V kazuistike opisujeme prípad 49-ročného muža od detstva morbídne obézneho (BMI 40 kg/m2), s artériovou hypertenziou (asi od 15 rokov, liečená od roku 2004), dyslipidémiou (od roku 2006), diabetes mellitus 2. typu (od roku 2006, na inzulinoterapii od roku 2008) a fajčením (do roku 2011, 20 cigariet denne). Liečba: 16 druhov liekov, 8 na hypertenziu, statín, liečba diabetu, aspirín, alopurinol. V roku 2010 (ako 45-ročný) hospitalizovaný na našej klinike pre dyspnoe a bolesti na hrudníku s hodnotou krvného tlaku 180/110 mm Hg (zistené srdcové zlyhávanie s ejekčnou frakciou ĽK 33 %, vo funkčnej triede NYHA II, echokardiograficky: ľavá predsieň: 46 mm, rozmer ľavej komory v diastole: 70 mm, interventrikulárne septum: 12 mm, hypokinéza septa, dopplerovská ultrasonografia artérií dolných končatín (kalcifikácie, difúzne aterosklerotické zmeny, neprítomná stenóza), CT koronárna angiografia (signifikantná stenóza ľavej koronárnej artérie). Zahájená liečba perorálny furosemid 40 mg denne. V máji roku 2011 hospitalizovaný pre akútny koronárny syndróm: akútny NSTEMI spodnej steny (koronarografia: 2-cievne postihnutie, realizovaná PKI, implantovaný DES – ramus circumflexus, paroxyzmus fibrilácie predsiení, funkčná trieda NYHA III, ľavokomorová ejekčná frakcia: 30 %, pľúcna hypertenzia). V roku 2012 realizovaná renálna denervácia pre rezistentnú hypertenziu, implantovaný karotický stent pre stenózu karotickej artérie, prítomná diabetická nefropatia (KDOQI 3. stupňa, GF 40 ml/min). V auguste roku 2014 hospitalizovaný na našej klinike pre pľúcny edém, kardiogénny šok, akútnu ischémiu pravého predkolenia pri periférnej embolizácii, prítomný atriálny flutter, zhoršenie renálnych parametrov, echokardiograficky: ľavá predsieň: 55 mm, rozmer ľavej komory: 75 mm, akinéza septa a zadnej steny, oklúzia artérií pravej dolnej končatiny (vzhľadom na vážny stav pacienta kontraindikovaná angiochirurgická intervencia, zvažovaná amputácia končatiny z vitálnej indikácie), pacient zomrel po 4 dňoch hospitalizácie na intenzívnej jednotke po neúspešnej liečbe. Kombinácia ochorení diabetes, hypertenzia a ischemická choroba srdca je častá a prognosticky vážna. Diabetes zvyšuje kardiovaskulárnu morbiditu a mortalitu, a preto by sme mali hľadať diabetes u všetkých kardiovaskulárnych pacientov., The case study describes a case of 49-year-old man with morbid obesity since childhood (BMI 40 kg/m2), arterial hypertension (approx. since aged 15, treated since 2004), dyslipidemia (since 2006), type 2 diabetes mellitus (since 2006, on insulin therapy since 2008) and smoking (until 2011, 20 cigarettes a day). Treatment: 16 types of medication, 8 for hypertension, statin, therapy for diabetes, aspirin, allopurinol. In 2010 (when aged 45) hospitalized in our clinic with dyspnoea and chest pain with a high pressure reading of 180/110 mm Hg (identified symptoms of heart failure with LV ejection fraction of 33 %, in NYHA II functional class, echocardiographically: left atrium: 46 mm, left ventricular chamber size in diastole: 70 mm, interventricular septum: 12 mm, septal hypokinesis, Doppler ultrasonography of lower limb arteries (calcification, diffuse atherosclerotic changes, absent stenosis), CT coronary angiography (significant stenosis of the left coronary artery). Treatment started with 40 mg oral dose of furosemide daily. In May 2011 he was hospitalized with an acute coronary syndrome: acute NSTEMI of the inferior wall (coronarography: 2-vascular problems, implemented PKI, implanted DES – ramus circumflexus, paroxysmal atrial fibrillation, NYHA III functional class, left ventricular ejection fraction: 30 %, pulmonary hypertension). In 2012 renal denervation for resistant hypertension was carried out, carotid stent implanted for stenosis of the carotid artery, presence of diabetic nephropathy (KDOQI stage 3, GF 40 ml/min). In August 2014 admitted to our clinic with pulmonary oedema, cardiogenic shock, acute ischemia of the right calf with peripheral embolisation, presence of atrial flutter, impairment of renal parameters, echocardiographically: left atrium: 55 mm, left ventricle size: 75 mm, akinesis of the septum and posterior wall, occlusion of the right leg arteries (given the patient‘s serious state angio-surgical intervention was contraindicated, vitally indicated leg amputation considered), the patient died after 4 days of hospitalization in an intensive care unit after unsuccessful treatment. A combination of diabetes, hypertension and ischemic heart disease is frequent and prognostically serious. Diabetes increases cardiovascular morbidity and mortality and therefore we should check for diabetes in all cardiovascular patients., and Miroslav Pernický, Juraj Papinčák, Adriana Reptová, Soňa Kiňová, Ján Murín
In an open channel with a mobile bed, intense transport of bed load is associated with high-concentrated sediment-laden flow over a plane surface of the eroded bed due to high bed shear. Typically, the flow exhibits a layered internal structure in which virtually all sediment grains are transported through a collisional layer above the bed. Our investigation focuses on steady uniform turbulent open-channel flow with a developed collisional transport layer and combines modelling and experiment to relate integral quantities, as the discharge of solids, discharge of mixture, and flow depth with the longitudinal slope of the bed and the internal structure of the flow above the bed. A transport model is presented which considers flow with the internal structure described by linear vertical distributions of granular velocity and concentration across the collisional layer. The model employs constitutive relations based on the classical kinetic theory of granular flows selected by our previous experimental testing as appropriate for the flow and transport conditions under consideration. For given slope and depth of the flow, the model predicts the total discharge and the discharge of sediment. The model also predicts the layered structure of the flow, giving the thickness of the dense layer, collisional layer, and water layer. Model predictions are compared with results of intense bed-load experiment carried out for lightweight sediment in our laboratory tilting flume.
