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942. Hormonální terapie pacientek s nádory prsu z pohledu gynekologa
- Creator:
- Bendová, Marie
- Type:
- model:article, article, Text, přehledy, and TEXT
- Subject:
- lidé, dospělí, lidé středního věku, staří, ženské pohlaví, nádory prsu--farmakoterapie, antitumorózní látky hormonální--farmakologie--škodlivé účinky--terapeutické užití, tamoxifen--škodlivé účinky--terapeutické užití, endometrium--patologie--účinky léků, nádory endometria--diagnóza--chemicky indukované--prevence a kontrola, biopsie, retrospektivní studie, gynekologická onemocnění--chemicky indukované--patologie, postmenopauza--účinky léků, klimaktérium--účinky léků, hormonální substituční terapie--kontraindikace--trendy, komplikace léčby tamoxifenem, patologie endometria, and hormonální substituční terapie
- Language:
- Czech and English
- Description:
- V práci zabývající se hormonální terapií pacientek s karcinomem prsu se nabízí přehled péče, která je těmto pacientkám poskytována gynekologem, od prevence a diagnostiky přes monitoraci hormonální terapie první linie. Jsou rozebrány příčiny stoupající incidence karcinomu prsu a historicky nastíněn rozvoj hormonální terapie pacientek. Hlavní část práce je věnována vlivu tamoxifenu na ženský organizmus, zejména na genitální trakt, a rozebrány jsou nežádoucí účinky v gynekologické oblasti, hlavně endometria. Uvedena je retrospektivní studie provedená na Gyn. por. klinice 3. LF UK zaměřená na detekci patologických nálezů endometria pod vlivem tamoxifenu. Je vypracován a uveden návrh algoritmu monitorace pacientek s Ca mammae s dělohou léčených tamoxifenem gynekologem a zmíněna jsou i úskalí této péče. Dalším problémem, který práce řeší, je kontroverzní možnost hormonální substituční terapie klimakterického syndromu u pacientek s karcinomem prsu., Author describes hormonal treatment of breast cancer pacients and review gynaecological care from prevention and diagnostics to monitoring of the first line hormonal treatment. Reasons of increasing breast cancer incidence are discussed and historical overview of hormonal treatment posibilities in pacients with breast cancer is summarized. The main part of the article characterizes influence of tamoxifen into woman organism, especially in her genital tract (endometrium changes) and side effects are analysed. The retrospective trial (Dept. Obst. and Gyn. 3-rd Medical Faculty) focusing pathological changes of endometrium under tamoxifen influence is mentioned. Design of monitoring algorithm of breast cancer patients with intact uterus under treatment of tamoxifen is elaborated. Complications and difficulties of this monitoring are specified. Another problem, controversial hormonal replacement therapy in breast cancer patients suffered from climacteric syndrom is solved., Marie Bendová, and Lit.: 15
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
943. Hospitalizace a úmrtí u seniorů v dlouhodobé ošetřovatelské péči související s preskripcí léčiv potenciálně nevhodných ve stáří
- Creator:
- Failová, Daniela
- Type:
- model:article, article, Text, and TEXT
- Subject:
- kvalita života, polypharmacy, farmakoterapie--škodlivé účinky, staří, prospektivní studie, lékové interakce, medikační omyly--statistika a číselné údaje, výzkum - podpora finanční - jako téma, and lidé
- Language:
- Czech
- Description:
- Daniela Failová
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
944. How the educational climate can influence the psychometric parameters of preschool children?
- Creator:
- Saliaj, Aurela, Kola, Ermira, Lazaj, Lorena, Rakipaj, Majlinda, and Çorraj, Emiljana
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- psychometrie, hygiena prostředí, školy mateřské, výchova dítěte, vývoj dítěte, společenská třída, statistika jako téma, psychomotorický výkon, výzkumný projekt, předškolní dítě, and lidé
- Language:
- English
- Description:
- Background: There are several environmental factors which influence the preschoolers psychomotor development and the most considerable ones are socioeconomic status and day cares learning&care environment. Aim of this study is to assess how the change of socioeconomic gradient and the quality of care environment influence the average and the differences in psychometric domains of ASQ3 in preschoolers. Method: We assessed the psychometric parameters of all preschoolers enrolled in some of day cares in Vlora city, Albania using the ASQ3. We also assessed the quality of care environment according to ECERSR and the socioeconomic status upon the fathers occupation. Results: In the end of this research we found that not only a considerable percentage of preschoolers included in this study have psychomotor delays, but also that these delays and the average of psychomotor development have a significant relationship with the environment factors, as socioeconomic status and care environment. Conclusions: Children development depends more on instructing capacities of kindergartens staff than mothers. So the public health workers should work more with mothers in this direction, focusing in the lowest socioeconomic classes., Aurela Saliaj, Ermira Kola, Lorena Lazaj, Majlinda Rakipaj, Emiljana Çorraj, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
945. HPV infekce u pacientek s cervikální intraepiteliální neoplazií
- Creator:
- Ševčík, L., Koliba, Peter, Gráf, P., and Konderla, M.
