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82. Sorafenib, risk of bleeding and spontaneous rupture of hepatocellular carcinoma. A clinical case
- Creator:
- Rombolà, Ferdinando, Caravetta, Angelo, Mollo, Francesco, Spinoso, Antonio, Peluso, Lenino, and Guarino, Raffaele
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- staří, antitumorózní látky--škodlivé účinky, benzensulfonáty--škodlivé účinky, hepatocelulární karcinom--farmakoterapie--komplikace, krvácení--etiologie, lidé, nádory jater--farmakoterapie--komplikace, mužské pohlaví, pyridiny--škodlivé účinky, and spontánní ruptura--komplikace
- Language:
- English
- Description:
- Spontaneous rupture is a rare and dramatic complication of hepatocellular carcinoma (HCC), burdened by a high mortality. Here we describe a case of a 73-year-old man, who arrived at the ER because of syncope, and acute epigastric and right upper quadrant abdominal pain. He had a history of hepatitis C-related liver cirrhosis and HCC in treatment with sorafenib. The physical examination showed a state of hemorrhagic anemia with the presence of blood in the peritoneal cavity. The patient underwent an urgent liver resection. Thirty days after surgery, he was in good general condition. Sorafenib is a multikinase inhibitor recently introduced in the therapy of patients with advanced HCC. Among the various side effects reported in patients treated with sorafenib, there is a higher risk of bleeding. In conclusion, sorafenib may increase the risk of bleeding and rupture of HCC in susceptible individuals., Ferdinando Rombolà, Angelo Caravetta, Francesco Mollo, Antonio Spinoso, Lenino Peluso, Raffaele Guarino, and Literatura 15
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
83. Správné zavádění a používání prostředků POCT
- Creator:
- Schneiderka, Petr
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, směrnice pro lékařskou praxi, and TEXT
- Subject:
- vyšetření u lůžka--normy--organizace a řízení--využití, systémy podporující rozhodování v léčbě--normy--organizace a řízení--využití, lidé, řízení kvality, komplexní management jakosti, and testování odbornosti laboratoří--metody--normy
- Language:
- Czech
- Description:
- Schneiderka P. and Literatura 12
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
84. Standardy ošetřovatelské péče - kontrola procesu jejich naplňování
- Creator:
- Bocková, Soňa, Marečková, Jana, and Kozáková, Radka
- Format:
- 18-21, braille, text, and regular print
- Type:
- model:article, article, Text, and TEXT
- Subject:
- ošetřovatelská péče--normy, řízení kvality, průzkumy a dotazníky, statistika jako téma, interpretace statistických dat, zdravotní sestry, hodnocení postupů (zdravotní péče)--metody, odborné všeobecné sestry, akreditace, lidé, interní audit, registrované sestry, lower management, management první linie, kontrolní proces, and ošetřovatelský standardizovaný postup
- Language:
- Czech and English
- Description:
- Soňa Bocková, Jana Marečková, Radka Kozáková and Literatura 8
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
85. Stanovení 25-hydroxyvitaminu D v séru/plazmě – minireview
- Creator:
- Friedecký, Bedřich and Vávrová, Jaroslava
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, přehledy, and TEXT
- Subject:
- 25-hydroxyvitamin D 2--analýza--diagnostické užití, plazma--chemie, sérum--chemie, imunochemie--metody, referenční standardy, referenční hodnoty, biologický materiál - odběr a zpracování--normy, testování odbornosti laboratoří--využití, srovnatelnost metod, LC-MS/MS, and metrologické reference
- Language:
- Czech and English
- Description:
- Cíl: Minireview podává přehled aktuálního stavu měření 25-hydroxyvitaminu D v krevním séru. Metoda: Hodnocení analytické kvality měření 25-hydroxyvitaminu v programech externího hodnocení kvality. Výsledky separačních a imunochemických metod, stav metrologické reference a standardizace, předměty měření (analyty), preanalytická stabilita. Závěr: Je nutná standardizace měření jako podmínka vyšší úrovně srovnatelnosti mezi metodami a mezi laboratořemi využitím a rozvojem referenční metodiky a aplikací již existujících referenčních materiálů., Objective: A mini-review on the current state in serum 25-hydroxyvitamin D measurement. Methods: The review of used routine methods for the measurement the 25-hydroxyvitamin D in serum. The assessment of analytical quality by means of inter-laboratory comparison programs is presented. The current state of metrological reference and standardization is outlined. The methods, based on separation, with immunochemistry methods are compared. Problem of suitable analytes as subjects of measurement. Stability of analyte is described. Conclusion: There is the necessity of standardization for achieving the interlaboratory comparability and clinical utility by means of using reference material and reference method in routine practice., Friedecký B., Vávrová J., and Literatura 18
