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1. Lack of an association between apolipoprotein B Xbal polymorphism and blood lipid parameters in childhood

Creator:
Hubáček, J. A., Pistulková, H., Píša, Z., Valenta, Z., Škodová, Z., and Poledne, R.
Type:
article, model:article, and TEXT
Subject:
apolipoprotein B, children, gene polymorphism, hypercholesterolaemia, and Xbal
Language:
English
Description:
The frequencies of the alleles of Xbal polymorphism in the apolipoprotein B gene were determined in two groups of children, 82 with high (HCG) and 86 with low (LCG) cholesterol levels. A slightly higher incidence of the X2X2 genotype in HCG was found, but the differences were not statistically significant. No relations were found between the Xbal polymorphic site and the levels of serum lipids and lipoproteins. Common Xbal polymorphism in the apolipoprotein B gene does not determine significantly the plasma cholesterol levels in childhood.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Neuromedin beta: P73T polymorphism in overweight and obese subjects

Creator:
Spálová, Jana., Hana Zamrazilová, Josef Včelák, Markéta Vaňková, Petra Lukášová, Martin Hill, Karolína Hlavatá, Petra Šrámková, Martin Fried, Bashar Aldhoon, Marie Kunešová, Běla Bendlová, and Vojtěch Hainer
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, endokrinologie, obezita, redukce tělesné hmotnosti, endocrinology, obesity, weight loss, neuromedin beta, gene polymorphism, eating behaviour, nutrient intake, 14, and 612
Language:
English
Description:
Neuromedin beta (NMB) is a member of the bombesin-like peptide family expressed in brain, gastroin testinal tract, pancreas, adrenals and adipose tissue. The aim of our study was to compare the frequency of P73T polymorphism in overweight and obese patients (37 men: age 50.6±11.7 years, BMI 41.1±7.8 kg/m2; 255 women: age 49.0±11.9 years, BMI 37.9±6.8 kg/m2) with that of healthy normal weight subjects (51 men: age 28.2±7.1 years, BMI 22.3±2.0 kg/m2; 104 women: age 29.1±9.1 years, BMI 21.5±1.9 kg/m2) and to investigate the polymorphism’s influence on anthropometric, nutritional and psychobehavioral parameters in overweight/obese patients both at the baseline examination and at a control visit carried out 2.5 years later, regardless of the patient́s compliance with the weight reduction program. No significant differences in the genotype distribution were demonstrated between normal weight and overweight/obese subjects. Male T allele non-carriers compared to T allele carriers had higher energy (p=0.009), protein (p=0.018) and fat (p=0.002) intakes and hunger score (p=0.015) at the beginning of treatment. Male T allele non-carriers had a more favorable response to weight management at the follow-up, as they exhibited a significant reduction in waist circumference, energy intake and depression score as well as a significant increase in dietary restraint. No significant differences between carriers and non-carriers were demonstrated in women at the baseline examination. Both female T allele carriers and non-carriers demonstrated similar significant changes in nutritional parameters and in restraint score at the follow-up. Nevertheless, only female non-carriers showed a significant decrease in the hunger score., J. Spálová, H. Zamrazilová, J. Včelák, M. Vaňková, P. Lukášová, M. Hill, K. Hlavatá, P. Šrámková, M. Fried, B. Aldhoon, M. Kunešová, B. Bendlová, V. Hainer., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Nos3 gene Rs1799983 and Rs2070744 polymorphisms in patients with periodontal disease

Creator:
Mazurek-Mochol, M., Kozak, M., Sawczuk, M., Maciejewska, A., D., Safranow, K., and Pawlik, A.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
gene polymorphism, NOS3 gene, and periodontal disease
Language:
English
Description:
Periodontal disease is a common oral disease. Inflammatory and immune responses to oral microorganisms initiate the development of periodontitis. Cigarette smoking is an important environmental risk factor for periodontitis. Another important inflammatory mediator is nitric oxide (NO). NO modulates vascular tone, microvascular permeability, leukocyte migration and oxidative activity, contributing to the direct killing of microorganisms. Several polymorphisms of the NOS3 gene have been detected, which may alter gene expression and NO synthesis. The aim of this study was to examine the association between the NOS3 rs1799983 and rs2070744 polymorphisms and periodontal disease. This study enrolled 200 patients with periodontal diseases (130 were non-smokers and 70 were smokers) and 160 control subjects (126 were non-smokers and 34 were smokers). Among the patients with periodontal disease, we observed a statistically increased frequency of patients with the CT genotype (TC vs. TT; 95%CI 1.83, OR 1.16–2.88, P = 0.011). There was a statisti-cally significant increased frequency of CT genotype carriers among non-smoking patients with periodontal disease as compared with non-smoking controls, whereas there were no statistically significant differences between smoking patients with periodontal disease and smoking control subjects. The results of our study suggest an association between the NOS3rs2070744 polymorphism and periodontal disease. and Corresponding author: Andrzej Pawlik
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

4. Office blood pressure, heart rate and A(-597)G interleukin-6 gene polymorphism in apparently healthy Czech middle-aged population

Creator:
Anna Vašků, Souček, M., Monika Pávková Goldbergová, and Jiří Vácha
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, krevní tlak, srdeční rytmus, kouření, blood pressure, heart rate, smoking, interleukin 6, gene polymorphism, healthy subjects, BMI, 14, and 612
Language:
English
Description:
The aim of the study was to assess the association between promoter polymorphism [A(-596)G] in interleukin-6 gene and office systolic and diastolic blood pressures, and the heart rate (HR) in apparently healthy Czech subjects. Furthermore, we evaluated the possible influence of gender, BMI and smoking on these supposed associations. An age-matched (40-50 years) and gender-matched (F/M=81/89) sample of apparently healthy Czech subjects (n=170, F/M=81/89) without hypertension, other cardiovascular diseases or diabetes was examined. The A(-596)G Il-6 gene polymorphism was detected by the PCR method. No differences in genotype distribution and/or allelic frequency was found between groups with lower systolic blood pressure (£ 122 mm Hg) and higher systolic blood pressure (> 122 mm Hg). Similarly, no differences in the IL-6 polymorphism were found between lower (£ 86 mm Hg) and higher (> 86 mm Hg) diastolic blood pressure groups. However, we proved a significant increase of genotypes AG+GG as well as the allele (-596)G in higher (>78 beats/min) heart rate group. The genotypes AG+GG represent significantly higher relative risk for higher HR frequency, especially in women. Among lean persons with a low heart rate frequency, fewer AG+GG genotypes were determined than among any other subjects. The genotypes AG+GG are more frequent in non-smoking persons with higher HR compared to non-smoking subjects with lower HR, especially in women. Gender, BMI and smoking substantially modify the distribution of A(-596)G Il-6 gene polymorphism in apparently healthy persons with lower or higher heart rate., A. Vašků, M. Souček, M. Goldbergová, J. Vácha., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

5. Strong association between APOA5 gene polymorphisms and hypertriglyceridaemic episodes

Creator:
Vrablik, M., Hubacek, J. A., Dlouha, D., Satny, M., Adamkova, V., and Ceska, R.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
triglycerides, apoa5, gene polymorphism, and prediction
Language:
English
Description:
Plasma triglyceride (TG) levels represent a significant risk factor of cardiovascular and total mortality. Concentrations of TG in the plasma depend, to a large extent, on the genetic background, and the apolipoprotein A5 (APOA5) gene seems to be one of the most powerful players in the plasma TG metabolism regulation. In total, we analysed three tagging APOA5 (rs964184, rs662799, rs3135506) SNPs in 209 patients with plasma TG levels over 10 mmol/l (HTG) on at least one occasion and in 379 treatment-naïve controls (NTG) with plasma TG values within the normal range. Minor alleles of all three analysed APOA5 polymorphisms significantly (all P < 0.0001) increased the risk of hypertriglyceridaemia. The most significant association (P < 0.0000001) was observed for the rs964184 polymorphism, where the minor GG homozygotes had the odds ratio (OR, 95% CI) for hypertriglyceridaemia development 21.30 (8.09-56.07, P < 0.000001) in com-arison with the major CC allele homozygotes. Carriers of at least one minor allele at rs3135506 had OR (95% CI) 4.19 (2.75-6.40); (P < 0.000005) for HTG development and similarly, carriers of a minor allele at rs662799 had OR (95% CI) 3.07 (2.00-4.72); (P < 0.0001). The cumulative presence of risk alleles (unweighted gene score) significantly differed between patients with episodes of high TG and controls at P < 0.0000001. There were 73 % of subjects without any of the risk alleles among the controls and 46 % in the patients. In contrast, the controls just included 3 % of subjects with score 3 and more in comparison with 18 % in HTG patients. We conclude that common APOA5 variants are very important genetic determinants of episodic hypertriglyceridaemia in the Czech population with a high potential to be applied in pe-sonalized medicine. and Corresponding author: Michal Vrablík
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public