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5912. The instant results of preoperative hepatic artery chemoembolization in hepatocellular carcinoma developed on the background of cirrhosis

Creator:
Juraev, M. D., Nematov O. N., and Yusupbekov, A. A.
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
předoperační péče, hepatocelulární karcinom--terapie, jaterní cirhóza--terapie, chemoembolizace terapeutická, výsledek terapie, staging nádorů, and lidé
Language:
English
Description:
Importance: Treatment of hepatocellular carcinoma remains a topical issue of Clinical Oncology. More than 80% of cases hepatocellular carcinoma develops in the presence of liver cirrhosis. These patients are doomed, many clinics they held only symptomatic treatment and life expectancy of patients is not more than 6 months. The main reason for the refusal of surgeons and Chemotherapeutists of treatment is associated cirrhosis. Purpose: To improve results of surgical treatment of liver cancer developed on cirrhosis Materials and methods: We analyzed the immediate results of treatment of 12 patients with hepatocellular carcinoma developed on a background of liver cirrhosis. From the large size of the tumor and associated liver cirrhosis, these patients the first stage of oil produced by hepatic artery chemoembolization of the affected lobe of the liver tumor. After 2 3 weeks performed liver resection. Results: After analyzing the results, we concluded: chemoembolization reduces tumor volume and weight, increases the physiological regeneration of hepatocytes unaffected tumor fraction, improves functional performance of the liver and does not affect the frequency and severity of postoperative complications., Juraev M.D., Nematov O.N., Yusupbekov A.A., and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5914. The Libechov minipig as a large animal model for preclinical research in Huntington’s disease – thoughts and perspectives

Creator:
Schramke, S., Schubert, R., Frank, F., Wirsig, M., Fels, M., Kemper, N., Schuldenzucker, V., and Reilmann, R.
Format:
print, text, and regular print
Type:
model:article, article, Text, práce podpořená grantem, and TEXT
Subject:
zvířata, zvířata geneticky modifikovaná, prasata, prasata miniaturní, modely u zvířat, preklinické hodnocení léčiv, Huntingtonova nemoc, chov, bydlení zvířat, časové faktory, mozek--anatomie a histologie, velikost orgánu, experimenty na zvířatech, etika výzkumu, and sekvenční homologie
Language:
Czech and English
Description:
Large animal models to explore the safety and tolerability of novel therapeutic approaches for Huntington’s disease (HD) are in exploration to achieve higher translational reliability in future studies. Recently, a Libechov minipig has been established as one new transgenic (Tg) large animal model for HD. We here discuss the advantages and limitations in using this model in HD with regards to breeding, housing, handling, and with respect to homology to humans and ethical considerations. A group of TgHD and wild type (WT) female minipigs (n = 36) was used to gain first evidence about abovementioned aspects. It is concluded that Libechov minipigs may fulfill an important role to bridge the gap between rodents and non‑human primates in the translation to humans. and S. Schramke, R. Schubert, F. Frank, M. Wirsig, M. Fels, N. Kemper, V. Schuldenzucker, R. Reilmann
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5915. The main approaches to the development of innovative pharmaceutical industry of the Russian Federation in the context of globalization

Creator:
Klunko, Natalia and Marynia, Reta
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
farmaceutický průmysl--ekonomika--statistika a číselné údaje--trendy and lidé
Language:
English
Description:
Pharmaceutical industry - one of the few areas in which innovations affect all of us, because ultimately have a direct impact on the duration and quality of life for us and our loved ones. In the presence of a strong market and a lack of understanding of the need for innovation is necessary, in our opinion, investing in basic research and facilitate the process of innovation in the pharmaceutical industry by the state and society. For the targeted development of pharmaceutical industry seems appropriate to determine at the state level prospects for the domestic pharmaceutical industry and its role in the international market, and develop a drug "doctrine" of Russia. This paper analyzed the problems of the state associated with the pharmaceutical market in the globalization period. Also investigated the theoretical aspects of the modern study of globalization in the light of the analysis for the global pharmaceutical industry and analyzes the major political and economic factors that have the most significant impact on the production of pharmaceuticals., Natalia Klunko, Reta Marynia, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5916. The management of Charcot midfoot deformities in diabetic patients

Creator:
Šponer, Pavel, Kučera, Tomáš, and Šrot, Jaromír
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, práce podpořená grantem, přehledy, and TEXT
Subject:
neuropatická artropatie--komplikace--terapie, diabetická noha--komplikace--terapie, and lidé
Language:
English
Description:
Charcot foot neuropathic osteoarthropathy is a disorder affecting the soft tissues, joints, and bones of the foot and ankle. The disease is triggered in a susceptible individual through a process of uncontrolled inflammation leading to osteolysis, progressive fractures and articular malpositioning due to joint subluxations and dislocations. The progression of the chronic deformity with a collapsed plantar arch leads to plantar ulcerations because of increased pressure on the plantar osseous prominences and decreased plantar sensation. Subsequent deep soft tissue infection and osteomyelitis may result in amputation. The Charcot foot in diabetes represents an important diagnostic and therapeutic challenge in clinical practice. Conservative treatment remains the standard of the care for most patients with neuropathic disorder. Offloading the foot and immobilization based on individual merit are essential and are the most important recommendations in the active acute stage of the Charcot foot. Surgical realignment with stabilization is recommended in severe progressive neuropathic deformities consisting of a collapsed plantar arch with a rocker-bottom foot deformity. and P. Sponer, T. Kucera, J. Brtková, J. Srot
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5917. The morphological peculiarities of the cerebrum arteries under the hemorrhagic and ischemic stroke in the patients with the metabolic syndrome

Creator:
Chuiko, Natalia
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, srovnávací studie, and TEXT
Subject:
metabolický syndrom--komplikace--patologie, cévní mozková příhoda--patologie, diabetické angiopatie--patologie, arteriae cerebrales--patologie, histologické techniky, ischemie mozku--patologie, cerebrální krvácení--patologie, endotel cévní--patologie, ateroskleróza--patologie, dospělí, lidé, and lidé středního věku
Language:
English
Description:
In this article, the results of the morphological study of the cerebral arteries in the patients with the hemorrhagic ischemic stroke on the background of metabolic syndrome were submitted. We established that under hemorrhagic stroke on the background of metabolic syndrome one could observe the atherosclerotic damages in the form of plaques, hyalinosis of vessels walls, destructive and necrotic changes of the middle coat of vessel wall, which are, in our opinion, the main reason in morphogenesis of hemorrhagic stroke. The atherosclerotic affection of the cerebral vessels with the lipidosis and fibrotic plaques in the vessel wall, which caused in disorganization of the vessel wall in the form intimae proliferation, structural reconstruction of the internal elastic membrane which resulted in narrowing of the vessel lumen and development of ischemia is the morphological basis for the ischemic stroke with the metabolic syndrome. Also diabetic microangiopathy with the development of the hyalinosis, vessels walls sclerosis, which provoked the microcirculatory and metabolism processes injury in the cerebral substance that complicate the disease course is the important factor of cerebral blood circulation damage., Natalia Chuiko, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5918. The number of immunoregulatory T cells (Treg) is increased in patients with psoriasis after Goeckerman therapy

Creator:
Kondělková, Kateřina, Vokurková, Doris, Krejsek, Jan, Borská, Lenka, Fiala, Zdeněk, Hamáková, Květoslava, and Andrýs, Ctirad
Format:
braille, text, and regular print
Type:
model:article, article, Text, práce podpořená grantem, and TEXT
Subject:
dospělí, dehet uhelný--terapeutické užití, dermatologické látky--terapeutické užití, ženské pohlaví, lidé, počet lymfocytů, mužské pohlaví, lidé středního věku, psoriáza--imunologie--terapie, T-lymfocyty regulační--imunologie, and terapie ultrafialovými paprsky
Language:
English
Description:
Regulatory T cells (Treg) are a specialized subpopulation of T cells that act to suppress inadequate immune response. Psoriasis is recognized as a T -cell driven immune-mediated systemic inflammatory disease with skin manifestation. Effective therapeutical approach to treat psoriasis is Goeckerman therapy (GT ). The aim of this study was to compare the number of Treg in the peripheral blood of 27 psoriatic patients and 19 controls and to evaluate the influence of GT on Treg population in peripheral blood of patients with psoriasis. There was no significant difference in the relative number of Treg cells in the peripheral blood of healthy blood donors and patients with psoriasis before initiation of GT (P = 0.2668). In contrary, the relative number of Treg cells in peripheral blood of patients with psoriasis after GT was significantly higher than those found in healthy blood donors (P = 0.0019). Moreover, the relative number of Treg is significantly increased in psoriatic patients after Goeckerman therapy compared to the pre-treatment level (P = 0.0042). In conclusion, this significant increase in Treg count after GT is probably associated with amelioration of inflammation by GT , as disease activity expressed as PASI decreased in our patients by GT (P = 0.0001)., Kateřina Kondělková, Doris Vokurková, Jan Krejsek, Lenka Borská, Zdeněk Fiala, Květa Hamáková, Ctirad Andrýs, and Literatura 39
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5919. The occurrence of fetal microchimeric cells in endometrial tissues is very common phenomenon in benign uterine disorders and the lower prevalence of fetal microchimerism is associated with better uterine cancer prognoses

Creator:
Hromadníková, Ilona, Kotlabová, Kateřina, Pirkova, Petra, Líbalová, Pavla, Vernerová, Zdenka, Svoboda, Bohuslav, and Kučera, Eduard
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, abstrakt z konference, and TEXT
Language:
Czech and English
Description:
Aims: This is the first study carried out to describe the role of fetal microchimerism (FM) in the pathogenesis of uterine cancer. The prevalence and concentration of male fetal microchimeric cells (FMCs) were examined in endometrial tissues in relation to subtypes of uterine cancer, and the histological grade and stage of the tumor. FM occurrence was analyzed in relation to risk factors including hypertension, obesity, type 2 diabetes, dyslipidemia, age at cancer diagnosis and patient pregnancy history. The prevalence and concentration of FMCs were examined in endometrial tissues using real-time polymerase chain reaction, SRY and b-globin sequences as markers for male fetal FMCs and total DNA. The studied group involved 47 type 1 endometrial cancers, 28 type 2 endometrial cancers and 41 benign uterine diseases. Results: While the prevalence of FM was decreased only in type 1 endometrial cancer, compared to benign uterine disorders (38.3% vs.70.7%; OR = 0.257, 95% CI: 0.105 to 0.628, p = 0.003), FMC concentrations did not differ within examined groups. The lower FM prevalence was detected in low grade (grade 1 and grade 2) endometrioid cancer (38.3% vs. 70.7%, OR = 0.256, 95% CI: 0.105 to 0.627, p = 0.003) and in FIGO 1 tumors (40.7% vs. 70.7%, OR= 0.285, 95% CI: 0.120 to 0.675, p = 0.004). No correlation between FM prevalence or FMC concentrations and risk factors was demonstrated. Conclusions: A lower prevalence of male FM seemed to be associated with better prognoses in uterine cancer based on tumor subtype, histological grade and stage of the tumor. and Ilona Hromadnikova, Katerina Kotlabova, Petra Pirkova, Pavla Libalova, Zdenka Vernerova, Bohuslav Svoboda, Eduard Kucera
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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