The Betic Cordillera, located at the westernmost end of the Mediterranean alpine belt, is deformed by overprinted folds and faults that produced the present-day relief since the Tortonian. In the frame of the COST 625 action, four sectors have been studied in the central part of the cordillera. In the Granad a Depression, the large NW-SE Padul normal fault deforms the SW periclinal end of the Sierra Nevada antiform. MT surveys in dicate the continuity in depth of high and low angle normal seismogenic faults and the presence of act ive detachment faults. In Tabernas regi on a good example of interaction between a N W-SE propagating normal fault, E-W strike-slip faults and the fold system is studied. In the Sierra Tejeda-Zafarraya and in the Balanegra-Sierra de Gádor areas, two new GPS networks ha ve been installed to determine the interaction and the development of large antiformal struct ures and normal faults with E-W and NW-SE orientations. However, taking into account the low tectonic activity of the studi ed region, a period of more than 5 year could be needed to determine with enough accuracy the development rate of the structures., Jesús Galindo-Zaldívar, Antonio Gil, Carlos Sanz de Galdeano, Stefan Shanov and Dumitru Stanica., and Obsahuje bibliografické odkazy
The paper presents the results of fieldwork and geodetic surveys carried out on a landslide in Wleń (Western Sudetes, Izerskie Foothills). This reactivated landslide occured firstly in 2011 and later on 16th July 2016, following heavy rainfall in the Lower Silesia region, and covered an area of ca. 1100 m2 above the renovated “Leśny Dwór” guesthouse in Wleń town. The main scarp of the landslide is built of strongly deformed Upper Permian (Zechstein) heterolithic deposits, composing the marginal part of the Wleń Graben - a NW-SE elongated, tectonic sub-unit within the North Sudetic Synclinorium. The landslide was a consequence of undercutting of steep slopes of the Bóbr River valley by anthropogenic activities and loading of the slope surface by blocks and pedestrian paths in the vicinity of the guesthouse. Monitoring of landslide activity was performed using the initial surface model of the slope subjected to mass movements, LiDAR elevation data, as well as 3D point cloud data from a non-metric camera on an Unmanned Aerial Vehicle (UAV). They were used to construct digital elevation models (DEMs) of the area covered by the landslide. The DEM from photogrammetric UAV data was processed using Structure from Motion (SfM) technology. The obtained dataset was verified by additional measurement series from terrestrial laser scanning (TLS). and Kowalski Aleksander, Wajs Jaroslaw, Kasza Damian.
The knowledge of the curing process of polysiloxane resin is an important factor for the optimal preparation of the precursor of ceramic materials/composites/. It was observed that different physical method explaining the cure process e.g. /IR, NMR/ and examined experimentally the method of dielectric analyses/DA/. It was found that the method DA with the addition of the dopant makes the monitored system to increase its conductivity for the certain type of polymer. This enables to influence the properties of the final composite during its curing with the help of the approprietly selected temperature and pressure depending on time., Petr Hron, Miloslav Burian, Šárka Hytychová, Adolf Inneman and Zbyněk Sucharda., and Obsahuje bibliografii
The study aimed to evaluate if the monitoring of advanced glycation end products (AGEs), advanced oxidation protein products (AOPP), lipoperoxides (LPO) and interleukin-6 (IL-6) in plasma could help to predict development of diabetic complications (DC). Clinical and biochemical parameters including AGEs, AOPP, LPO and IL-6 were investigated in patients with type 2 diabetes mellitus (DM2) with (+DC) and without (-DC) complications. AGEs were significantly higher in both diabetic groups compared to controls. AGEs were also significantly higher in group +DC compared to -DC. AGEs significantly correlated with HbA1c. We observed significantly higher AOPP in both diabetic groups in comparison with controls, but the difference between -DC and +DC was not significant. LPO significantly correlated with BMI. IL-6 were significantly increased in both diabetic groups compared to controls, but the difference between -DC and +DC was not significant. There was no significant correlation between IL-6 and clinical and biochemical parameters. These results do not exclude the association between IL-6 and onset of DC. We suggest that the measurement of not only HbA1c, but also AGEs may be useful to predict the risk of DC development in clinical practice. Furthermore, the measurement of IL-6 should be studied as adjunct to HbA1c monitoring., V. Jakuš, E. Šándorová, J. Kalninová, B. Krahulec., and Obsahuje bibliografii
The paper presents a computer module for GPS slant delay determination using data from COAMPS (Coupled Ocean/Atmosphere Mesoscale Prediction System) mesoscale non-hydrostatic model of the atmosphere which is run on IA64 Feniks computer cluster in the Department of Civil Engineering and Geodesy of the Military University of Technology. The slant delay is the result of integrating the ray (eikonal) equation for the spatial function of tropospheric refraction along the GPS wave propagation path. The work is a phase of research concerning operational methods of GPS slant delay determination using data from mesoscale non-hydrostatic models of the atmosphere, like COAMPS of the Naval Research Laboratory (NRL) and the Weather Research and Forecasting (WRF)., Mariusz Figurski, Marcin Gałuszkiewicz, Paweł Kamiński and Krzysztof Kroszczński., and Obsahuje bibliografické odkazy