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
86. Stiff-person syndrome following tick-borne meningoencephalitis
- Creator:
- Ehler, Edvard, Latta, Ján, Mandysová, Petra, Havlasová, Jana, and Mrklovský, Milan
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- elektromyografie, klíšťová encefalitida--diagnóza--komplikace, lidé, magnetická rezonanční tomografie, mužské pohlaví, meningoencefalitida--komplikace, lidé středního věku, and syndrom celkového ztuhnutí--diagnóza--etiologie--farmakoterapie
- Language:
- English
- Description:
- Stiff-person syndrome (SPS) is a rare disorder characterized by muscle stiffness and painful spasms. Misdiagnosis may occur due to the fact that the clinical picture of SPS is often atypical. The main pathophysiologic mechanism underlying the development of SPS is insufficient inhibition at the cortical and spinal levels. There is good evidence for a primary autoimmune etiology. A 61-year-old man was admitted to a neurological department due to muscle hypertonia with episodic attacks of painful spasms predominantly affecting axial muscles. The symptoms developed shortly after tickborne meningoencephalitis. Electromyography (EMG) revealed signs of continuous motor unit activity. Antibodies against glutamate decarboxylase (anti-GAD) were highly elevated. We present a case of a man who developed clinically severe anti-GAD positive SPS, provoked by tick-borne encephalitis. After therapeutic plasma exchange (TPE) a rapid, temporary improvement of the clinical and neurophysiological findings was noted. Only after being placed on long-term immunosuppression did the patient achieve stable recovery. This case supports the importance of EMG findings and demonstrates the effect of TPE as well as the need for chronic immunosuppression in severe cases of SPS., Edvard Ehler, Jan Latta, Petra Mandysová, Jana Havlasová, Milan Mrklovský, and Literatura 22
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
87. The effect of wheat allergy on the course of atopic eczema in patients over 14 years of age
- Creator:
- Čelakovská, Jarmila, Ettlerová, Květuše, Ettler, Karel, Vaněčková, Jaroslava, and Bukač, Josef
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, and TEXT
- Subject:
- mladiství, dospělí, atopická dermatitida--etiologie--patologie, ženské pohlaví, lidé, imunoglobulin E--krev, mužské pohlaví, Patch Tests, Skin Tests, Wheat Hypersensitivity--co [Complications], and Wheat Hypersensitivity--di [Diagnosis]
- Language:
- English
- Description:
- Few studies concerning the importance of wheat allergy affecting the course of atopic eczema in adolescents and adult patients exist. Aim: The evaluation if wheat allergy can deteriorate the course of atopic eczema. Follow-up of patients with confirmed food allergy to wheat. Method: Altogether 179 persons suffering from atopic eczema were included in the study: 51 men and 128 women entered the study with an average age of 26.2 (s.d. 9.5 years) Dermatological and allergological examinations were performed, including skin prick tests, atopy patch tests, and specific serum IgE for wheat, open exposure test and double-blind, placebo-controlled food challenge test with wheat flour. Results: Wheat allergy affecting the coures of atopic eczema was confirmed in eight patients (4.5%) out of 179 patients enrolled in this study by double-blind, placebo controlled food challenge test. The course of atopic eczema showed a positive trend in patients with confirmed food allergy at 3, 6, 9, 12 month follow-up (statistical evaluation with paired t-test) after the elimination of wheat flour. Conclusion: Wheat allergy may play an important role in the worsening of atopic eczema (acting as a triggering exacerbating factor) only in a minority of adolescents and adult patients (4.5% in our study). The diagnostic methods (skin prick test, specific IgE, atopy patch test, history) cannot be used as separated tests for the determination of food allergy to wheat in patients with atopic eczema.Open exposure tests and double-blind, placebo-controlled food challenge should be used for the confirmation of wheat allergy affecting the course of atopic eczema., Jarmila Čelakovská, Květuše Ettlerová, Karel Ettler, Jaroslava Vaněčková, Josef Bukač, and Literatura 34
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
88. The role of hydrogen peroxide and other reactive oxygen species in wound healing
- Creator:
- Kanta, Jiří
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, přehledy, and TEXT
- Subject:
- hojení ran--fyziologie, granulační tkáň--cytologie--chemie, reaktivní formy kyslíku--farmakologie--metabolismus, hyperbarická oxygenace--využití, hypoxie--patofyziologie, peroxidy--farmakologie--terapeutické užití, lidé, and financování organizované
- Language:
- English
- Description:
- Wound healing is a complex physiological process important for tissue homeostasis. An acute injury initiates massive cell migration, proliferation and differentiation, synthesis of extracellular matrix components, scar formation and remodelling. Blood flow and tissue oxygenation are parts of the complex regulation of healing. Higher organisms utilize molecular oxygen as a terminal oxidant. This way of gaining energy for vital processes such as healing leads to the production of a number of oxygen compounds that may have a defensive or informatory role. They may be harmful when present in high concentrations. Both the lack and the excess of reactive oxygen species may influence healing negatively., Jiří Kanta, and Literatura 6
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
89. The use of rubber dam among Czech dental practitioners
- Creator:
- Kapitán, Martin and Šustová, Zdeňka
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, and TEXT
- Subject:
- sběr dat, vzorové postupy ve stomatologii--statistika a číselné údaje, ženské pohlaví, lidé, mužské pohlaví, and gumové blány--využití
- Language:
- English
- Description:
- Rubber dam is considered an ideal device for tooth isolation. Nevertheless, its usage is quite rare in the Czech Republic. The aim of this study was: firstly, to gather and evaluate information regarding the use of rubber dam by dentists in the Czech Republic and to compare it with other countries; secondly to find out whether there are any influencing factors as to rubber dam usage; and finally to find out frequency of rubber dam use separately in endodontic treatment and in placing fillings of different materials. A questionnaire-based survey was conducted. Dentists filled in the questionnaires during dental conventions, educational events, conferences and congresses. Rubber dam was routinely used by less than eight per cent of the respondents (n = 35); less than twenty-two per cent of the respondents (n = 97) used rubber dam occasionally, and more than seventy per cent of the respondents (n = 317) has never use it. The results showed that rubber dam is not used frequently in the Czech Republic. If rubber dam is used, then it is typically for endodontic treatment or composite fillings. There were several factors with a statistically significant influence on the usage of rubber dam, such as gender, length of professional career, percentage of direct payments, previous experience in using rubber dam, and undergraduate training in rubber dam use., Martin Kapitán, Zdeňka Šustová, and Literatura 22
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
90. Účinky dioxínov na ľudský organizmus
- Creator:
- Kováč, Ján and Kováč, Daniel
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, přehledy, and TEXT
- Subject:
- životní prostředí - znečištění--škodlivé účinky, polychlorované bifenyly--klasifikace--škodlivé účinky--toxicita, dioxiny--škodlivé účinky--toxicita, toxické účinky--metabolismus, biologické markery--analýza, receptory aromatických uhlovodíků - jaderný translokátor, kontaminace potravin--prevence a kontrola, kojení--škodlivé účinky, mateřské mléko--chemie, abnormality zubů--chemicky indukované, novorozenec, kojenec, lidé, krysy, and zvířata
- Language:
- Czech, Slovak, and English
- Description:
- Ján Kováč, Daniel Kováč and Literatura 58
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public