The paper deals with the paradoxes of inference and analysis. It attempts to show what is specific about these paradoxes. They have got a lot in common. Often, they are not considered paradoxes in the strict sense at all. Moreover, they both raise the same problem: How can the requirements of correctness and informativeness be both met for inference and for conceptual analysis? The strategies developed to address the problem are similar for both cases. In the paper, I claim that the paradoxes have common origins. This claim is supported by comparing different strategies adopted to resolve the problem. Regarding their origins, both paradoxes share the epistemological framework that is grounded in Aristotle’s theory of science. This is related to the problem of implicit knowledge, which is a variation on a dilemma formulated by Plato in his Meno. Aristotle’s solution to the dilemma of Meno is discussed and considered as another plausible strategy for dealing with the paradoxes of inference and analysis., Příspěvek se zabývá paradoxy odvození a analýzy. Snaží se ukázat, co je na těchto paradoxech specifické. Mají spoustu společného. Často nejsou vůbec považovány za paradoxy. Oba tyto otázky navíc vyvolávají stejný problém: Jak mohou být splněny požadavky na správnost a informativnost pro závěry a pro koncepční analýzu? Strategie vyvinuté pro řešení tohoto problému jsou podobné v obou případech. V příspěvku tvrdím, že paradoxy mají společný původ. Toto tvrzení je podpořeno porovnáním různých strategií přijatých k vyřešení problému. Pokud jde o jejich původ, oba paradoxy sdílejí epistemologický rámec, který je založen na Aristotelově teorii vědy. To souvisí s problémem implicitní znalosti, což je variace na dilema formulované Platónem v jehoMeno . Aristotelovo řešení dilematu Meno je diskutováno a považováno za další přijatelnou strategii pro řešení paradoxů odvození a analýzy., and Karel Šebela
The goal of this paper is to demonstrate that procedurally structured con- cepts are central to human communication in all cultures and throughout history. This thesis is supported by an analytical survey of three very different means of communication, namely Egyptian hieroglyphs, pictures, and Inca knot writing known as khipu. My thesis is that we learn, communicate and think by means of concepts; and regardless of the way in which the meaning of an expression is encoded, the meaning is a concept. Yet we do not define concepts within the classical set-theoretical framework. Instead, within the logical framework of Transparent Intensional Logic, we explicate concepts as logical procedures that can be assigned to expressions as their context-invariant meaning. In particular, complex meanings, which structurally match complex expressions, are complex procedures whose parts are sub-procedures. The moral suggested by the paper is this. Concepts are not flat sets; rather, they are algorithmically structured abstract procedures. Unlike sets, concepts have constituent sub-procedures that can be executed in order to arrive at the product of the procedure (if any). Not only particular parts matter, but also the way of combining these parts into one whole ''instruction'' that can be followed, understood, executed, learnt, etc., matters., Cílem příspěvku je ukázat, že procesně strukturované koncepty jsou ústředním bodem lidské komunikace ve všech kulturách a v průběhu dějin. Tato práce je podpořena analytickým průzkumem tří velmi odlišných komunikačních prostředků, konkrétně egyptských hieroglyfů, obrázků a psaní uzlů Inků známých jako khipu. Má diplomová práce je, že se učíme, komunikujeme a myslíme pomocí konceptů; a bez ohledu na způsob, jakým je význam výrazu zakódován, významem je pojem. Nedefinujeme však koncepty v rámci klasického teoretického rámce. Místo toho, v logickém rámci Transparentní Intenzionální Logiky, vysvětlujeme pojmy jako logické procedury, které mohou být přiřazeny výrazům jako jejich kontextově invariantní význam. Zejména složité významy, které strukturně odpovídají komplexním výrazům, jsou složité postupy, jejichž součástí jsou dílčí postupy. Morální návrh, který tento článek navrhl, je toto. Pojmy nejsou ploché soupravy; jsou to spíše algoritmicky strukturované abstraktní postupy. Na rozdíl od sad, koncepty mají dílčí dílčí postupy, které mohou být provedeny, aby se dospělo k produktu postupu (pokud existuje). Nezáleží jen na jednotlivých částech, ale také na způsobu spojování těchto částí do jedné ,,instrukce'', kterou lze sledovat, chápat, realizovat, učit se atd., Záleží na tom., and Marie Duží
Complete descriptions of the particle-size distribution (PSD) curve should provide more information about various soil properties as opposed to only the textural composition (sand, silt and clay (SSC) fractions). We evaluated the performance of 19 models describing PSD data of soils using a range of efficiency criteria. While different criteria produced different rankings of the models, six of the 19 models consistently performed the best. Mean errors of the six models were found to depend on the particle diameter, with larger error percentages occurring in the smaller size range. Neither SSC nor the geometric mean diameter and its standard deviation correlated significantly with the saturated hydraulic conductivity (Kfs); however, the parameters of several PSD models showed significant correlation with Kfs. Porosity, mean weight diameter of the aggregates, and bulk density also showed significant correlations with PSD model parameters. Results of this study are promising for developing more accurate pedotransfer functions.