- Type:
- model:article, article, Text, and TEXT
- Subject:
- cervikální intraepiteliální neoplazie--ETIOLOGIE--VIROLOGIE, infekce papilomavirem--DIAGNÓZA, viry onkogenní, Papillomaviridae--GENETIKA, DNA sondy HPV, lidé, and ženské pohlaví
- Language:
- Czech
- Description:
- L. Ševčík, P. Koliba, P. Gráf
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
946. Human health resources in Kazakhstan
- Creator:
- Аkanov, Aikan, Меimanaliev, Тilek, Кyzayeva, Аizhan, Кumar, Ainur, and Kashafutdinova, Gulzhakhan
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- poskytování zdravotní péče, statistika jako téma, and lidé
- Language:
- English
- Description:
- We have analyzed human resources in healthcare of Kazakhstan over 19852011, and determined general trends and regularities. By the level of provision with physicians, Kazakhstan ranks as one of the leaders in the world, at the same time there have been a deficit of physicians in the Republic over the last 20 years, particularly in rural areas. As per its regions, there is an irregularity in the physicians provision rate: the most part of specialists is concentrated in cities Almaty and Astana, there is a deficit of physicians in the Almaty, Коstanai, NorthKazakhstan and Jambyl Oblasts. The effective use of human resources will enable to optimize expenditure for the public health and to improve the medical service quality., Aikan Аkanov, Тilek Меimanaliev, Аizhan Кyzayeva, Ainur Кumar, Gulzhakhan Kashafutdinova, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
947. Human papillomavirus genotype spectrum in studied group of montenegrin women
- Creator:
- Vujošević, Danijela, Vuksanović Vineta, Poljak, Mario, and Jokmanović, Nebojša
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, and TEXT
- Subject:
- lidé, ženské pohlaví, mladý dospělý, dospělí, infekce papilomavirem, Alphapapillomavirus--genetika--klasifikace, statistika jako téma, lidé středního věku, staří, lidský papilomavirus 16, and genotyp
- Language:
- English
- Description:
- The risk of high-grade lesions and carcinoma is known to correlate with specific high-risk HPV genotypes. The distribution of HPV types varies between countries and little is known about HPV distribution in our country. Therefore, the purpose of this study was to determine the range and frequency of HPV genotypes in studied group of women in Montenegro. HPV genotypes were determined using the method of enzyme restriction of PCR products amplified with group-specific primers MY09/MY11 and restricted with seven different restriction endonucleases. Out of the total number of women HPV infection was found in 1/5 of participants (20%). Genotyping performed in HPV DNA positive women shows that the HPV genotype 16 is dominant and present in more than 1/3 of the participants (36.8%). The second most frequent HPV infection is with HPV genotype 58 and it is found in 10.5% of participants. HPV 31 and HPV 6 infections are present in 7.9% of women, while infections with other genotypes were demonstrated individually by 2.6%. Multiple HPV infection was demonstrated in 18.4% and they are dominant in younger women (aged 25 to 30 years)., Danijela Vujošević, Vineta Vuksanović, Mario Poljak, Nebojša Jokmanović, and Literatura 21
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
948. Human plasma and human platelet-rich plasma as a substitute for fetal calf serum during long-term cultivation of mesenchymal dental pulp stem cells
- Creator:
- Suchánková Kleplová, Tereza, Soukup, Tomáš, Řeháček, Vít, and Suchánek, Jakub
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
- Subject:
- zvířata, skot, buněčné kultury--metody, proliferace buněk, buňky kultivované, kultivační média, zubní dřeň--cytologie, fetální krev, lidé, mezenchymální stromální buňky, plazma bohatá na destičky, and čas
- Language:
- English
- Description:
- AIMS: Our aims were to isolate and cultivate mesenchymal dental pulp stem cells (DPSC) in various media enriched with human blood components, and subsequently to investigate their basic biological properties. METHODS: DPSC were cultivated in five different media based on α MEM containing different concentrations of human plasma (HP), platelet-rich plasma (PRP), or fetal calf serum (FCS). The DPSC biological properties were examined periodically. RESULTS: We cultivated DPSC in the various cultivation media over 15 population doublings except for the medium supplemented with 10% HP. Our results showed that DPSC cultivated in medium supplemented with 10% PRP showed the shortest average population doubling time (DT) (28.6 ± 4.6 hours), in contrast to DPSC cultivated in 10% HP which indicated the longest DT (156.2 ± 17.8 hours); hence this part of the experiment had been cancelled in the 6th passage. DPSC cultivated in media with 2% FCS+ITS (DT 47.3 ± 10.4 hours), 2% PRP (DT 40.1 ± 5.7 hours) and 2% HP (DT 49.0 ± 15.2 hours) showed almost the same proliferative activity. DPSC's viability in the 9th passage was over 90% except for the DPSC cultivated in the 10% HP media. CONCLUSIONS: We proved that human blood components are suitable substitution for FCS in cultivation media for long-term DPSC cultivation. and T. Suchánková Kleplová, T. Soukup, V. Řeháček, J. Suchánek
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
949. Humánní biomonitoring a jeho vývoj z národního i mezinárodního hlediska
- Creator:
- Černá, Milena, Krsková, Andrea, Očadlíková, Danuše, Forysová, Kateřina, and Kubínová, Růžena
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, přehledy, práce podpořená grantem, and TEXT
- Subject:
- vystavení vlivu životního prostředí--statistika a číselné údaje--škodlivé účinky, životní prostředí - monitorování--metody, životní prostředí - znečištění--prevence a kontrola, látky znečišťující životní prostředí--analýza, biologické markery--analýza, and lidé
- Language:
- Czech and English
- Description:
- Milena Černá, Andrea Krsková, Dana Očadlíková, Kateřina Forysová, Růžena Kubínová
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
950. Humorální rejekce po transplantaci ledviny- editorial
- Creator:
- Zadražil, Josef
- Type:
- model:article, article, Text, and TEXT
- Subject:
- transplantace ledvin--metody--škodlivé účinky, rejekce štěpu--dějiny--etiologie--komplikace, tvorba protilátek--účinky léků, HLA-A antigeny--izolace a purifikace--škodlivé účinky, průtoková cytometrie--metody--využití, and lidé
- Language:
- Czech
- Description:
- Josef Zadražil and Lit. 20
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public