body irradiation with gamma rays
- Creator:
- Kassayová, M., Eva Ahlersová, and Ivan Ahlers
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, ionizující záření, ionizing radiation, pineal melatonin, serotonin N-acetyltransferase activity, rats, 14, and 612
- Language:
- English
- Description:
- M. Kassayová, E. Ahlersová, I. Ahlers. and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
1500. Ultrastructural characteristics of aortic endothelial cells in borderline hypertensive rats exposed to chronic social stress
- Creator:
- Ľudmila Okruhlicová, Katarína Dlugošová, Mitašíková, M., and Iveta Bernátová
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Experimentální medicína, kardiovaskulární fyziologie, stres (psychologie), hypertenze, endotel, potkan, cardiovascular physiology, stress (psychology), hypertension, endothelium, Rattus norvegicus, social stress, ultrastructure, 14, and 616-092
- Language:
- English
- Description:
- Genetic predisposition and social stress may represent important risk factors in etiology of hypertension associated with endothelial dysfunction. Perturbations of endothelial structural integrity are also critical for the pathogenesis of vascular diseases. We examined effect of chronic social stress on structure of aortic endothelium in bord erline hypertensive (BHR) and normotensive Wistar rats. Male BHR – offspring of Wistar mothers and SHR fathers and age-matched W were exposed to 6-week crowding stress (5 rats/cage, 200 cm2/rat). Aortic tissue was processed for electron microscopy and NO synthase activity measurement. Crowding stress significantly increased blood pressure in BHR compared to basal values (140±3 mm Hg vs. 130±3 mm Hg, p<0.05) and reduced enzyme activity by 37 % (p<0.01) in the aorta of BHR. Local slight structural alterations of endothelium were found in non-stressed BHR (p<0.001) when compared with Wistar rats. Chronic stress caused marked (p<0.005) subcellular injury of endothelial cells in aorta of BHR characterized by mitochondrial damage, presence of vacuoles, increased number of lysosomes, Weibel-Palade bodies, changes of intercellular connections and local disruption of endothelium, while only slight changes were seen in Wistar rats. Results suggest increased sensitivity of aortic endothelium of BHR to chronic crowding that may contribute to acceleration of arterial dysfunction., Ľ. Okruhlicová, K. Dlugošová, M. Mitašíková, I. Bernátová., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public