The erosion, transport and deposition of sediments in small valley reservoirs represent a significant impact on their operations, mainly with regard to reducing the volume of their accumulation. The aim of this study is a comparison and uncertainty analysis of two modelling concepts for assessment of soil loss and sediment transport in a small agricultural catchment, with an emphasis on estimating the off-site effects of soil erosion resulted in sedimentation of a small water reservoir. The small water reservoir (polder) of Svacenicky Creek which was built in 2012, is a part of the flood protection measures in Turá Lúka and is located in the western part of Slovakia, close to the town of Myjava. The town of Myjava in recent years has been threatened by frequent floods, which have caused heavy material losses and significantly limited the quality of life of the local residents. To estimate the amount of soil loss and sediments transported from the basin, we applied two modelling concepts based on the USLE/SDR and WaTEM/SEDEM erosion models and validated the results with the actual bathymetry of the polder. The measurements were provided by a modern Autonomous Underwater Vehicle (AUV) hydrographic instrument. From the sediment data measured and the original geodetic survey of the terrain conducted at the time of the construction of the polder, we calculated changes in the storage volume of the polder during its four years of operation. The results show that in the given area, there has been a gradual clogging of the bottom of the polder caused by water erosion. We estimate that within the four years of the acceptance run, 10,494 m3 of bottom sediments on the Svacenicky Creek polder have accumulated. It therefore follows that repeated surveying of the sedimentation is very important for the management of the water reservoir.
Carbonate rocks host several large water and hydrocarbon reservoirs worldwide, some of them highly heterogeneous involving complex pore systems. Pre-salt reservoirs in the Santos Basin off the south-east coast of Brazil, are an example of such rocks, with much attention focused on proper characterization of their petrophysical and multiphase flow properties. Since it is very difficult to obtain rock samples (coquinas) from these very deep reservoirs, analogues from north-eastern Brazil are often used because of very similar geological age and petrophysical properties. We used a coquina plug from an outcrop in a quarry in northeast Brazil to perform a comprehensive set of analyses. They included Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDS), X-ray Diffraction (XRD), and micro-computed tomography (μCT) image acquisition using a series of pixel sizes, as well as direct permeability/ porosity measurements. Some of the experimental data were collected from the plug itself, and some from a small sample of the rock slab, including thin sections. Results included the carbonate rock composition and the pore system at different scales, thus allowing us to reconstruct and model the porosity and absolute permeability of the coquina using 3D digital imaging and numerical simulations with pore network models (PNMs). The experimental and numerical data provided critical information about the well-connected pore network of the coquina, thereby facilitating improved predictions of fluid flow through the sample, with as ultimate objective to improve hydrocarbon recovery procedures.
Sand-water slurry was investigated on an experimental pipe loop of inner diameter D = 100 mm with the horizontal, inclined, and vertical smooth pipe sections. A narrow particle size distribution silica sand of mean diameter 0.87 mm was used. The experimental investigation focused on the effects of pipe inclination, overall slurry concentration, and mean velocity on concentration distribution and deposition limit velocity. The measured concentration profiles showed different degrees of stratification for the positive and negative pipe inclinations. The degree of stratification depended on the pipe inclination and on overall slurry concentration and velocity. The ascending flow was less stratified than the corresponding descending flow, the difference increasing from horizontal flow up to an inclination angle of about +30°. The deposition limit velocity was sensitive to the pipe inclination, reaching higher values in the ascending than in the horizontal pipe. The maximum deposition limit value was reached for an inclination angle of about +25°, and the limit remained practically constant in value, about 1.25 times higher than that in the horizontal pipe. Conversely, in the descending pipe, the deposition limit decreased significantly with the negative slopes and tended to be zero for an inclination angle of about −30°, where no stationary bed was observed.