Pacient s trombózou mozkových splavů a současným intracerebrálním hematomem parieto-okcipitálně byl neúspěšně léčen plnými dávkami intravenózní antikoagulace. Vzhledem k postupné progresi klinického stavu vedoucí ke ztrátě vědomí byla indikována endovaskulární intervence. Pro časté ucpávání aspiračního systému Penumbra byl originálně použit guiding katétr Neuron (současně se Separator 3D) zavedený přímo do trombu namísto Reperfusion katétru se současnou aspirací trombu. Tento postup byl bezpečný a úspěšný a může být použit u pacientů s rozsáhlým trombotickým postižením. Klíčová slova: trombóza mozkových splavů – trombektomie – endovaskulární – aspirační systém Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy. Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů., A patient with ongoing cerebral venous sinus thrombosis and a parieto-occipital intracerebral haematoma was unsuccessfully treated with full-dose intravenous anticoagulation. A common endovascular aspiration technique was indicated because of the progressive severe deterioration, the level of consciousness had failed. As a novel approach, we used the 6F Neuron guiding catheter (together with The Separator 3D) inserted directly into the thrombus instead of the Reperfusion Catheter, for mechanical disruption of the thrombus mass together with continual aspiration. This procedure was safe and successful and can be used in cases of frequent aspiration catheter occlusions by a large amount of thrombus fragments., and J. Vanicek, M. Bulik
Let $X$ be a Banach space. We give characterizations of when ${\cal F}(Y,X)$ is a $u$-ideal in ${\cal W}(Y,X)$ for every Banach space $Y$ in terms of nets of finite rank operators approximating weakly compact operators. Similar characterizations are given for the cases when ${\cal F}(X,Y)$ is a $u$-ideal in ${\cal W}(X,Y)$ for every Banach space $Y$, when ${\cal F}(Y,X)$ is a $u$-ideal in ${\cal W}(Y,X^{**})$ for every Banach space $Y$, and when ${\cal F}(Y,X)$ is a $u$-ideal in ${\cal K}(Y,X^{**})$ for every Banach space $Y$.
We determined if mature ladybirds use colour to initially find suitable host plants. We also determined whether ladybird beetles are capable of associating characteristics such as colour with the presence of prey. Here, we show that the multicoloured Asian ladybird beetle, Harmonia axyridis, has a differential response to yellow compared to green colours. Naive ladybirds, of both sexes, make significantly more visits and spend more time on yellow vs. green coloured pillars. After pairing yellow and green colours with the presence or absence of aphid prey, ladybirds alter their foraging behaviour. Beetles conditioned to having food on both pillar colours exhibited the same responses as naive beetles, while beetles conditioned to only yellow or green pillars did not exhibit a preference for visiting or spending time on different colours. However, there was a trend towards females spending more time on pillar colours on which they received reinforcement, and males spending more time foraging on colours opposite to that which they were reinforced. Thus, H. axyridis is capable of responding to cues such as colour, and its foraging behaviour can be altered as a result of prior experience.
Odpřahující protein 2 (UCP2, uncoupling protein 2) objevený v roce 1997 je homologem rozpřahujícího proteinu 1 (UCP1), který byl objeven v mitochondriích hnědé tukové tkáně novorozených savců a dospělých hibernantů jako součást mechanismu netřesové termogeneze. Zatímco UCP1 byl prokázán pouze v hnědé tukové tkáni, UCP2 je exprimován v kosterním svalu, bílé tukové tkáni, plicích a v dalších buněčných populacích. Odpřahující proteiny fungují jako iontové kanály. Jejich otevření snižuje mitochondriální membránový potenciál, tím se snižuje účinnost energetické přeměny – snižuje se tvorba ATP a zvyšuje se uvolnění energie ve formě tepla. UCP proteiny tím, že odpřahují procesy oxidace od tvorby ATP, zvyšují oxidaci substrátů, snižují podíl redukovaných komponent respiračního řetězce a tím redukují produkci reaktivních kyslíkových radikálů mitochondriemi. V tomto článku jsou popsány možné funkce UCP2., Uncoupling protein 2 (UCP2), discovered in 1997, is the fi rst homologue of uncoupling protein 1 (UCP1) that was discovered in mitochondria of brown adipose tissue of newborn mammals and adult hibernators as the part of mechanism in non-shivering thermogenesis. While UCP1 was presented only in brown adipose tissue, UCP2 is expressed in skeletal muscle, white adipose tissue, lungs and in other cell populations. Uncoupling proteins work as ion channels. Opening of these channels decrease the mitochondrial membrane potential thereby the effi ciency of energy conversion is decreased – it is decreased production of ATP and is increased dissipation of energy in the form of heat. Uncoupling proteins uncouple the process of oxidation from the ATP formation, increase the substrate oxidation and decrease the part of reduced components of respiratory chain thereby reducing the production of reactive oxygen species in mitochondria. In this review possible functions of UCP2 are also described., Bolehovská R., Červinková Z., Pospíšilová M., Lotková H., Plíšková L., Palička V., and Lit.: 24
Novikov algebras were introduced in connection with the Poisson brackets of hydrodynamic type and the Hamiltonian operators in formal variational calculus. In this note we prove that the underlying Lie algebras of quadratic Novikov algebras are 2-step nilpotent. Moreover, we give the classification up to dimension $10$.
The paper will address the development of housing regimes in the new EU member states,introducing the analytical framework of a housing sector matrix to classifyforms of housing by tenure andintegration mechanism. Thus, ourhousing sector matrixcombines two common approaches: thestructure of housing provision (Ball and Harloe 1992) and the tenure-focused approach (Kemeny 1981, 1995). Starting from this rough typology of housing provisions, we also take further factors that have a major impact on the behaviour of stakeholders/actors into consideration, namely the legal/regulatory environment and the subsidy/tax system, to define the housing regimes. In its analysing of the development of the new member states the paperdifferentiates between global factors (economic development model, countries’ position in global economic structures, etc.) and local factors like the political/power structure, mainstream social ideology, the interplay betweendifferent stakeholders, etc. Institutional analyses (Bengtsson and Ruonavaara 2010) that take path-dependent factors into account are thus best able to address the process by which new housing regimes emerged in post-socialist countries and the degree to which we find convergence/divergence trends. The paper analyses three junctures in the development process after 1990: radical changes after the collapse of the old system; the development of the mortgage market and the regulation of the social sector at the turn of 2000; and reactions to the financial crisis of 2008. The paper concludes that the new member states are following the same trajectory despite their institutional differences.
Intraspecific variation in genome size makes it possible to study ongoing processes of genome size evolution. Although there are over 200 papers on intraspecific variation in genome size, there is still limited understanding of this phenomenon, especially as many of these papers are based on weak methodology and therefore report biased or false evidence of the extent of intraspecific variation. In this paper the recent progress in understanding the spatio-temporal dynamics of intraspecific variation in genome size caused by the gradual accumulation of mutations is reviewed. The results of the case studies on Microseris douglasii, Zea mays, Silene latifolia, Hordeum spontaneum and Lolium hybrids, and in particular that on Festuca pallens, are discussed. The variation in genome size that occurs within species is caused mainly by differences in the content of repetitive DNA, in particular it is a consequence of the dynamics of transposable elements. Variation may be induced and maintained polytopically.We assume that it is probably more frequent in groups of young radiating species. Even in the initial stages, the variation in genome size generated within a population seems to be restricted by selection, which is also important in stabilizing genome size within species. The long-term persistence of the variation within a population and its further accumulation may be enhanced by gametes with different genome sizes, produced by the segregation of unequally sized homeologous chromosomes. Over large geographical scales and across contrasting environmental gradients, the distribution of genome sizes within species may be influenced by the nucleotype effect, with smaller genomes being more successful at higher latitudes and altitudes and under stressful conditions. However, the small differences in genome size within species seem generally to be of minor importance relative to other components of plant fitness that may be selectively favourable under particular environmental or habitat conditions. The processes generating variation in genome size may be associated with phenotypic variation. While the shift in the genome size of a population through selection enables adaptive evolution of genome size in a newly arising species, the spatio-temporal variation in genome size within an ancestral species allows for a rapid multiple genome size divergence of related species through random drift in genome size (founder effect, bottleneck effect) during range fragmentation, hybridization and/or polyploidization.
In this article we show that significant differences between the foreign currency mortgage agreements in Hungary and Poland led to significant differences in monthly mortgage payments after the Global Financial Crisis (GFC) erupted. Hungarian banks were able to add a variable markup to the LIBOR3M that was connected to bank risk on top of the usual fixed markup. We compare the monthly mortgage payments and LTV levels of people who took out a CHF mortgage with those who obtained a local currency mortgage during the mortgage boom years of 2006–2008. We find that in the initial years of the mortgage CHF mortgages were cheaper than local currency mortgages, which allowed more people to buy housing. However, the GFC led to a deterioration of the exchange rate, and monthly payments and LTV levels (consequently?) increased. We analyse the mortgage costs and LTV levels of the 2006-2008 foreign currency (FX) mortgage vintages in Hungary and Poland between 2006 and 2020 and compare them to local currency mortgages. We also simulate the effects of changing housing prices and wages on mortgages in the cities of Budapest and Warsaw.