Assuring the stability of underground headings in order to fulfill their technical functions without any disturbance and provide a safe workplace for mining staff seems to be a fundamental issue in mining activity. In recent years, rockbolts: bar or cable have been most frequently applied as a means of reinforcement. Such a construction is often referred to as a stand-and-roofbolting support. The paper presents sample results of monitoring stand-and-roof-bolting support systems selected from numerous research projects carried out by the authors. The results discussed below are based on the measurements of the strength parameters of rocks in the laboratory and in-situ research, convergence of underground excavations, forces in rockbolts, separation of roof rock strata tested with extensometric probes, telltales and endoscopes, as well as steel yielding support frames load tested with dynamometers. The complex measurements of stand-and-roof-bolting supports along with specifications of geological, mining and geomechanical conditions allowed to formulate a proper evaluation of support behavior and its effectiveness for particular conditions., Zbigniew Niedbalski, Piotr Małkowski and Tadeusz Majcherczyk., and Obsahuje bibliografii
Ground deformations (e.g., landslide and subsidence) have substantially risen recently around Penang Island, Malaysia. The development of hillslopes for rapid urbanisation and heavy rainfall has detrimental impacts on Penang Island soil layers. Modelling, simulation, and the development of susceptibility maps were past methods used to predict potential ground deformations of Penang Island. There is no published work on the Interferometry Synthetic Aperture Radar (InSAR) technique, where ground deformation of the region has been holistically studied. This work integrates the Persistent Scatterer InSAR (PS-InSAR) technique with Ground Penetrating Radar (GPR) to monitor the deformation on the island and identify possible subsurface causes for the disturbance. Twenty-four descending Sentinel-1A datasets acquired between 14th July 2017 and 13th October 2018 were processed to monitor and map ground deformation areas with a focus on three selected regions- Batu Feringghi (BF), Paya Terubong (PT), and Tanjung Bungah (TB), where multiple landslides occurred between 2017 and 2018. InSAR results were later analysed using the Statistical Package for the Social Sciences (SPSS) tool and validated by the available Global Positioning System (GPS) analysis. InSAR analyses reveal the mean deformation values of -3.13 mm/yr, -2.76 mm/yr and -4.77 mm/yr for the BF, PT, and TB areas. GPR surveys were conducted with a 300/800 MHz dual-frequency antenna at the three selected study areas. Anomalies (wall cracks, road fissures, cavities, drains, and pipes) detected using GPR profiles correlated well with the permanent scatterer points calculated using the InSAR technique., Kazeem Olukunle Rauff and Ismail Ahmad Abir., and Obsahuje bibliografii
The Rana Gruber iron oxide mining company in Norway has started to develop a new underground production level in order to continue operation in the Kvannevann mine. The planned change of mining system to sub-level caving (SLC) involves the removal of protective pillars below the former Kvannevann open-pit. Surface deformation on the hanging-wall and footwall sides of the deposit and caving of rock into the old pit is expected. When uncontrolled, this represents a threat to the underground mining operation below the open-pit. Trial removal of the protective pillar in the western part of the deposit has already caused fracturing of the rock mass on the hanging-wall side. Therefore, with the aim to monitor and control the rock mass deformation process in this area and ensure safe operation of the mine, a monitoring system based on periodic total station and GPS measurements in a three-tier control-measurement network has been developed and tested. In this paper the concept of this system, results of field work and recommendations for the system implementation is presented. The proposed concept has been used to implement a real system in the mine., Jan Blachowski, Steinar Ellefmo and Erik Ludvigsen., and Obsahuje bibliografii
