Hypertrophied hearts are known for increased risk of arrhythmias and are linked with reduced ischemic tolerance. However, still little is known about state characterized only by increased left ventricle (LV) mass fraction. Seventeen isolated rabbit hearts with various LV mass were divided into two groups according to LV weight/heart weight ratio (LVW/HW ratio), namely group H and L (with higher and lower LVW/HW ratio, respectively) and underwent three short cycles of global ischemia and reperfusion. The differences in electrogram (heart rate, QRSmax, mean number, onset and dominant form of ventricular premature beats) and in biochemical markers of myocardial injury (creatine kinase, lactate dehydrogenase - LDH) and lipid peroxidation (4-hydroxy-2-nonenal - 4-HNE) were studied. As compared to group L, hearts in group H exhibited lower tolerance to ischemia expressed as higher incidence and severity of arrhythmias in the first ischemic period as well as increase of LDH and 4-HNE after the first reperfusion. In the third cycle of ischemia-reperfusion, the preconditioning effect was observed in both electrophysiological parameters and LDH release in group H. Our results showed consistent trends when comparing changes in electrograms and biochemical markers. Moreover, 4-HNE seems to be good potential parameter of moderate membrane alteration following ischemia-reperfusion injury., M. Hlaváčová, V. Olejníčková, M. Ronzhina, T. Stračina, O. Janoušek, M. Nováková, P. Babula, J. Kolářová, I. Provazník, H. Paulová., and Obsahuje bibliografii
The protective role of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well understood. In addition, integrity of the skeleton is positively influenced by certain trace elements (e.g. zinc, copper, manganese, magnesium, iron, selenium, boron and fluoride) and negatively by others (lead, cadmium, cobalt). Deficiency or excess of these elements influence bone mass and bone quality in adulthood as well as in childhood and adolescence. However, some protective elements may become toxic under certain condition s, depending on dosage (serum concentration), duration of treatment and interactions among individual elements. We review the beneficial and toxic effects of key elements on bone homeostasis., I. Zofkova, M. Davis, J. Blahos., and Obsahuje bibliografii
Článek se zabývá Levinasovou ideou „transcendence slov“. Sleduje úvahy tohoto autora o rozdílu mezi významem slov ve vztahu k Jinému a rolí slov v estetické události obrazu. Soustřeďuje se na Levinasovo zdůraznění kontrastu mezi tichem obrazu a zvukem dialogu., Dealing with Levinas’s idea of the “transcendence of words”, the article follows his treatment of the difference between the meaning of the words in relation to the Other and the role of the words in the aesthetic event of the image. The focus is on the way that Levinas emphasises the contrast between the silence of an image and the sound of a dialogue., and Miloš Ševčík.
Ve studii „Transcendence slov“ se Emmanual Levinas zabývá charakterem literárního obrazu. Porovnává ho s malbou a zdůrazňuje vizuální povahu obou těchto obrazů. Ticho těchto obrazů je však překonáno skandálem zaznívajících slov, která subjekt nabízí Jinému., In his study ‘The Transcendence of Words’, Emmanuel Levinas deals with the character of the literary image. He compares it with painting and emphasises the visual nature of both these images. However, the silence of both these images is overcome by the scandal of the resounding words which the subject offers to the Other., and Emmanuel Levinas.
Motto Strategie AV21 „Špičkový výzkum ve veřejném zájmu“ mj. předesílá podporu mezioborové a meziinstitucionální synergie více než 50 pracovišť Akademie věd. Právě proto, aby výzkum opravdu sloužil společnosti, otevřela Akademie věd nové Centrum transferu technologií, jehož prostory se hostům slavnostně představily 16. května 2016. and Marina Hužvárová.
The article deals with the typology of Baroque frontispieces in printed books published in Bohemian and Moravian printing houses in 1618-1765, which is viewed in terms of the function of the frontispieces in printing. The paper contains a detailed analysis of the main thematic variants of frontispieces. The thematic variants are analysed with respect to the content and genre of the work concerned with the aim to determine the main marketing strategies of Bohemian and Moravian printers, publishers or booksellers in the visual promotion of their products., Hana Beránková., Obsahuje anglický abstrakt a shrnutí., and Obsahuje bibliografii
My aim is to assess an argument against final causation being an irreducible metaphysical category. The argument in question is based upon the supposition that for anything to count as a cause, it must exist at the very moment of executing its causal action, which requirement can supposedly never be met by anything rightly pretending to be called a final cause. I argue that this argument is far from conclusive as there seem to be ways of blocking it - namely through adopting either a version of the eternalist ontology of temporal dimensions, or else a version of the possibilist ontology, each combined with either a version of the "Humean" approach to analysis of causal relations, or else with a version of the realist approach to causation., Jan Palkoska., and Obsahuje poznámky a bibliografii
Učená společnost České republiky ČR sdružující význačné vědce všech vědních oborů zasedala ve dnech 23. až 24. května 2016 v pražském Karolinu a sídle Akademie věd na Národní třídě. První den veřejné části jednání, jehož se zúčastnily význačné osobnosti badatelské i politické sféry, patřil tradičnímu ceremoniálu - předání medailí, cen a čestných uznání. Medaile Učené společnosti za zásluhy o rozvoj vědy převzali prof. Ivan Lefkovits a prof. František Vyskočil., Two eminent professorw were awarded the Medal of the Learned Society of the Czech Republic at the General Assembly of the Learned Society held on May 23-24, 2016. World-famous neurologist František Vyskočil and world-renowned immunologist Ivan Lefkovits were honored for their meritorious contributions to the advancement of sciences. Junior Scientist Awards were bestowed on Dr. Martin Ferus and Dr. Michal Malinský, awards were also granted to teachers and high school students., and Luděk Svoboda.