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Start Over Subject plasma cholesterol

1. Effect of terguride on insulin binding, insulinaemia, glucose tolerance and hyperlipaemia in lean SHR Koletsky rats

Creator:
Golda, V. and Hilgertová, J.
Type:
article, model:article, and TEXT
Subject:
glucose tolerance, insulin binding, insulinaemia, fat pads, plasma cholesterol, plasma triglycerides, and terguride
Language:
English
Description:
Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plasma total cholesterol, plasma triglycerides, weight of fat pads, food consumption and body weight changes were studied in genetically hypertensive lean Koletsky rats. Long-term treatment with dopaminergic agonist terguride (0.2 mg/kg/day) normalized glucose tolerance and increased the percentage of bound insulin to erythrocytes in both sexes. Terguride decreased insulinaemia, cholesterolaemia, fat pads and body weight only in female rats. Food consumption was not influenced by terguride over the injection period.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Plasma triglycerides cosegregate with erythrocyte sodium content in F2 rats of HTG x lewis cross

Creator:
Zicha, J., Dobešová, Z., and Kuneš, J.
Type:
article, model:article, and TEXT
Subject:
hereditary hypertriglyceridaemic rats, genetic hypertension, plasma triglycerides, plasma cholesterol, erythrocyte Na+ content, Na+ leak, Na+-K+ cotransport, and Na+-K+ pump
Language:
English
Description:
The possible association of plasma lipids (triglycerides and cholesterol) with erythrocyte Na+ content (Na+j) and/or with alterations in red cell Na+ and K+ (Rb+) transport was studied in a population of F2 hybrids obtained by crossing hypertensive Prague hereditary hypertriglyceridaemic (HTG) rats with normotensive Lewis rats. The obtained data indicated a strong cosegregation (p<0.001) of plasma triglycerides with erythrocyte Na+ content. This was the cause for the close correlation of plasma triglycerides with the Ma+-K+ pump activity (measured as ouabain-sensitive Na+ extrusion). On the contrary, there was only marginal association (p<0.05) of erythrocyte Na+ content with plasma cholesterol which was significantly (p<0.01) related to bumetanide-sensitive Rb+ uptake mediated by the Ma+-K+ cotransport system. Na+ leak (bumetanide-resistant net Na+ uptake) correlated positively with blood pressure in female but not in male F2 rats. The close association between plasma triglycerides and erythrocyte Na+ content suggests that ion transport alterations might contribute to mechanisms responsible for the cosegregation of blood pressure with plasma triglycerides in HTG x Lewis F2 hybrids.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. The control of cholesterol metabolism and plasma lipid levels in infant rats

Creator:
Hahn, P. and Mahler, L.
Type:
article, model:article, and TEXT
Subject:
plasma cholesterol, plasma lipids, infant rats, plasma insulin, glucagon, and 3-hydroxy-3-glutaryl CoA reductase
Language:
English
Description:
Infant rats received an i. p. injection of insulin, anti-insulin serum, streptozotocin, antiglucagon serum or dexamethazone. All substances except the antiinsulin serum, raised the plasma triglyceride level. Both antisera decreased plasma cholesterol levels, while streptozotocin, insulin and dexametazone caused an increase. The activity of 3-hydroxy-3-glutaryl CoA reductase in liver and brown adipose tissue changed inversely to the cholesterol level. However, small intestinal enzyme activity was increased by insulin administration inspite of the rise in plasma cholesterol.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public