Úvod: Léčba inzulinovou pumpou (IP) je jedním ze způsobů intenzivní terapie inzulinem, určeným preferenčně pro pacienty s diabetem 1. typu. Cena léčby je vyšší než léčba klasickým bazálbolusovým a inzulinovým režimem pomocí opakované aplikace inzulinu dávkovačem. Cíl: Zhodnocení kvality monitorování terapie IP u pacientů s DM v reprezentativním vzorku populace pacientů s DM v ČR vedených v databázi Všeobecné zdravotní pojišťovny České republiky (VZP), u níž bylo v roce 2014 pojištěno 63 % populace ČR. Metodika: V databázi VZP jsme identifikovali všechny osoby, které měly v letech 2009–2013 záznam o diagnóze DM (E10–E16 podle MKN 10), nebo měly předepsanou jakoukoliv antidiabetickou terapii (ATC skupina A10). Za celé období 2009–2014 bylo v datech VZP identifikováno celkem 4 002 unikátních pacientů s diabetem, kteří byli v hodnoceném období léčeni IP. Incidence pro rok 2014 (nově léčení inzulinovou pumpou): všichni pacienti, kteří měli v roce 2014 vykázanou IP a zároveň v předešlém období 2009–2013 není záznam o vykázání IP. Prevalence pro rok 2014 (všichni léčení inzulinovou pumpou): všichni pacienti, kteří v období 2010–2014 mají alespoň jednou vykázanou inzulinovou pumpu a zároveň nezemřeli před rokem 2014. Parametry kontroly kvality (vyšetření HbA1c a spotřeba diagnostických proužků pro testování hladiny glukózy) u pacientů léčených IP byly podrobně hodnoceny pouze pro rok 2014, a to u všech pacientů léčených inzulinovou pumpou v roce 2014 po celý rok (tj. od 1. 1. 2014 do 31. 12. 2014), tedy celkem u 3 189 pacientů. Výsledky: V roce 2014 bylo celkem 247 incidentních pacientů a celkem 3 794 prevalentních pacientů. Nově byla IP nasazena téměř v 50 % u pacientů ve věkovém rozmezí 20–39 let. V roce 2014 byla průměrná frekvence vyšetření HbA1c 3,38/pacienta a nejméně jednou byl vyšetřen u 98,5 % pacientů. Průměrná spotřeba diagnostických proužků pro testování hladiny glukózy na jednoho pacienta byla 879 kusů. Závěr: Pilotní projekt hodnocení parametrů kvality monitorování terapie IP ukazuje, že pacienti léčení IP mají poměrně často kontrolovaný glykovaný hemoglobin (3,38 vyšetření u jednoho pacienta v roce 2014) a průměrně si měří glykemii 2–3 krát denně. Klíčová slova: CSII – diabetes mellitus – monitorování kompenzace diabetu – inzulinová pumpa, Introduction: Insulin pump treatment (IP) is one of the ways of intensive insulin therapy, designed preferentially for patients with type 1 diabetes. The price of the treatment is higher than that of the conventional basalbolus and insulin regimens using repeated insulin application with a dose selector. Goal: Quality assessment of IP therapy monitoring in patients with DM in a representative sample of the patient population with DM kept in the database of the General Health Insurance Company of the Czech Republic (VZP) which provided health care coverage for 63% of Czech population in 2014. Methodology: We identified all individuals in the VZP database who had a record of DM diagnosis (E10 – E16 based on ICD 10) or who had any antidiabetic therapy prescribed (ATC group A10) in the period of 2009–2013. Over the whole period of 2009–2014 there were overall n = 4 002 unique patients with DM identified in the VZP data, who were treated with IP within the assessment period. Incidence for the year 2014 (the newly treated with an insulin pump): all patients who had IP recorded in 2014 while in the preceding period of 2009–2013 they had no record of IP use. Prevalence for the year 2014 (all treated with an insulin pump): all the patients who for the period of 2010–2014 had at least once insulin pump use recorded and who did not die before 2014. Quality control parameters (HbA1c examination and consumption of glucose level test strips) for patients treated with IP were only assessed in detail for the year 2014, namely for all patients undergoing insulin pump treatment in 2014 throughout the year (i.e. from 1 January 2014 to 31 December 2014), i.e. in n = 3 189 patients in all. Results: In 2014 there were 247 incident patients and 3 794 prevalent patients. IP was newly introduced for almost 50% of the patients aged 20–39 years. In 2014 an average frequency of HbA1c examination equaled 3.38 per patient and 98.5% patients were examined for HbA1c at least once. An average consumption of glucose level testing strips per patient was 879 pieces. Conclusion: The pilot project of assessment of quality parameters for IP therapy monitoring shows that the patients treated with IP have glycated hemoglobin checked quite frequently (3.38 checkups per patient in 2014) and they measure their blood glucose 2–3 times a day on average. Key words: diabetes mellitus – monitoring of diabetes compensation – insulin pump – CSII, and Zdeněk Rušavý, Petr Honěk, Ladislav Dušek, Tomáš Pavlík, Denisa Janíčková Žďarská, Milan Kvapil
Monoamine oxidase (MAO, type A and B) and semicarbazide-sensitive amine oxidase (SSAO) metabolize biogenic amines, however, the impact of these enzymes in arteries from patients with type 2 diabetes remains poorly understood. We investigated the kinetic parameters of the enzymes to establish putative correlations with noradrenaline (NA) content and patient age in human mesenteric arteries from type 2 diabetic patients. The kinetic parameters were evaluated by radiochemical assay and NA content by high-performance liquid chromatography (HPLC). The activity of MAO-A and SSAO in type 2 diabetic vascular tissues was significantly lower compared to the activity obtained in non-diabetic tissues. In the correlation between MAO-A (Km) and NA content, we found a positive correlation for both the diabetic and non-diabetic group, but no correlation was established for patient age. In both groups, MAO-B (Vmax) showed a negative correlation with age. The results show that MAO-A and SSAO activities and NA content of type 2 diabetic tissues are lower compared to the non-diabetic tissues, while MAO-B activity remained unchanged. These remarks suggest that MAO-A and SSAO may play an import ant role in vascular tissue as well as in the vascular pathophysiology of type 2 diabetes., S. F. Nunes ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy